4 research outputs found

    Polímeros de frutose: importância para a nutrição e saúde humana

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    Inulin-type fructans are soluble nondigestible carbohydrates based on fructose found in many plants used in human nutrition. These polymers constituted by β-glycosidic bonds have prebiotic activity by selectively stimulating the multiplication and activity of beneficial intestinal bacteria. These microorganisms, as well as their metabolites resulting from the fermentation of fructans, have been associated to several positive effects on health and well-being such as intestinal function, immune response, metabolism, bone development, cognition and emotion in addition to preventing or improving many pathological conditions. Thus, this review aimed at raise the evidence on the effects of fructan supplementation on different aspects of human health. Therefore, it was surveyed randomized, double-blind, placebo-controlled clinical trials, published between 1995 and 2020 indexed in the databases Pubmed, Web of Science, Scielo, Scopus and Lilacs. Several studies demonstrated the benefits of fructans on many aspects of health and well-being, however, more clinical studies are necessary in order to improve the knowledge acquired until now and to fill gaps that still exist in available literature. This knowledge is essential to determine indications and possible contraindications in future therapeutic protocols.  : Frutanos do tipo inulina são carboidratos solúveis não digeríveis, à base de frutose, encontrados em muitos vegetais utilizados na alimentação humana. Esses polímeros constituídos por ligações β-glicosídicas apresentam atividade prebiótica, estimulando de forma seletiva a multiplicação e atividade de bactérias intestinais benéficas. Esses micro-organismos, bem como os seus metabólitos resultantes da fermentação dos frutanos, têm sido associados a diversos efeitos positivos sobre a saúde e bem-estar como função intestinal, resposta imune, metabolismo, desenvolvimento ósseo, cognição e emoção. Além disso, esses carboidratos apresentam potencial na prevenção e melhoria de diversas condições patológicas. Desta forma, a presente revisão teve como objetivo levantar as evidências sobre os efeitos da suplementação de frutanos em diversos aspectos da saúde humana. Para tal, foi realizado o levantamento de estudos clínicos randomizados, duplo cego, placebo controlados, publicados entre os anos de 1995 e 2020, indexados nas bases de dados Pubmed, Web of Science, Scielo, Scopus e Lilacs. Diversos trabalhos demonstraram os benefícios dos frutanos sobre muitos aspectos da saúde e bem-estar, no entanto, mais estudos clínicos ainda são necessários para ampliar o conhecimento adquirido até o momento e preencher lacunas importantes existentes sobre o tema. Este conhecimento é essencial para determinar indicações e eventuais contraindicações em futuros protocolos terapêuticos.

    Polímeros de frutose: importância para a nutrição e saúde humana

    No full text
    Inulin-type fructans are soluble nondigestible carbohydrates based on fructose found in many plants used in human nutrition. These polymers constituted by β-glycosidic bonds have prebiotic activity by selectively stimulating the multiplication and activity of beneficial intestinal bacteria. These microorganisms, as well as their metabolites resulting from the fermentation of fructans, have been associated to several positive effects on health and well-being such as intestinal function, immune response, metabolism, bone development, cognition and emotion in addition to preventing or improving many pathological conditions. Thus, this review aimed at raise the evidence on the effects of fructan supplementation on different aspects of human health. Therefore, it was surveyed randomized, double-blind, placebo-controlled clinical trials, published between 1995 and 2020 indexed in the databases Pubmed, Web of Science, Scielo, Scopus and Lilacs. Several studies demonstrated the benefits of fructans on many aspects of health and well-being, however, more clinical studies are necessary in order to improve the knowledge acquired until now and to fill gaps that still exist in available literature. This knowledge is essential to determine indications and possible contraindications in future therapeutic protocols.  : Frutanos do tipo inulina são carboidratos solúveis não digeríveis, à base de frutose, encontrados em muitos vegetais utilizados na alimentação humana. Esses polímeros constituídos por ligações β-glicosídicas apresentam atividade prebiótica, estimulando de forma seletiva a multiplicação e atividade de bactérias intestinais benéficas. Esses micro-organismos, bem como os seus metabólitos resultantes da fermentação dos frutanos, têm sido associados a diversos efeitos positivos sobre a saúde e bem-estar como função intestinal, resposta imune, metabolismo, desenvolvimento ósseo, cognição e emoção. Além disso, esses carboidratos apresentam potencial na prevenção e melhoria de diversas condições patológicas. Desta forma, a presente revisão teve como objetivo levantar as evidências sobre os efeitos da suplementação de frutanos em diversos aspectos da saúde humana. Para tal, foi realizado o levantamento de estudos clínicos randomizados, duplo cego, placebo controlados, publicados entre os anos de 1995 e 2020, indexados nas bases de dados Pubmed, Web of Science, Scielo, Scopus e Lilacs. Diversos trabalhos demonstraram os benefícios dos frutanos sobre muitos aspectos da saúde e bem-estar, no entanto, mais estudos clínicos ainda são necessários para ampliar o conhecimento adquirido até o momento e preencher lacunas importantes existentes sobre o tema. Este conhecimento é essencial para determinar indicações e eventuais contraindicações em futuros protocolos terapêuticos.

    Sugarcane bagasse as a source of carbon for enzyme production by filamentous fungi1

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    ABSTRACT The aim of the present work was to assess the enzymatic activity of six strains of filamentous fungi grown in liquid media containing 1% sugarcane bagasse as the sole carbon source. All fungal strains were able to use this agro-industrial residue, producing various types of enzymes, such as cellulases, xylanases, amylases, pectinases, and laccases. However, Aspergillus japonicus Saito was the most efficient producer, showing the highest enzymatic activity for laccase (395.73 U L-1), endo-β-1,4-xylanase (3.55 U mL-1) and β-xylosidase (9.74 U mL-1) at seven, fourteen and twenty-one days in culture, respectively. Furthermore, the endo-β-1,4-xylanases and β-xylosidases of A. japonicus showed maximum activity at 50°C, and pH 5.5 and pH 3.5-4.5, respectively. Thus, these results indicate that A. japonicus has a great biotechnological potential for the production of these enzymes using sugarcane bagasse as the sole source of carbon

    Sugarcane bagasse as a source of carbon for enzyme production by filamentous fungi1

    No full text
    <div><p>ABSTRACT The aim of the present work was to assess the enzymatic activity of six strains of filamentous fungi grown in liquid media containing 1% sugarcane bagasse as the sole carbon source. All fungal strains were able to use this agro-industrial residue, producing various types of enzymes, such as cellulases, xylanases, amylases, pectinases, and laccases. However, Aspergillus japonicus Saito was the most efficient producer, showing the highest enzymatic activity for laccase (395.73 U L-1), endo-β-1,4-xylanase (3.55 U mL-1) and β-xylosidase (9.74 U mL-1) at seven, fourteen and twenty-one days in culture, respectively. Furthermore, the endo-β-1,4-xylanases and β-xylosidases of A. japonicus showed maximum activity at 50°C, and pH 5.5 and pH 3.5-4.5, respectively. Thus, these results indicate that A. japonicus has a great biotechnological potential for the production of these enzymes using sugarcane bagasse as the sole source of carbon.</p></div
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