The Most Dangerous Game

Sandwiched between the post-medium condition, and the potential erasure of all traditional media coming from the digital horizon, Michaël Borremans delivers highly constructed paintings and films that negotiate temporal disjunctions and intermedial relations together with an expanded form of exhibition. This article sets out to unpick some of the underlying mechanisms at play beneath the surface of his work, and to uncover some of the reasons why it might be deemed to be relevant; a question the artist himself appears to be at pains to answer

Approximate Controllability, Exact Controllability, and Conical Eigenvalue Intersections for Quantum Mechanical Systems

International audienceWe study the controllability of a closed control-affine quantum system driven by two or more external fields. We provide a sufficient condition for controllability in terms of existence of conical intersections between eigenvalues of the Hamiltonian in dependence of the controls seen as parameters. Such spectral condition is structurally stable in the case of three controls or in the case of two controls when the Hamiltonian is real. The spectral condition appears naturally in the adiabatic control framework and yields approximate controllability in the infinite-dimensional case. In the finite-dimensional case it implies that the system is Lie-bracket generating when lifted to the group of unitary transformations, and in particular that it is exactly controllable. Hence, Lie algebraic conditions are deduced from purely spectral properties. We conclude the article by proving that approximate and exact controllability are equivalent properties for general finite-dimensional quantum systems

Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer Development

Ubiquitination and ubiquitin-like post-translational modifications control the activity and stability of different tumor suppressors and oncoproteins. Hence, regulation of this enzymatic cascade offers an appealing scenario for novel antineoplastic targets discovery. Among the different families of enzymes that participate in the conjugation of Ubiquitin, deubiquitinating enzymes (DUBs), responsible for removing ubiquitin or ubiquitin-like peptides from substrate proteins, have attracted increasing attention. In this regard, increasing evidence is accumulating suggesting that the modulation of the catalytic activity of DUBs represents an attractive point of therapeutic intervention in cancer treatment. In particular, different lines of research indicate that USP19, a member of the DUBs, plays a role in the control of tumorigenesis and cancer dissemination. This review aims at summarizing the current knowledge of USP19 wide association with the control of several cellular processes in different neoplasms, which highlights the emerging role of USP19 as a previously unrecognized prognosis factor that possesses both positive and negative regulation activities in tumor biology. These observations indicate that USP19 might represent a novel putative pharmacologic target in oncology and underscores the potential of identifying specific modulators to test in clinical settings.Fil: Rossi, Fabiana Alejandra. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Rossi, Mario. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentin

Seasonally steady planetary disturbances in the troposphere and stratosphere as seen in 30 years of NCEP reanalysis data

Zonal velocity and temperature daily global reanalysis data of 30 years are used to search seasonally steady planetary disturbances in the middle troposphere (400 hPa) and middle stratosphere (10 hPa). Significant wavenumber 1, 2 and 3 modes are found. Constant phase lines of zonal velocity 1 modes exhibit significant inclination angles with respect to the meridians. The winter hemisphere generally shows a more significant presence of structures. The Northern Hemisphere (NH) exhibits all over the year a larger amount of structures and more intense amplitudes than the Southern Hemisphere (SH). Middle latitudes exhibit the most significant cases and low latitudes the least significant ones. Longitudinally oriented land-sea transitions at +- 65 deg and -35 deg latitudes appear to play a significant role for the presence of steady planetary modes. The stratosphere exhibits a much simpler picture than the troposphere. Large scale structures with respectively NE-SW (NH) and NW-SE (SH) tilts in the observed temperature and zonal velocity constant phase lines recall the quasi-stationary Rossby wave trains that favor the poleward transport of angular momentum.Fil: Alexander, Pedro Manfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires; Argentina;Fil: Rossi, Mario. Universidad de Buenos Aires; Argentina

Experimental generation of entanglement from classical correlations via non-unital local noise

We experimentally show how classical correlations can be turned into quantum entanglement, via the presence of non-unital local noise and the action of a CNOT gate. We first implement a simple two-qubit protocol in which entanglement production is not possible in the absence of local non-unital noise, while entanglement arises with the introduction of noise, and is proportional to the degree of noisiness. We then perform a more elaborate four-qubit experiment, by employing two hyperentangled photons initially carrying only classical correlations. We demonstrate a scheme where the entanglement is generated via local non-unital noise, with the advantage to be robust against local unitaries performed by an adversary.Comment: 8 pages, 4 figure

Identifying and Modelling Complex Workflow Requirements in Web Applications

Workflow plays a major role in nowadays business and therefore its requirement elicitation must be accurate and clear for achieving the solution closest to business’s needs. Due to Web applications popularity, the Web is becoming the standard platform for implementing business workflows. In this context, Web applications and their workflows must be adapted to market demands in such a way that time and effort are minimize. As they get more popular, they must give support to different functional requirements but also they contain tangled and scattered behaviour. In this work we present a model-driven approach for modelling workflows using a Domain Specific Language for Web application requirement called WebSpec. We present an extension to WebSpec based on Pattern Specifications for modelling crosscutting workflow requirements identifying tangled and scattered behaviour and reducing inconsistencies early in the cycle

An integrated geodetic and InSAR technique for the monitoring and detection of active faulting in southwestern Sicily

We present the results of the analysis of GNSS (Global Navigation Satellite System) and InSAR (Interferometric synthetic-aperture radar) data collected in the frame of a project financed by the “Struttura Terremoti” of INGV (Istituto Nazionale di Geofisica e Vulcanologia). Combined investigations pointed out for potential seismogenic sources for destructive earthquakes recorded in southwestern Sicily, including the 1968 Belice earthquake sequence and that supposed to have destroyed the Greek city of Selinunte which, according to geoarcheological data experienced two earthquakes in historical times. Our approach is aimed to evaluate the current deformation rate in SW Sicily and to improve the knowledge about the seismic potential of this area. The geodetic data proposed in this paper show that the Campobello di Mazara–Castelvetrano alignment (CCA) is currently deforming with a vertical and horizontal displacements of 2 mm/yr and 0.5 mm/yr respectively, according to the tectonic setting of the are