A study of the effectiveness of a phonetic and activity approach to the teaching of spelling in grade four,

Includes appendices. Thesis (M.A.)--Boston Universit

Multi-point Assessment of the Kinematics of Shocks (MAKOS): A Heliophysics Mission Concept Study

Collisionless shocks are fundamental processes that are ubiquitous in space plasma physics throughout the Heliosphere and most astrophysical environments. Earth's bow shock and interplanetary shocks at 1 AU offer the most readily accessible opportunities to advance our understanding of the nature of collisionless shocks via fully-instrumented, in situ observations. One major outstanding question pertains to the energy budget of collisionless shocks, particularly how exactly collisionless shocks convert incident kinetic bulk flow energy into thermalization (heating), suprathermal particle acceleration, and a variety of plasma waves, including nonlinear structures. Furthermore, it remains unknown how those energy conversion processes change for different shock orientations (e.g., quasi-parallel vs. quasi-perpendicular) and driving conditions (upstream Alfv\'enic and fast Mach numbers, plasma beta, etc.). Required to address these questions are multipoint observations enabling direct measurement of the necessary plasmas, energetic particles, and electric and magnetic fields and waves, all simultaneously from upstream, downstream, and at the shock transition layer with observatory separations at ion to magnetohydrodynamic (MHD) scales. Such a configuration of spacecraft with specifically-designed instruments has never been available, and this white paper describes a conceptual mission design -- MAKOS -- to address these outstanding questions and advance our knowledge of the nature of collisionless shocks.Comment: White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 9 pages, 3 figures, 5 table

Study protocol: home-based telehealth stroke care: a randomized trial for veterans

<p>Abstract</p> <p>Background</p> <p>Stroke is one of the most disabling and costly impairments of adulthood in the United States. Stroke patients clearly benefit from intensive inpatient care, but due to the high cost, there is considerable interest in implementing interventions to reduce hospital lengths of stay. Early discharge rehabilitation programs require coordinated, well-organized home-based rehabilitation, yet lack of sufficient information about the home setting impedes successful rehabilitation. This trial examines a multifaceted telerehabilitation (TR) intervention that uses telehealth technology to simultaneously evaluate the home environment, assess the patient's mobility skills, initiate rehabilitative treatment, prescribe exercises tailored for stroke patients and provide periodic goal oriented reassessment, feedback and encouragement.</p> <p>Methods</p> <p>We describe an ongoing Phase II, 2-arm, 3-site randomized controlled trial (RCT) that determines primarily the effect of TR on physical function and secondarily the effect on disability, falls-related self-efficacy, and patient satisfaction. Fifty participants with a diagnosis of ischemic or hemorrhagic stroke will be randomly assigned to one of two groups: (a) TR; or (b) Usual Care. The TR intervention uses a combination of three videotaped visits and five telephone calls, an in-home messaging device, and additional telephonic contact as needed over a 3-month study period, to provide a progressive rehabilitative intervention with a treatment goal of safe functional mobility of the individual within an accessible home environment. Dependent variables will be measured at baseline, 3-, and 6-months and analyzed with a linear mixed-effects model across all time points.</p> <p>Discussion</p> <p>For patients recovering from stroke, the use of TR to provide home assessments and follow-up training in prescribed equipment has the potential to effectively supplement existing home health services, assist transition to home and increase efficiency. This may be particularly relevant when patients live in remote locations, as is the case for many veterans.</p> <p>Trial Registration</p> <p>Clinical Trials.gov Identifier: NCT00384748</p

The Distribution, Metabolism, and Elimination of Clofarabine in Rats

Abstract The distribution, metabolism and elimination of intravenous 14C-clofarabine was studied in Fischer 344 male rats under a once daily for 5 days dosing schedule of 25 or 50 mg/kg/day. Also, the in vitro metabolism in rat, dog, and human hepatocytes was studied. Plasma radioactivity (of which clofarabine accounted for 63% to 93%) exhibited three phases of exponential elimination with half-lives of 0.3, 1.3, and 12.8 hours after administration of the 25 mg/kg/d regimen. Unscheduled deaths occurred after 1 to 3 doses with the 50 mg/kg regimen, possibly due to nonlinear pharmacokinetics, and so mass balance and radiokinetic profiles could not be obtained. A total of 77.1% (of which 87.2% was clofarabine) and 10.8% (of which 6.9% was clofarabine) of the dose was recovered in urine and feces, respectively. 6-ketoclofarabine, believed to be formed via adenosine deaminase, was the metabolite of greatest concentration found in urine and feces, but in each matrix accounted for only 7% of the daily recovery of radioactivity. 6-ketoclofarabine was also found in myocardium and liver, but accounted for less than 2% of the total radioactivity in those tissues. Clofarabine was the major analyte found in myocardium (&gt; 97% region of integration) and liver (&gt; 94% region of integration). Whole body autoradiography demonstrated that the highest postdistributive concentrations of radioactivity were in the excretory organs, kidney, bladder and GI tract, with no remarkable suborgan distribution. In rat, dog, and human hepatocytes, 95, 96, and 99.8%14C-clofarabine remained, respectively, after 6 hours incubation. Eleven metabolites were observed with the largest constituting 2.5% of the radioactivity

The Victorian Newsletter (Fall 1970)

The Victorian Newsletter is edited for the English X Group of the Modern Language Association by William E. Buckler, New York University, New York, N.Y. 10003.Dickens' Portrait of the Artist / Edward Hurley -- Black and White Characters in Hard Times / Mary Rose Sullivan -- "All Her Perfections Tarnished": The Thematic Function of Esther Summerson / Mary Daehler Smith -- Another Look at Hardy's "Afterwards" / David S. Thatcher -- Meredith's Experiments with Ideas / J. Raban Bilder -- Huxley, Holmes, and the Scientist as Aesthete / Phyllis Rose -- Tory Noodles in Sydney Smith and Charles Dickens: An Unnoticed Parallel / Robert Simpson McLean -- Stanza Form in Meredith's Modern Love / Willie D. Reader -- Recent Publications: A Selected List / Arthur F. Minerof -- English X New

The Persistent Mystery of Collisionless Shocks

Collisionless shock waves are one of the main forms of energy conversion in space plasmas. They can directly or indirectly drive other universal plasma processes such as magnetic reconnection, turbulence, particle acceleration and wave phenomena. Collisionless shocks employ a myriad of kinetic plasma mechanisms to convert the kinetic energy of supersonic flows in space to other forms of energy (e.g., thermal plasma, energetic particles, or Poynting flux) in order for the flow to pass an immovable obstacle. The partitioning of energy downstream of collisionless shocks is not well understood, nor are the processes which perform energy conversion. While we, as the heliophysics community, have collected an abundance of observations of the terrestrial bow shock, instrument and mission-level limitations have made it impossible to quantify this partition, to establish the physics within the shock layer responsible for it, and to understand its dependence on upstream conditions. This paper stresses the need for the first ever spacecraft mission specifically designed and dedicated to the observation of both the terrestrial bow shock as well as Interplanetary shocks in the solar wind.Comment: White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 9 pages, 4 figure

On the biomedicalization of alcoholism

The shift in the prevailing view of alcoholism from a moral paradigm towards a biomedical paradigm is often characterized as a form of biomedicalization. We will examine and critique three reasons offered for the claim that viewing alcoholism as a disease is morally problematic. The first is that the new conceptualization of alcoholism as a chronic brain disease will lead to individualization, e.g., a too narrow focus on the individual person, excluding cultural and social dimensions of alcoholism. The second claim is that biomedicalization will lead to stigmatization and discrimination for both alcoholics and people who are at risk of becoming alcoholics. The third claim is that as a result of the biomedical point of view, the autonomy and responsibility of alcoholics and possibly even persons at risk may be unjustly restricted. Our conclusion is that the claims against the biomedical conceptualization of alcoholism as a chronic brain disease are neither specific nor convincing. Not only do some of these concerns also apply to the traditional moral model; above that they are not strong enough to justify the rejection of the new biomedical model altogether. The focus in the scientific and public debate should not be on some massive “biomedicalization objection” but on the various concerns underlying what is framed in terms of the biomedicalization of alcoholism

Supported housing programs for persons with serious mental illness in rural northern communities: A mixed method evaluation

Background: During the past two decades, consumers, providers and policy makers have recognized the role of supported housing intervention for persons diagnosed with serious mental illness (SMI) to be able to live independently in the community. Much of supported housing research to date, however, has been conducted in large urban centers rather than northern and rural communities. Northern conditional and contextual issues such as rural poverty, lack of accessible mental health services, small or non-existing housing markets, lack of a continuum of support or housing services, and in some communities, a poor quality of housing challenge the viability of effective supported housing services. The current research proposal aims to describe and evaluate the processes and outcomes of supported housing programs for persons living with SMI in northern and rural communities from the perspective of clients, their families, and community providers. Methods: This research will use a mixed method design guided by participatory action research. The study will be conducted over two years, in four stages. Stage I will involve setting up the research in each of the four northern sites. In Stage II a descriptive cross-sectional survey will be used to obtain information about the three client outcomes: housing history, quality of life and housing preference. In Stage III two participatory action strategies, focus groups and photo-voice, will be used to explore perceptions of supported housing services. In the last stage findings from the study will be re-presented to the participants, as well as other key community individuals in order to translate them into policy. Conclusion: Supported housing intervention is a core feature of mental health care, and it requires evaluation. The lack of research in northern and rural SMI populations heightens the relevance of research findings for health service planning. The inclusion of multiple stakeholder groups, using a variety of data collection approaches, contributes to a comprehensive, systems-level examination of supported housing in smaller communities. It is anticipated that the study\u27s findings will not only have utility across Ontario, but also Canada