11,140 research outputs found
Inhibition of browning in foodstuffs
Addition of water-soluble sulfur-containing compounds, thio compounds or potential thio compounds, to a mixture of carbohydrates, and either proteins, peptides, or amino acids can retard or completely eliminate the browning process. Determining factor is dependent upon the concentration of the anti-browning agent in the aqueous media
Smooth Inequalities and Equilibrium Inefficiency in Scheduling Games
We study coordination mechanisms for Scheduling Games (with unrelated
machines). In these games, each job represents a player, who needs to choose a
machine for its execution, and intends to complete earliest possible. Our goal
is to design scheduling policies that always admit a pure Nash equilibrium and
guarantee a small price of anarchy for the l_k-norm social cost --- the
objective balances overall quality of service and fairness. We consider
policies with different amount of knowledge about jobs: non-clairvoyant,
strongly-local and local. The analysis relies on the smooth argument together
with adequate inequalities, called smooth inequalities. With this unified
framework, we are able to prove the following results.
First, we study the inefficiency in l_k-norm social costs of a strongly-local
policy SPT and a non-clairvoyant policy EQUI. We show that the price of anarchy
of policy SPT is O(k). We also prove a lower bound of Omega(k/log k) for all
deterministic, non-preemptive, strongly-local and non-waiting policies
(non-waiting policies produce schedules without idle times). These results
ensure that SPT is close to optimal with respect to the class of l_k-norm
social costs. Moreover, we prove that the non-clairvoyant policy EQUI has price
of anarchy O(2^k).
Second, we consider the makespan (l_infty-norm) social cost by making
connection within the l_k-norm functions. We revisit some local policies and
provide simpler, unified proofs from the framework's point of view. With the
highlight of the approach, we derive a local policy Balance. This policy
guarantees a price of anarchy of O(log m), which makes it the currently best
known policy among the anonymous local policies that always admit a pure Nash
equilibrium.Comment: 25 pages, 1 figur
Interactions of technology and society: Impacts of improved airtransport. A study of airports at the grass roots
The feasibility of applying a particular conception of technology and social change to specific examples of technological development was investigated. The social and economic effects of improved airport capabilities on rural communities were examined. Factors which led to the successful implementation of a plan to construct sixty small airports in Ohio are explored and implications derived for forming public policies, evaluating air transportation development, and assessing technology
Superior diet for man in space Annual report, Oct. 1965 - Oct. 1966
Space flight liquid diets tested for stability and effect on intestinal flora of rat
Consciousness science : real progress and lingering misconceptions.
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Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the current study examined adoptive transfer of anti-Aβ antibodies to 19- and 23-month old APP-transgenic mice. METHODS: We investigated the effects of weekly anti-Aβ antibody treatment on radial-arm water-maze performance, parenchymal and vascular amyloid loads, and the presence of microhemorrhage in the brain. 19-month-old mice were treated for 1, 2 or 3 months while 23-month-old mice were treated for 5 months. Only the 23-month-old mice were subject to radial-arm water-maze testing. RESULTS: After 3 months of weekly injections, this passive immunization protocol completely reversed learning and memory deficits in these mice, a benefit that was undiminished after 5 months of treatment. Dramatic reductions of diffuse Aβ immunostaining and parenchymal Congophilic amyloid deposits were observed after five months, indicating that even well-established amyloid deposits are susceptible to immunotherapy. However, cerebral amyloid angiopathy increased substantially with immunotherapy, and some deposits were associated with microhemorrhage. Reanalysis of results collected from an earlier time-course study demonstrated that these increases in vascular deposits were dependent on the duration of immunotherapy. CONCLUSIONS: The cognitive benefits of passive immunotherapy persist in spite of the presence of vascular amyloid and small hemorrhages. These data suggest that clinical trials evaluating such treatments will require precautions to minimize potential adverse events associated with microhemorrhage
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