20 research outputs found

    Epilogue

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    Epilogue

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    Neuromodulation of glial function during neurodegeneration

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    Glia, a non-excitable cell type once considered merely as the connective tissue between neurons, is nowadays acknowledged for its essential contribution to multiple physiological processes including learning, memory formation, excitability, synaptic plasticity, ion homeostasis, and energy metabolism. Moreover, as glia are key players in the brain immune system and provide structural and nutritional support for neurons, they are intimately involved in multiple neurological disorders. Recent advances have demonstrated that glial cells, specifically microglia and astroglia, are involved in several neurodegenerative diseases including Amyotrophic lateral sclerosis (ALS), Epilepsy, Parkinson’s disease (PD), Alzheimer’s disease (AD), and frontotemporal dementia (FTD). While there is compelling evidence for glial modulation of synaptic formation and regulation that affect neuronal signal processing and activity, in this manuscript we will review recent findings on neuronal activity that affect glial function, specifically during neurodegenerative disorders. We will discuss the nature of each glial malfunction, its specificity to each disorder, overall contribution to the disease progression and assess its potential as a future therapeutic target

    Between opportunity and challenge : Mayors' perspective on participatory heritage practices in World Heritage Cities

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    The participation of multiple stakeholders, communities, groups, and individuals in heritage processes is considered an important component of good heritage governance, which presents diverse challenges and opportunities. Much research has explored the communities, researchers, and practitioners’ perceptions of these challenges and opportunities, offering insights into current practices. However, little research has investigated governmental actors’ perceptions, mainly focusing on specific cases, without comparing their perspectives across regions. To address this gap, during the 2017 OWHC XIV World Congress, a Mayors’ workshop was organized to unveil the perceptions that WH cities’ representatives have of the strengths, weaknesses, opportunities, and threats (SWOT) of participatory heritage practices in their World Heritage cities. Results revealed strong interconnections among the different SWOT elements, as well as commonalities and differences among cities worldwide. Participation itself emerged as the most mentioned element across the SWOT, highlighting the strong influence that the factors affecting it have over the positive or negative outcomes of participatory heritage practices

    Epilogue

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