181 research outputs found
RMRP Is a Non-Coding RNA Essential for Early Murine Development
RMRP is a non-coding RNA that is ubiquitously expressed in both humans and mice. RMRP mutations that lead to decreased RMRP levels are found in the pleiotropic syndrome Cartilage Hair Hypoplasia. To assess the effects of deleting RMRP, we engineered a targeting vector that contains loxP sequences flanking RMRP and created hemizygous mice harboring this engineered allele (RMRP conditional). We found that insertion of this cassette suppressed RMRP expression, and we failed to obtain viable mice homozygous for the RMRP conditional allele. Furthermore, we were unable to obtain viable homozygous RMRP null mice, indicating that RMRP is essential for early embryonic development
Soliton Squeezing in a Mach-Zehnder Fiber Interferometer
A new scheme for generating amplitude squeezed light by means of soliton
self-phase modulation is experimentally demonstrated. By injecting 180-fs
pulses into an equivalent Mach-Zehnder fiber interferometer, a maximum noise
reduction of dB is obtained ( dB when corrected for
losses). The dependence of noise reduction on the interferometer splitting
ratio and fiber length is studied in detail.Comment: 5 pages, 4 figure
Superchemistry: dynamics of coupled atomic and molecular Bose-Einstein condensates
We analyze the dynamics of a dilute, trapped Bose-condensed atomic gas
coupled to a diatomic molecular Bose gas by coherent Raman transitions. This
system is shown to result in a new type of `superchemistry', in which giant
collective oscillations between the atomic and molecular gas can occur. The
phenomenon is caused by stimulated emission of bosonic atoms or molecules into
their condensate phases
A pulsed source of continuous variable polarization entanglement
We have experimentally demonstrated polarization entanglement using
continuous variables in an ultra-short pulsed laser system at telecommunication
wavelengths. Exploiting the Kerr-nonlinearity of a glass fibre we generated a
polarization squeezed pulse with S2 the only non-zero Stokes parameter thus S1
and S3 being the conjugate pair. Polarization entanglement was generated by
interference of the polarization squeezed field with a vacuum on a 50:50 beam
splitter. The two resultant beams exhibit strong quantum noise correlations in
S1 and S3. The sum noise signal of S3 was at the respective shot noise level
and the difference noise signal of S1 fell 2.9dB below this value
Multiple light scattering in anisotropic random media
In the last decade Diffusing Wave Spectroscopy (DWS) has emerged as a
powerful tool to study turbid media. In this article we develop the formalism
to describe light diffusion in general anisotropic turbid media. We give
explicit formulas to calculate the diffusion tensor and the dynamic absorption
coefficient, measured in DWS experiments. We apply our theory to uniaxial
systems, namely nematic liquid crystals, where light is scattered from thermal
fluctuations of the local optical axis, called director. We perform a detailed
analysis of the two essential diffusion constants, parallel and perpendicular
to the director, in terms of Frank elastic constants, dielectric anisotropy,
and applied magnetic field. We also point out the relevance of our results to
different liquid crystalline systems, such as discotic nematics, smectic-A
phases, and polymer liquid crystals. Finally, we show that the dynamic
absorption coefficient is the angular average over the inverse viscosity, which
governs the dynamics of director fluctuations.Comment: 23 pages, 12 ps figures, to be published in Phys. Rev.
Two Mode Quantum Systems: Invariant Classification of Squeezing Transformations and Squeezed States
A general analysis of squeezing transformations for two mode systems is given
based on the four dimensional real symplectic group Sp(4,\Re)\/. Within the
framework of the unitary metaplectic representation of this group, a
distinction between compact photon number conserving and noncompact photon
number nonconserving squeezing transformations is made. We exploit the
Sp(4,\Re)-SO(3,2)\/ local isomorphism and the U(2)\/ invariant squeezing
criterion to divide the set of all squeezing transformations into a two
parameter family of distinct equivalence classes with representative elements
chosen for each class. Familiar two mode squeezing transformations in the
literature are recognized in our framework and seen to form a set of measure
zero. Examples of squeezed coherent and thermal states are worked out. The need
to extend the heterodyne detection scheme to encompass all of U(2)\/ is
emphasized, and known experimental situations where all U(2)\/ elements can
be reproduced are briefly described.Comment: Revtex 37 pages, Latex figures include
Soliton back-action evading measurement using spectral filtering
We report on a back-action evading (BAE) measurement of the photon number of
fiber optical solitons operating in the quantum regime. We employ a novel
detection scheme based on spectral filtering of colliding optical solitons. The
measurements of the BAE criteria demonstrate significant quantum state
preparation and transfer of the input signal to the signal and probe outputs
exiting the apparatus, displaying the quantum-nondemolition (QND) behavior of
the experiment.Comment: 5 pages, 5 figure
Characterizing genomic alterations in cancer by complementary functional associations.
Systematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their interactions to drive or maintain oncogenic states, remains a challenge in cancer research. We developed REVEALER, a computational method that identifies combinations of mutually exclusive genomic alterations correlated with functional phenotypes, such as the activation or gene dependency of oncogenic pathways or sensitivity to a drug treatment. We used REVEALER to uncover complementary genomic alterations associated with the transcriptional activation of β-catenin and NRF2, MEK-inhibitor sensitivity, and KRAS dependency. REVEALER successfully identified both known and new associations, demonstrating the power of combining functional profiles with extensive characterization of genomic alterations in cancer genomes
RNF43 is frequently mutated in colorectal and endometrial cancers
We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.National Human Genome Research Institute (U.S.) (Grant U54HG003067
Quantum dynamics in ultra-cold atomic physics
We review recent developments in the theory of quantum dynamics in ultra-cold
atomic physics, including exact techniques, but focusing on methods based on
phase-space mappings that are appli- cable when the complexity becomes
exponentially large. These phase-space representations include the truncated
Wigner, positive-P and general Gaussian operator representations which can
treat both bosons and fermions. These phase-space methods include both
traditional approaches using a phase-space of classical dimension, and more
recent methods that use a non-classical phase-space of increased
dimensionality. Examples used include quantum EPR entanglement of a four-mode
BEC, time-reversal tests of dephasing in single-mode traps, BEC quantum
collisions with up to 106 modes and 105 interacting particles, quantum
interferometry in a multi-mode trap with nonlinear absorp- tion, and the theory
of quantum entropy in phase-space. We also treat the approach of variational
optimization of the sampling error, giving an elementary example of a nonlinear
oscillator
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