X-ray observations of the Large Magellanic Cloud pulsar PSR B0540-69 and its PWN

PSR B0540-69 is a young pulsar in the Large Magellanic Cloud that has similar properties with respect to the Crab Pulsar, and is embedded in a Pulsar Wind Nebula. We have analyzed the complete archival RXTE dataset of observations of this source, together with new Swift-XRT and INTEGRAL-IBIS data. Accurate lightcurves are produced in various energy bands between 2 and 60 keV, showing no significant energy variations of the pulse shape. The spectral analysis shows that the pulsed spectrum is curved, and is best fitted up to 100 keV by a log-parabolic model: this strengthens the similarities with the Crab pulsar, and is discussed in the light of a phenomenologic multicomponent model. The total emission from this source is studied, the relative contributions of the pulsar and the PWN emission are derived, and discussed in the context of other INTEGRAL detected pulsar/PWN systems.Comment: 11 pages, 11 figures. Accepted for publication in MNRA

Identifying pathways modulating sleep duration: from genomics to transcriptomics

Recognizing that insights into the modulation of sleep duration can emerge by exploring the functional relationships among genes, we used this strategy to explore the genome-wide association results for this trait. We detected two major signalling pathways (ion channels and the ERBB signalling family of tyrosine kinases) that could be replicated across independent GWA studies meta-analyses. To investigate the significance of these pathways for sleep modulation, we performed transcriptome analyses of short sleeping flies' heads (knockdown for the ABCC9 gene homolog;dSur). We found significant alterations in gene-expression in the short sleeping knockdowns versus controls flies, which correspond to pathways associated with sleep duration in our human studies. Most notably, the expression of Rho and EGFR (members of the ERBB signalling pathway) genes was down-and up-regulated, respectively, consistently with the established role of these genes for sleep consolidation in Drosophila. Using a disease multifactorial interaction network, we showed that many of the genes of the pathways indicated to be relevant for sleep duration had functional evidence of their involvement with sleep regulation, circadian rhythms, insulin secretion, gluconeogenesis and lipogenesis

Identifying pathways modulating sleep duration : from genomics to transcriptomics

Recognizing that insights into the modulation of sleep duration can emerge by exploring the functional relationships among genes, we used this strategy to explore the genome-wide association results for this trait. We detected two major signalling pathways (ion channels and the ERBB signalling family of tyrosine kinases) that could be replicated across independent GWA studies meta-analyses. To investigate the significance of these pathways for sleep modulation, we performed transcriptome analyses of short sleeping flies’ heads (knockdown for the ABCC9 gene homolog; dSur). We found significant alterations in gene-expression in the short sleeping knockdowns versus controls flies, which correspond to pathways associated with sleep duration in our human studies. Most notably, the expression of Rho and EGFR (members of the ERBB signalling pathway) genes was down- and upregulated, respectively, consistently with the established role of these genes for sleep consolidation in Drosophila. Using a disease multifactorial interaction network, we showed that many of the genes of the pathways indicated to be relevant for sleep duration had functional evidence of their involvement with sleep regulation, circadian rhythms, insulin secretion, gluconeogenesis and lipogenesis

A new technique for probing the internal structure of volcanoes using cosmic-ray muons

Among the considerable number of studies that can be carried out using muons, we pay specific attention to the radiography of volcanoes based on the same principle of the X-ray radiography of human body. Thanks to their high penetration capability, cosmic-ray muons can be used to reconstruct the density distribution of the interior of huge structures by measuring the attenuation induced by the material on the muon flux. In particular, the quantitative understanding of the inner structure of volcanoes is a key-point to forecast the dangerous stages of activity and mitigate volcanic hazards. The instrumental approach is currently based on the detection of muons crossing hodoscopes made up of scintillator planes. Unfortunately, these detectors are affected by a strong background comprised by accidental coincidence of vertical shower particles, horizontal high-energy electrons and upward going particles. We propose an alternative technique based on the detection of the Cherenkov light produced by muons. This can be achieved with an imaging atmospheric Cherenkov telescope composed of a high reflectivity optical system that focus the Cherenkov light onto a multi-pixel focal camera with fast read-out electronics. The Cherenkov light emitted by a muon is imaged on the camera as an annular pattern which contains information to reconstruct the direction of the incident muon. We have estimated that using the Cherenkov imaging technique for muon radiography of volcanoes gives the advantage of a negligible background and improved spatial resolution, compared to the majority of the particle detectors. We present results of simulations based on a telescope with a positioning resolution of 13.5 m which corresponds to an acceptance of 9 cm2 sr. The telescope is located 1500 m far from a toy-model volcano, namely, a cone with a base diameter of 500 m and a height of 240 m. We test the feasibility of the proposed method by estimating the minimum number of observation nights needed to resolve inner empty conduits of different diameter.Published122–1252V. Struttura e sistema di alimentazione dei vulcaniN/A or not JC

Final performances of the X-ray Mirrors of the JET-X telescope

The Joint European Telesscope (JET-X) is one of the core scientific instruments of the SPECTRUM-X-Gamma mission. JET-X was designed to study X-ray emissions in the band 0.3-10 KeV. Its angular resolution is better than 20 arcsec; the values of the effective areas are 161 cm2 at 1.5 KeV and 69 cm2 at 8 Kev (for one telescope). The value of the HEW circle in function of the off-axis angle is presented; it is found to be below 20 arcsec at 1.5 Kev and around 23 arcsec at 8 KeV up to an off-axis angle of 12 arcmin.Comment: 2 pages, 1 ps figure. To be published in the Proceedings of the IAU Symposium 188 THE HOT UNIVERSE, held in Kyoto (August 26-30, 1997) in occasion of the XXIII IAU General Assembl

Looking inside volcanoes with the Imaging Atmospheric Cherenkov Telescopes

Cherenkov light is emitted when charged particles travel through a dielectric medium with velocity higher than the speed of light in the medium. The ground-based Imaging Atmospheric Cherenkov Telescopes (IACT), dedicated to the very-high energy γ-ray Astrophysics, are based on the detection of the Cherenkov light produced by relativistic charged particles in a shower induced by TeV photons interacting with the Earth atmosphere. Usually, an IACT consists of a large segmented mirror which reflects the Cherenkov light onto an array of sensors, placed at the focal plane, equipped by fast electronics. Cherenkov light from muons is imaged by an IACT as a ring, when muon hits the mirror, or as an arc when the impact point is outside the mirror. The Cherenkov ring pattern contains information necessary to assess both direction and energy of the incident muon. Taking advantage of the muon detection capability of IACTs, we present a new application of the Cherenkov technique that can be used to perform the muon radiography of volcanoes. The quantitative understanding of the inner structure of a volcano is a key-point to monitor the stages of the volcano activity, to forecast the next eruptive style and, eventually, to mitigate volcanic hazards. Muon radiography shares the same principle as X-ray radiography: muons are attenuated by higher density regions inside the target so that, by measuring the differential attenuation of the muon flux along different directions, it is possible to determine the density distribution of the interior of a volcano. To date, muon imaging of volcanic structures has been mainly achieved with detectors made up of scintillator planes. The advantage of using Cherenkov telescopes is that they are negligibly affected by background noise and allow a consistently improved spatial resolution when compared to the majority of the current detectors.Published111-1142V. Struttura e sistema di alimentazione dei vulcaniJCR Journa

Apparatus and method for non-invasive inspection of solid bodies by muon imaging

The present invention has application in the technical field of measuring instruments and it relates to an apparatus for non-invasive inspection of solid bodies by muon imaging usable in civil engineering, archeology, volcanology, tectonics and everywhere a radiographic and/or tomographic non-destructive inspection of geological and/or engineering structures, even of large dimensions, is necessary The invention further relates to a method for non-invasive inspection by muon imaging implementable by said apparatus

Muon imaging of volcanoes with Cherenkov telescopes

The quantitative understanding of the inner structure of a volcano is a key feature to model the processes leading to paroxysmal activity and, hence, to mitigate volcanic hazards. To pursue this aim, different geophysical techniques are utilized, that are sensitive to different properties of the rocks (elastic, electrical, density). In most cases, these techniques do not allow to achieve the spatial resolution needed to characterize the shallowest part of the plumbing system and may require dense measurements in active zones, implying a high level of risk. Volcano imaging through cosmic-ray muons is a promising technique that allows to overcome the above shortcomings. Muons constantly bombard the Earth's surface and can travel through large thicknesses of rock, with an energy loss depending on the amount of crossed matter. By measuring the absorption of muons through a solid body, one can deduce the density distribution inside the target. To date, muon imaging of volcanic structures has been mainly achieved with scintillation detectors. They are sensitive to noise sourced from (i) the accidental coincidence of vertical EM shower particles, (ii) the fake tracks initiated from horizontal high-energy electrons and low-energy muons (not crossing the target) and (iii) the flux of upward going muons. A possible alternative to scintillation detectors is given by Cherenkov telescopes. They exploit the Cherenkov light emitted when charged particles (like muons) travel through a dielectric medium, with velocity higher than the speed of light. Cherenkov detectors are not significantly affected by the above noise sources. Furthermore, contrarily to scintillator-based detectors, Cherenkov telescopes permit a measurement of the energy spectrum of the incident muon flux at the installation site, an issue that is indeed relevant for deducing the density distribution inside the target. In 2014, a prototype Cherenkov telescope was installed at the Astrophysical Observatory of Serra La Nave (southern flank of Mt. Etna, Italy; 1740m a.s.l.), in the framework of ASTRI, a flagship project of the Italian Ministry of Education, University and Research, led by the Italian National Institute of Astrophysics (INAF). This offers the opportunity to test the use of a Cherenkov telescope for imaging volcanic structures. Starting from this know-how, we plan to develop a new prototype of Cherenkov detector with suitable characteristics for installation in the summit zone of Etna volcano (around 3000m a.s.l.)