Bioactive Herbal Medicine Use for Eye Sight: A Meta Analysis

The use of chemical medications to treat eye conditions in a way that avoids causing harm is still a work in progress for modern medicine. Herbal remedies, however, may be able to solve the problems that conventional pharmaceuticals have. Given their efficacy, lack of adverse effects, and inexpensive cost, there have been extensive efforts to discover novel medicinal plants from various locations. Several plant species have been promoted in Traditional Indian Medicine for their ophthalmic effects, and it is estimated that around 200 plants worldwide have been documented to support therapy of eye problems. This review seeks to shed light on the history of using various plants to treat eye illnesses, the advantages and disadvantages of those approaches, and the advantages of modern medicine over those of the plants themselves. Based on the findings of this review, the most effective Ayurvedic preparations may be created by combining traditional knowledge with modern techniques and polymers

CLINICAL PROFILE AND THE OUTCOME OF COVID-19 IN PATIENTS WITH HEMATOLOGICAL MALIGNANCY: A SINGLE CENTRE EXPERIENCE

Objective: In the present study, we are reporting the clinical profile; and outcomes of COVID-19 in patients with hematological malignancy at tertiary care hospitals. Methods: Data from laboratory-confirmed 40 COVID-19 patients diagnosed between January 1, 2021 and July 31, 2021, were analyzed retrospectively. All COVID-19 patients with hematological malignancy (n=40) were included in the study. Results: In the present study, a total of 40 patients were included. Of 40, 25 (62.5%) were males, and 15 (37.5%) were females. The median age in this study was 43 years (Range, 8–70). Of these 40 patients, acute myeloid leukemia was the most common malignancy 11 (27.5%), followed by acute lymphoblastic leukemia 9 (22.5%) than non-Hodgkin lymphoma 5 (12.5%), plasma cell dyscrasia 4 (10%), chronic myeloid leukemia 4 (10%), chronic lymphocytic leukemia 3 (7.5%), acute promyelocytic leukemia 2 (5%), chronic myelomonocytic leukemia 2 (5%). Mean hemoglobin was (8.04 g/dl), white blood cell count was (10.14×109/l), platelet count was (77.7×109/l) creatinine was (0.86 mg/dl), bilirubin was (1.24 mg/dl). The overall case-fatality rate was 8 (22.5%). Conclusion: Patients with hematological malignancy are immunocompromised, and our study reveals that there is an increased case fatality rate among these patients. Hence, physicians should be aggressive in the management of COVID‐19 patients with hematological malignancy

Exploring synergies and trade-offs among the sustainable development goals: collective action and adaptive capacity in marginal mountainous areas of India

Global environmental change (GEC) threatens to undermine the sustainable development goals (SDGs). Smallholders in marginal mountainous areas (MMA) are particularly vulnerable due to precarious livelihoods in challenging environments. Acting collectively can enable and constrain the ability of smallholders to adapt to GEC. The objectives of this paper are: (i) identify collective actions in four MMA of the central Indian Himalaya Region, each with differing institutional contexts; (ii) assess the adaptive capacity of each village by measuring livelihood capital assets, diversity, and sustainable land management practices. Engaging with adaptive capacity and collective action literatures, we identify three broad approaches to adaptive capacity relating to the SDGs: natural hazard mitigation (SDG 13), social vulnerability (SDG 1, 2 and 5), and social–ecological resilience (SDG 15). We then develop a conceptual framework to understand the institutional context and identify SDG synergies and trade-offs. Adopting a mixed method approach, we analyse the relationships between collective action and the adaptive capacity of each village, the sites where apparent trade-offs and synergies among SDGs occur. Results illustrate each village has unique socio-environmental characteristics, implying distinct development challenges, vulnerabilities and adaptive capacities exist. Subsequently, specific SDG synergies and trade-offs occur even within MMA, and it is therefore crucial that institutions facilitate locally appropriate collective actions in order to achieve the SDGs. We suggest that co-production in the identification, prioritisation and potential solutions to the distinct challenges facing MMA can increase understandings of the specific dynamics and feedbacks necessary to achieve the SDGs in the context of GEC

Analytical method Development and validation of Ivabradine by using RP-HPLC

The RP-HPLC method, which makes use of an XTERR C8 column (150mm × 4.6mm, 3.5μm) and a mobile phase of acetonitrile:0.01N KH2PO4(60:40) of HPLC grade, became created and accepted to be used in Ivabradine analysis. Buffer's pH became stored at 3. After being subjected to a 10-minute sonication, the use of a 0.45μm Nylon clear out, A 0.9mL/min waft charge became used to clear out the cellular section. After 260 nm of detection, it became observed that Ivabradine had a 1.846-minute retention period. Linearity became found with equation y=14200x+106895, from 80–120 μg/mL (R2 became the coefficient of determination). ICH hints had been accompanied with inside the validation of the approach

Drug-eluting stents appear superior to bare metal stents for vein-graft PCI in vessels up to a stent diameter of 4 mm.

BACKGROUND: Research trials have shown improved short-term outcome with drug-eluting stents (DES) over bare metal stents (BMS) in saphenous vein graft (SVG) percutaneous coronary intervention (PCI), primarily by reducing target vessel revascularization (TVR) for in-stent restenosis. We compared the outcomes in patients undergoing SVG stent implantation treated with DES or BMS. In exploratory analyses we investigated the influence of stent generation and diameter. METHODS: Data were obtained from a prospective database of 657 patients who underwent PCI for SVG lesions between 2003 and 2011. A total of 344 patients had PCI with BMS and 313 with DES. Propensity scores were developed based on 15 observed baseline covariates in a logistic regression model with stent type as the dependent variable. The nearest-neighbour-matching algorithm with Greedy 5-1 Digit Matching was used to produce two patient cohorts of 313 patients each. We assessed major adverse cardiac events (MACE) out to a median of 3.3 years (interquartile range: 2.1-4.1). MACE was defined as all-cause mortality, myocardial infarction (MI), TVR and stroke. RESULTS: There was a significant difference in MACE between the two groups in favour of DES (17.9% DES vs. 31.2% BMS group; p = 0.0017) over the 5-year follow-up period. MACE was driven by increased TVR in the BMS group. There was no difference in death, MI or stroke. Adjusted Cox analysis confirmed a decreased risk of MACE for DES compared with BMS 0.75 (95% confidence interval (CI) 0.52-0.94), with no difference in the hazard of all-cause mortality (hazard ratio: 1.08; 95% CI: 0.77-1.68). However, when looking at stent diameters greater than 4 mm, no difference was seen in MACE rates between BMS and DES. CONCLUSIONS: Overall in our cohort of patients who had PCI for SVG disease, DES use resulted in lower MACE rates compared with BMS over a 5-year follow-up period; however, for stent diameters over 4 mm no difference in MACE rates was seen

IoTCom: Automating The Development of Communication Channels For Internet of Things Applications

With the introduction of Internet Of Things (IoT), a technologically advanced place to live with all the devices connected in a network is no longer an imagination. The development of an IoT application generally involves developing a set of software components (e.g., the embedded controller running in the IoT device, the web server running in the cloud, the mobile client running in the smart phone), as well as building the reliable communication channels to connect these components. To add to it, different IoT applications and platforms require different implementation (e.g., protocols, libraries, programming language) for the communication channels, which makes it really challenging for the developers to master all the options and build the correct implementation. We are working on a model-based framework - IoTCom to automate the development of communication channels used in the context of IoT, in order to accelerate the development and ensure a consistent application quality. In this way, the developers can access a plug-n-play kind of framework and customize their applications as per requirements

Water security and spring conservation in the Himalaya

Springs are the most important source of water for the people in the mid-hills of the Himalaya. Emerging evidence shows that they are increasingly drying up, causing numerous hardships for people, with those impacts being felt more acutely by women and members of vulnerable communities like lower castes (Dalits). Climate change, land-use and land cover changes, including haphazard infrastructure (hydropower, road construction), and other socio-economic changes such as urbanization and tourism are the leading causes of the drying up of springs. In the region in general, and India in particular, the last decade and a half have seen increased initiatives for spring revival. In this chapter, we document the genesis of some of these spring revival initiatives in India and note how all stakeholders—communities, civil societies and governments have come to support spring revival initiatives. We also note that the scientific community has not yet caught up with the action on the ground, and we still lack rigorous documentation of the short and long-term effectiveness of spring revival initiatives. We recommend integrating scientific knowledge with social analysis on the governance aspects for improving spring recharge, better management and postulating potential responses of natural and human systems against future climate change impacts in the Himalaya