78 research outputs found

    Incidence of Obesity Among Mentally Retarded Children

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    An international survey of professionals in the field of mental retardation was conducted to determine significant research priorities in the education of students with mild retardation. A total of 67 individuals responded to survey which represented 83.7% of those contacted. Among the issues rated most highly were two clusters: vocational, career education and post-school adjustment and long term effects and generalization of effects of programs. Implications of the survey data are discussed and recommendations are provided

    Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival.

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    Cardiac stem cells and early committed cells (CSCs-ECCs) express c-Met and insulin-like growth factor-1 (IGF-1) receptors and synthesize and secrete the corresponding ligands, hepatocyte growth factor (HGF) and IGF-1. HGF mobilizes CSCs-ECCs and IGF-1 promotes their survival and proliferation. Therefore, HGF and IGF-1 were injected in the hearts of infarcted mice to favor, respectively, the translocation of CSCs-ECCs from the surrounding myocardium to the dead tissue and the viability and growth of these cells within the damaged area. To facilitate migration and homing of CSCs-ECCs to the infarct, a growth factor gradient was introduced between the site of storage of primitive cells in the atria and the region bordering the infarct. The newly-formed myocardium contained arterioles, capillaries, and functionally competent myocytes that with time increased in size, improving ventricular performance at healing and long thereafter. The volume of regenerated myocytes was 2200 m3 at 16 days after treatment and reached 5100 m3 at 4 months. In this interval, nearly 20% of myocytes reached the adult phenotype, varying in size from 10 000 to 20 000 m3. Moreover, there were 4313 arterioles and 15548 capillaries/mm2 myocardium at 16 days, and 316 arterioles and 39056 capillaries at 4 months. Myocardial regeneration induced increased survival and rescued animals with infarcts that were up to 86% of the ventricle, which are commonly fatal. In conclusion, the heart has an endogenous reserve of CSCs-ECCs that can be activated to reconstitute dead myocardium and recover cardiac function

    Weight management interventions in adults with intellectual disabilities and obesity: a systematic review of the evidence

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    o evaluate the clinical effectiveness of weight management interventions in adults with intellectual disabilities (ID) and obesity using recommendations from current clinical guidelines for the first line management of obesity in adults. Full papers on lifestyle modification interventions published between 1982 to 2011 were sought by searching the Medline, Embase, PsycINFO and CINAHL databases. Studies were evaluated based on 1) intervention components, 2) methodology, 3) attrition rate 4) reported weight loss and 5) duration of follow up. Twenty two studies met the inclusion criteria. The interventions were classified according to inclusion of the following components: behaviour change alone, behaviour change plus physical activity, dietary advice or physical activity alone, dietary plus physical activity advice and multi-component (all three components). The majority of the studies had the same methodological limitations: no sample size justification, small heterogeneous samples, no information on randomisation methodologies. Eight studies were classified as multi-component interventions, of which one study used a 600 kilocalorie (2510 kilojoule) daily energy deficit diet. Study durations were mostly below the duration recommended in clinical guidelines and varied widely. No study included an exercise program promoting 225–300 minutes or more of moderate intensity physical activity per week but the majority of the studies used the same behaviour change techniques. Three studies reported clinically significant weight loss (≥ 5%) at six months post intervention. Current data indicate weight management interventions in those with ID differ from recommended practice and further studies to examine the effectiveness of multi-component weight management interventions for adults with ID and obesity are justified

    Assessment of nitrous oxide emission from cement plants: Real data measured with both Fourier transform infrared and nondispersive infrared techniques

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    Nitrous oxide (N2O) is the third most important greenhouse gas after carbon dioxide and methane, and contributes about 6% to the greenhouse effect. Nitrous oxide is a minor component of the atmosphere, and it is a thousand times less than carbon dioxide (CO2). Nevertheless, it is much more potent than CO2 and methane, owing to its long stay in the atmosphere of approximately 120 yr and the high global warming potential (GWP) of 298 times that of CO2. Although greenhouse gases are natural in the atmosphere, human activities have changed the atmospheric concentrations. Most of the values of emission of nitrous oxide are still obtained by means of emission factors and not actually measured; the lack of real data may result in an underestimation of current emissions. The emission factors used for the calculation of N2O can be obtained from the "Guidelines for the implementation of the national inventory of emissions" of the Intergovernmental Panel on Climate Change, which refer to all nations for the realization of their inventory. This study will present real data, measured in several Italian cement plants with different characteristics. The work also shows a comparison between N2O concentration measured with in situ Fourier transform IR (FTIR) and the reference method EN ISO 21258 based on nondispersive IR (NDIR), in order to investigate the interfering compounds in the measurement with NDIR. [GRAPHICS

    Long-term automated sampling of PCDD/PCDF flue gas: current status and critical issues

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    After entry into force of the Stockholm Convention and Aarhus Protocol and in order to implement the upcoming European legal background, the European countries are asked to apply control measures to reduce the release of persistent organic pollutants (POPs) such as dioxins and furans (PCDD/PCDF) and polychlorinated biphenyls as well as to establish POPs release inventories. In this perspective, development of measuring techniques of emissions is a focal issue in acquiring useful information. In this paper, results of various measurement campaigns at different municipal waste incineration (MWI) plants using long-term automated sampling of PCDD/PCDF are presented. The samples collected from both manual and automated campaigns were analyzed following the European Standard EN-1948:2006 by high-resolution gas chromatograph/high-resolution mass spectrometer. Performances of two different commercial systems have been investigated. Anomalous values occurred during one long-term campaign (22.16 pg I-toxic equivalent (TEQ)/Nm(3)), compared to average values (4-5 pg I-TEQ/Nm(3)) of the MWI. At this maximum value, a main occurrence of abnormal and instable operating conditions has been found. Sampling based on long-term basis was found to be more reliable to monitor PCDD/PCDF emissions than occasional short-term sampling. Nevertheless, the results of long-term campaigns demonstrate that emission levels detected in 15-30 days campaigns, when unsteady operating conditions can occur, as start-up and shut down, are not immediately comparable to the typical levels in a 6-8 h, when operating conditions are generally stable. Moreover, there are often differences observed in the congener profiles between short- and long-term campaigns

    Polycyclic aromatic hydrocarbons formation in sludge incineration by fluidised bed and rotary kiln furnace

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    Polycyclic Aromatic Hydrocarbons (PAHs) are typical pollutants arising from incineration. They are produced in any incomplete combustion principally due to inhomogeneities in a combustion chamber. The effects of the afterburning temperature on PAHs formation during sewage sludge incineration are discussed in this paper. Tests were performed inside the area of the wastewater treatment plant of 'Bari Ovest' on a demonstrative plant (maximum throughput 250 kg hr(-1) of dewatered sludge at 20% solids concentration) equipped with a fluidised bed furnace (FBF) and a rotary kiln furnace (RKF) where sewage sludge was fed, either as it was taken from the dewatering section of the wastewater treatment plant, or previously spiked by different dosages of chlorinated hydrocarbons. Exhaust gases were sampled before the bag filter, where the pollutants can be considered representative of those arising from the process. Parallel sampling of flue gas at the stack was also carried out. In the FBF tests with sludge spiked with high dosages of chlorinated hydrocarbons highest values of PAHs concentrations (> 3.9 mug Nm(-3)) were detected before filtration, when the afterburning chamber was not in use. The operation of the afterburning chamber, at a temperature higher than 900degreesC, allows to partially suppress PAHs formation up to values of 0.9 - 3.2 mug Nm(-3). PAHs removal efficiency of the exhaust gas treatment was calculated with a mean value for all the test of 72%. In RKF tests PAHs displayed much lower values before filtration ( range 0.04 - 2.98 mug Nm(-3), mean value 0.51 mug Nm(-3)) probably due to the longer gas residence time in the furnace (> 6 s in comparison with values < 2 s in fluidised bed furnace). Surprisingly, for RKF tests PAHs removal efficiency of gas treatment appeared quite unstable: some tests evidenced PAHs stripping in the scrubber, where the effluent of the wastewater treatment plant was used. No correlation was observed in RKF tests between PAHs concentration before the bag filter and the temperature of the afterburning chamber

    Dioxins and furans formation in pilot incineration tests of sewage sludge spiked with organic chlorine

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    The factors affecting polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) formation were studied in sewage sludge incineration tests carried out on a demonstrative plant. The plant includes a circulating fluidised bed furnace (FBF) and a rotary kiln furnace (RKF), operating alternatively. During the tests sewage sludge was spiked with chlorinated hydrocarbons and the operating parameters of the afterburning chamber were varied. PCDD/F were sampled in each test before the bag filter, thus collecting the above contaminants before abatement systems. From the tests it appeared that PCDD/F were always produced in more abundance in the tests carried out by FBF than by RKF. The higher PCDD/F concentrations in the tests by FBF were reached when sewage sludge was spiked with a high dosage of a surrogate organic mixture of chlorinated hydrocarbons and when the afterburning chamber was used only as transit equipment with the burner off. The distribution of the different PCDD/F homologues was compared. P(5)CDFs were generally the prevalent fraction, with very few exceptions for the tests by RKF at high temperature of the afterburning chamber. As for FBF tests, it was found that the PCDD/F homologue profile depends on the afterburning chamber temperature. (C) 2003 Elsevier Ltd. All rights reserved
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