Experiences with the Greenstone digital library software for international development

Greenstone is a versatile open source multilingual digital library environment, emerging from research on text compression within the New Zealand Digital Library Research Project in the Department of Computer Science at the University of Waikato. In 1997 we began to work with Human Info NGO to help them produce fully-searchable CD-ROM collections of humanitarian information. The software has since evolved to support a variety of application contexts. Rather than being simply a delivery mechanism, we have emphasised the empowerment of users to create and distribute their own digital collections

Effective engagement of conservation scientists with decision-makers

This chapter offers advice on how the conservation science community can effectively engage with decision-makers. The rationales for why we, as scientists, need to do this have been widely discussed in the literature. Often, the reasons offered are normative, pragmatic, or instrumental (de Vente, 2016); in other words, there is a belief that engaging with decision-makers leads to better informed, more acceptable decisions. Indeed, better engagement may lead to the greater uptake of evidence for conservation decisions, something which some scholars argue is a priority for effective management (e.g. Gardner et al., 2018; Sutherland and Wordley, 2017)

Estimating particle sizes, concentrations, and total mass of ash in volcanic clouds using weather radar

Observations of the March 19, 1982 ash eruption of Mount St. Helens, made by the National Weather Service (NWS, Portland, Oregon) on 5-cm radar, were used to estimate the volume of the ash cloud (2000 ±500 km3), the concentration of ash (0.2–0.6 g m−3). and the total mass of ash erupted (3–10×1011 g). The position of the cloud was also tracked by radar. Particle sizes in the ash cloud were estimated from settling velocities suggested by decreases in maximum ash cloud height with time as it moved away from the volcano. The March 19, 1982 ash blanket was sampled and mapped. Ash fallout times and accumulation rates were reconstructed from ground observations. Grain size distributions for various samples were used to obtain particle concentration (0.2 g m−3), total ashfall mass (1–3×1011 g), and radar reflectivity factor (4–5 mm6 m−3) for the ash cloud. Our preferred estimate for total ashfall mass (4×1011 g) is that obtained from the product of the ash cloud volume determined by radar (2000±500 km3) and the particle concentration inferred from ashfall data (0.2 g m−3). Previously published ashfall data for the May 18, 1980 Mount St. Helens eruption has been studied using our ashfall inversion technique to estimate 6-hour mean particle concentration (3 g m−3), the size distribution, total ashfall mass (5×1014 g), and radar reflectivity factors (7–60 mm6 m−3) for the ash cloud. A somewhat higher value (9 g m−3) for particle concentration was estimated from radar observations [Harris et al., 1981] for an ash cloud formed during the peak eruption rate at Mount St. Helens. The two independent estimates are consistent, given the many uncertainties of the problem. The reflectivity factors for very dense ash clouds (3–9 g m−3) are several orders of magnitude smaller than for severe weather considered routinely detectable by airborne weather radar and dangerous for aviation. Because volcanic ash clouds with particle concentrations of at least 0.2 g m−3 are produced in extremely small eruptions (in terms of total ashfall mass) of duration less than 1 minute, volcanic ash clouds must be considered an extremely serious hazard to in-flight aircraft, regardless of eruption magnitude. These factors should be considered in hazard evaluations for known volcanoes located near air routes. Radar observations and calculations can provide scientists monitoring eruptive activity with significant information for estimating duration of eruption, particle concentrations in ash clouds, total mass of solid material erupted, magma eruption rate, potential ashfall mass, ashfall locations and accumulation rates, and duration and amounts of ashfall. Detailed analysis of ashfall data and NWS radar observations of ash clouds from Mount St. Helens demonstrate that weather radar can yield such timely information during and following volcanic eruptions

Demand for taxi services: New elasticity evidence for a neglected mode

This paper investigates the factors that influence the choice of, and hence demand for taxis services, a relatively neglected mode in the urban travel task. Given the importance of positioning preferences for taxi services within the broader set of modal options, we develop a modal choice model for all available modes of transport for trips undertaken by individuals or groups of individuals in a number of market segments. A sample of recent trips in Melbourne in 2012 was used to develop segmentspecific mode choice models to obtain direct (and cross) elasticities of interest for cost and service level attributes. Given the nonlinear functional form of the way attributes of interest are included in the modal choice models, a simple set of mean elasticity estimates are not behaviourally meaningful; hence a decision support system is developed to enable the calculation of mean elasticity estimates under specific future service and pricing levels. Some specific direct elasticity estimates are provided as the basis of illustrating the magnitudes of elasticity estimates under likely policy settings

Carbon-13 in groundwater from English and Norwegian crystalline rock aquifers: a tool for deducing the origin of alkalinity?

The 13C signature is evaluated for various environmental compartments (vegetation, soils, soil gas, rock and groundwater) for three crystalline rock terrains in England and Norway. The data are used to evaluate the extent to which stable carbon isotopic data can be applied to deduce whether the alkalinity in crystalline bedrock groundwaters has its origin in hydrolysis of carbonate or silicate minerals by CO2. The resolution of this issue has profound implications for the role of weathering of crystalline rocks as a global sink for CO2. In the investigated English terrain (Isles of Scilly), groundwaters are hydrochemically immature and DIC is predominantly in the form of carbonic acid with a soil gas signature. In the Norwegian terrains, the evidence is not conclusive but is consistent with a significant fraction of the groundwater DIC being derived from silicate hydrolysis by CO2. A combined consideration of pH, alkalinity and carbon isotope data, plotted alongside theoretical evolutionary pathways on bivariate diagrams, strongly suggests real evolutionary pathways are likely to be hybrid, potentially involving both open and closed CO2 conditions

Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty.

PurposeMatrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and fibrosis. We assessed MMP protein expression levels in diseased corneas of patients requiring penetrating and deep anterior lamellar keratoplasty. The purpose of this study was to test the hypothesis that upregulation of MMPs in diseased corneas is positively associated with clinical levels of corneal neovascularization and fibrosis.MethodsProtein expression levels of nine individual MMPs were quantified simultaneously in human corneal lysates by using the Bio-Plex Pro Human MMP 9-Plex Panel and the MAGPIX technology. Measurements of MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP12, and MMP13 were performed on diseased specimens from 21 patients undergoing corneal transplantation (17 for penetrating keratoplasty and 4 for deep anterior lamellar keratoplasty) and 6 normal control corneas.ResultsLuminex-based expression analysis revealed a significant overexpression of four of the nine MMPs tested (MMP2, MMP8, MMP12, and MMP13) in patient samples compared to control. Significant overexpression of MMP1, MMP2, MMP8, MMP12, and MMP13 was observed in diseased corneas with neovascularization compared with diseased corneas without neovascularization. Overexpression of MMP1, MMP2, MMP8, MMP12, and MMP13 also corresponded with the levels of corneal fibrosis. Finally, reduced expression of MMP3 was detected in keratoconus patients.ConclusionsMultiple MMPs are expressed in the corneas of patients with chronic disease requiring keratoplasty even when the pathologic process appears to be clinically inactive. In particular, the expression of several MMPs (MMP2, MMP8, MMP12, and MMP13) is positively associated with increased levels corneal fibrosis and neovascularization

Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model

Neurofibrillary tangles are a feature of Alzheimer disease and other tauopathies, and while they are generally believed to be markers of neuronal pathology, there is little evidence evaluating whether tangles directly impact neuronal function. To investigate the response of cells in hippocampal circuits to complex behavioral stimuli, we used an environmental enrichment paradigm to induce expression of an immediate-early gene, Arc, in the rTg4510 mouse model of tauopathy. These mice reversibly overexpress P301L tau and exhibit substantial neurofibrillary tangle deposition, neuronal loss, and memory deficits. Employing fluorescent in situ hybridization to detect Arc mRNA, we found that rTg4510 mice have impaired hippocampal Arc expression both without stimulation and in response to environmental enrichment; this likely reflects the combination of functional impairments of existing neurons and loss of neurons. However, tangle-bearing cells were at least as likely as non-tangle-bearing neurons to exhibit Arc expression in response to enrichment. Transgene suppression with doxycycline for 6 weeks resulted in increased percentages of Arc-positive cells in rTg4510 brains compared to untreated transgenics, restoring enrichment-induced Arc mRNA levels to that of wild-type controls despite the continued presence of neurofibrillary pathology. We interpret these data to indicate that soluble tau contributes to impairment of hippocampal function, while tangles do not preclude neurons from responding in a functional circuit

Extending stated choice analysis to recognise agentspecific attribute endogeneity in bilateral group negotiation and choice: A think piece

This paper is a think piece on variations in the structure of stated preference studies when modelling the joint preferences of interacting agents who have the power to influence the attribute levels on offer. The approach proposed is an extension of standard stated choice methods. Known as ‘stated endogenous attribute level’ (SEAL) analysis, it allows for interactive agents to adjust attribute levels off a base stated choice specification that are within their control, in an effort to reach agreement in an experimental setting. This accomplishes three goals: (1) the ability to place respondents in an environment that more closely matches interactive settings in which some attribute levels are endogenous to a specific agent, should the modeller wish to capture such behaviour; (2) the improved ability of the modeller to capture the behaviour in such settings, including a greater wealth of information on the related interaction processes, rather than simply outcomes; and (3) the expansion of the set of situations that the modeller can investigate using experimental data

Duplication and analysis of meteoroid damage on LDEF and advanced spacecraft materials

The analysis of exposed surfaces on LDEF since its retrieval in 1990 has revealed a wide range of meteoroid and debris (M&D) impact features in the sub-micron to millimeter size range, ranging from quasi-infinite target cratering in LDEF metallic structural members (e.g. inter-costals, tray clamps, etc.) to non-marginal perforations in metallic experimental surfaces (e.g. thin foil detectors, etc.). Approximately 34,000 impact features are estimated to exist on the exposed surfaces of LDEF. The vast majority of impact craters in metal substrates exhibit circular footprints, with approximately 50 percent retaining impactor residues in varying states of shock processing. The fundamental goals of this project were to duplicate and analyze meteoroid impact damage on spacecraft metallic materials with a view to quantifying the residue retention and oblique impact morphology characteristics. Using the hypervelocity impact test facility established at Auburn University a series of impact tests (normal and oblique incidence) were executed producing consistently high (11-12 km/s) peak impact velocities, the results of which were subsequently analyzed using Scanning Electron Microscope (SEM) and Energy Dispersive X-ray Spectroscopy (EDXS) facilities at Auburn University