5,902 research outputs found
Performance of commercial corn hybrids in Illinois, 1975, with 1973 and 1974 listings / 1118
Chiefly tables
Pre-Revolutionary Popular Constitutionalism and Larry Kramer\u27s \u3cem\u3eThe People Themselves\u3c/em\u3e
Larry Kramer\u27s depiction of pre-Revolutionary constitutionalism rests on two dichotomies that are valuable yet exclude middle positions. First, he distinguishes between fundamental law and ordinary law. Second, he argues that pre-Revolutionary judges could play one of two roles—since they were not supreme constitutional interpreters (the first of these roles), they must have possessed no special authority to determine constitutional meanings (the second, and remaining, possibility). Both of these dichotomies obscure middle positions that capture important aspects of the pre-Revolutionary constitutional tradition. My comments briefly identify these middle positions and suggest what is at stake in recovering them
Pre-Revolutionary Popular Constitutionalism and Larry Kramer\u27s \u3cem\u3eThe People Themselves\u3c/em\u3e
Larry Kramer\u27s depiction of pre-Revolutionary constitutionalism rests on two dichotomies that are valuable yet exclude middle positions. First, he distinguishes between fundamental law and ordinary law. Second, he argues that pre-Revolutionary judges could play one of two roles—since they were not supreme constitutional interpreters (the first of these roles), they must have possessed no special authority to determine constitutional meanings (the second, and remaining, possibility). Both of these dichotomies obscure middle positions that capture important aspects of the pre-Revolutionary constitutional tradition. My comments briefly identify these middle positions and suggest what is at stake in recovering them
Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol : a pilot study
Background: Incidental adrenal masses are commonly detected during imaging for other pathologies. 10% of the elderly
population has an ‘adrenal incidentaloma’, up to 20% of these show low-grade autonomous cortisol secretion and 60% of
patients with autonomous cortisol secretion have insulin resistance. Cortisol excess is known to cause insulin resistance, an
independent cardiovascular risk marker, however in patients with adrenal incidentalomas it is unknown whether their
insulin resistance is secondary to the excess cortisol and therefore potentially reversible. In a proof of concept study we
examined the short-term effects of glucocorticoid receptor (GR) antagonism in patients with an adrenal incidentaloma to
determine whether their insulin resistance was reversible.
Methodology/Principal Findings: In a prospective open-label pilot study, six individuals with adrenal incidentalomas and
autonomous cortisol secretion were treated with mifepristone (a GR antagonist) 200 mg twice daily and studied for 4 weeks
on a Clinical Research Facility. Insulin resistance at four weeks was assessed by insulin resistance indices, lnHOMA-IR and
lnMatsuda, and AUC insulin during a 2-hour glucose tolerance test. Biochemical evidence of GR blockade was shown in all
individuals and across the group there was a significant reduction in insulin resistance: lnHOMA-IR (1.0vs0.6; p = 0.03),
lnHOMA-%beta (4.8vs4.3; p = 0.03) and lnMatsuda (1.2vs1.6; p = 0.03). Five out of six individuals showed a reduction in
insulin AUC .7237 pmol/l.min, and in two patients this showed a clinically significant cardiovascular benefit (as defined by
the Helsinki heart study).
Conclusions: Short-term GR antagonism is sufficient to reduce insulin resistance in some individuals with adrenal
incidentalomas and mild cortisol excess. Further assessment is required to assess if the responses may be used to stratify
therapy as adrenal incidentalomas may be a common remediable cause of increased cardiovascular risk
Supernova enrichment and dynamical histories of solar-type stars in clusters
We use N-body simulations of star cluster evolution to explore the hypothesis
that short-lived radioactive isotopes found in meteorites, such as 26-Al, were
delivered to the Sun's protoplanetary disc from a supernova at the epoch of
Solar System formation. We cover a range of star cluster formation parameter
space and model both clusters with primordial substructure, and those with
smooth profiles. We also adopt different initial virial ratios - from cool,
collapsing clusters to warm, expanding associations. In each cluster we place
the same stellar population; the clusters each have 2100 stars, and contain one
massive 25M_Sun star which is expected to explode as a supernova at about
6.6Myr. We determine the number of Solar (G)-type stars that are within 0.1 -
0.3pc of the 25M_Sun star at the time of the supernova, which is the distance
required to enrich the protoplanetary disc with the 26-Al abundances found in
meteorites. We then determine how many of these G-dwarfs are unperturbed
`singletons'; stars which are never in close binaries, nor suffer sub-100au
encounters, and which also do not suffer strong dynamical perturbations.
The evolution of a suite of twenty initially identical clusters is highly
stochastic, with the supernova enriching over 10 G-dwarfs in some clusters, and
none at all in others. Typically only ~25 per cent of clusters contain
enriched, unperturbed singletons, and usually only 1 - 2 per cluster (from a
total of 96 G-dwarfs in each cluster). The initial conditions for star
formation do not strongly affect the results, although a higher fraction of
supervirial (expanding) clusters would contain enriched G-dwarfs if the
supernova occurred earlier than 6.6Myr. If we sum together simulations with
identical initial conditions, then ~1 per cent of all G-dwarfs in our
simulations are enriched, unperturbed singletons.Comment: 14 pages, 5 figures, accepted for publication in MNRA
Instantaneous Pair Theory for High-Frequency Vibrational Energy Relaxation in Fluids
Notwithstanding the long and distinguished history of studies of vibrational
energy relaxation, exactly how it is that high frequency vibrations manage to
relax in a liquid remains somewhat of a mystery. Both experimental and
theoretical approaches seem to say that there is a natural frequency range
associated with intermolecular motions in liquids, typically spanning no more
than a few hundred cm^{-1}. Landau-Teller-like theories explain how a solvent
can absorb any vibrational energy within this "band", but how is it that
molecules can rid themselves of superfluous vibrational energies significantly
in excess of these values? We develop a theory for such processes based on the
idea that the crucial liquid motions are those that most rapidly modulate the
force on the vibrating coordinate -- and that by far the most important of
these motions are those involving what we have called the mutual nearest
neighbors of the vibrating solute. Specifically, we suggest that whenever there
is a single solvent molecule sufficiently close to the solute that the solvent
and solute are each other's nearest neighbors, then the instantaneous
scattering dynamics of the solute-solvent pair alone suffices to explain the
high frequency relaxation. The many-body features of the liquid only appear in
the guise of a purely equilibrium problem, that of finding the likelihood of
particularly effective solvent arrangements around the solute. These results
are tested numerically on model diatomic solutes dissolved in atomic fluids
(including the experimentally and theoretically interesting case of I_2 in Xe).
The instantaneous pair theory leads to results in quantitative agreement with
those obtained from far more laborious exact molecular dynamics simulations.Comment: 55 pages, 6 figures Scheduled to appear in J. Chem. Phys., Jan, 199
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