Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts.

Neural progenitor cell grafts form new relays across sites of spinal cord injury (SCI). Using a panel of neuronal markers, we demonstrate that spinal neural progenitor grafts to sites of rodent SCI adopt diverse spinal motor and sensory interneuronal fates, representing most neuronal subtypes of the intact spinal cord, and spontaneously segregate into domains of distinct cell clusters. Host corticospinal motor axons regenerating into neural progenitor grafts innervate appropriate pre-motor interneurons, based on trans-synaptic tracing with herpes simplex virus. A human spinal neural progenitor cell graft to a non-human primate also received topographically appropriate corticospinal axon regeneration. Thus, grafted spinal neural progenitor cells give rise to a variety of neuronal progeny that are typical of the normal spinal cord; remarkably, regenerating injured adult corticospinal motor axons spontaneously locate appropriate motor domains in the heterogeneous, developing graft environment, without a need for additional exogenous guidance

The Future of Corporate Tax Reform: A Debate

Professor Geier participated in a Lincoln-Douglas style debate, where the debaters were assigned different roles, so the opinions expressed were not necessarily their own. On the first point debated, Professor Geier was assigned to argue: The Affirmative: We Need to Tax Corporationsat the Entity Level. Others argued the negative: The United States Should Repeal the Corporate Income Tax. On the second point debated, Professor Geier argued the negative, that Dividend Exemption Is NOT the Best Method of Corporate/Shareholder Integration, and is in fact the worst method. On the third point, Professor Geier argued in the affirmative, that the corporate tax rate should be lowered to below 35% in a revenue neutral way

The Future of Corporate Tax Reform: A Debate

Professor Geier participated in a Lincoln-Douglas style debate, where the debaters were assigned different roles, so the opinions expressed were not necessarily their own. On the first point debated, Professor Geier was assigned to argue: The Affirmative: We Need to Tax Corporationsat the Entity Level. Others argued the negative: The United States Should Repeal the Corporate Income Tax. On the second point debated, Professor Geier argued the negative, that Dividend Exemption Is NOT the Best Method of Corporate/Shareholder Integration, and is in fact the worst method. On the third point, Professor Geier argued in the affirmative, that the corporate tax rate should be lowered to below 35% in a revenue neutral way

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury.

Although axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, we administered C7 spinal cord hemisections to adult rhesus monkeys and analyzed behavioral, electrophysiological and anatomical adaptations. We found marked spontaneous plasticity of corticospinal projections, with reconstitution of fully 60% of pre-lesion axon density arising from sprouting of spinal cord midline-crossing axons. This extensive anatomical recovery was associated with improvement in coordinated muscle recruitment, hand function and locomotion. These findings identify what may be the most extensive natural recovery of mammalian axonal projections after nervous system injury observed to date, highlighting an important role for primate models in translational disease research

Desulfosporosinus lacus sp. nov., a sulfate-reducing bacterium isolated from pristine freshwater lake sediments

A novel sulfate-reducing bacterium was isolated from pristine sediments of Lake Stechlin, Germany. This strain, STP12 , was found to contain predominantly c-type cytochromes and to reduce sulfate, sulfite and thiosulfate using lactate as an electron donor. Although STP12 could not utilize elemental sulfur as an electron acceptor, it could support growth by dissimilatory Fe(III) reduction. In a comparison of 16S rRNA gene sequences, STP12 was 96.7 % similar to Desulfosporosinus auripigmenti DSM 13351 , 96.5 % similar to Desulfosporosinus meridiei DSM 13257 and 96.4 % similar to Desulfosporosinus orientis DSM 765 . DNA-DNA hybridization experiments revealed that strain STP12 shows only 32 % reassociation with the type strain of the type species of the genus, D. orientis DSM 765 . These data, considered in conjunction with strain-specific differences in heavy metal tolerance, cell-wall chemotaxonomy and riboprint patterns, support recognition of strain STP12 (=DSM 15449 =JCM 12239 ) as the type strain of a distinct and novel species within the genus Desulfosporosinus, Desulfosporosinus lacus sp. nov. © 2006 IUMS. T T T T T T T T T T

Desulfovibrio idahonensis sp. nov., sulfatereducing bacteria isolated from a metal(loid)-contaminated freshwater sediment

Two novel sulfate-reducing bacteria, strains CY1 and CY2, were isolated from heavy-metal-contaminated sediments of Lake Coeur d\u27Alene, Idaho, USA. Strains CY1 and CY2 were found to contain c-type cytochromes and to reduce sulfate, sulfite, thiosulfate, elemental sulfur, DMSO, anthraquinone disulfonate and fumarate using lactate as an electron donor. In a comparison of 16S rRNA gene sequences, CY1 and CY2 were found to be 100% identical, but only 97 and 92.4% similar, respectively, to the type strains of Desulfovibrio mexicanus and Desulfovibrio aminophilus. Unlike these species, however, CY1 was neither able to disproportionate thiosulfate nor able to use yeast extract or amino acids as electron donors. These data, considered in conjunction with differences among strain CY1 and the two related type strains in chemotaxonomy, riboprint patterns, temperature and pH optima, support recognition of a distinct and novel species within the genus Desulfovibrio, Desulfovibrio idahonensis sp. nov., with the type strain CY1 (=DSM 15450 =JCM 14124 ). © 2009 IUMS. T T T T T T T

Progress on the hybrid gun project at UCLA

UCLA/INFN-LNF/Univ. Rome has been developing the hybrid gun which has an RF gun and a short linac for velocity bunching in one structure. After the cavity was manufactured at INFN-LNF in 2012, tests of the gun was carried out at UCLA. The field in the standing wave part was 20 % smaller than the simulation but the phase advance was fine. The cavity was commissioned successfully up to 13 MW. The beam test was performed at 11.5 MW and demonstrated the bunch compression

The value of paleoecology as an aid to monitoring ecosystems and landscapes, chiefly with reference to North America

Paleoecological indicators are examined as to their accuracy in reconstructing past biotic communities and environmental conditions, their utility in answering important questions about such communities and conditions, and the temporal and spatial scales over which they are effective. Next, environmental problems susceptible of paleoecological analysis are considered, as are the ecosystem and landscape properties that can be inferred from such an analysis. The usefulness of paleoecology in anticipating ecological surprises is then discussed. Finally, a set of conclusions and recommendations is presented

Observation of Plasma Focusing of a 28.5 GeV Positron Beam

The observation of plasma focusing of a 28.5 GeV positron beam is reported. The plasma was formed by ionizing a nitrogen jet only 3 mm thick. Simultaneous focusing in both transverse dimensions was observed with effective focusing strengths of order Tesla per micron. The minimum area of the beam spot was reduced by a factor of 2.0 +/- 0.3 by the plasma. The longitudinal beam envelope was measured and compared with numerical calculations