Unbounding entrepreneurial intents of university students: a multidisciplinary perspective

Entrepreneurial activities are seen as key drivers of innovation, job creation, and economic growth. Recent efforts are being pursued by several entities, including governments to promote entrepreneurial skills amongst the youngest. However, to design effective programs, policy makers have to uncover the determinants of entrepreneurship. To avoid that such efforts would be fruitless we argue that a multidisciplinary account of entrepreneurial intents among students is mandatory, circumventing past biased analysis towards business and engineering areas. Thus, in this paper we present the results of a survey to all final year university students of the largest Portuguese university. It encompasses a sample of 2431 students enrolled in 60 different undergraduate courses of 14 schools/faculties. Results evidence that the average entrepreneurial intents reaches a reasonable (by international standards) figure of 27%, with students enrolled in non-traditionally entrepreneurial focused areas – Humanities, Sports, Health and Sciences – and courses - Pharmacy, Veterinary, Law, Languages, History, History of the Arts and Archaeology, Sports, Biology and Chemistry, Dentistry - revealing higher entrepreneurial intents. Based on logit estimations, we further found that psychological factors, such as risk propensity, leadership profile, and creativeness, are the most important (positive) determinants of students’ entrepreneurial intents. Contextual factors (e.g., family background and professional experience) failed to emerge as critical factors in explaining students’ entrepreneurial intents - only business context emerged as important. Despite such results might at a first glance convey the idea that education policy for promoting entrepreneurship has limited application, we argue that it is not the case. What is required is different policy measures targeting students’ attitudes and behaviors in both business and non business areas, avoiding the long-established mistake of confining entrepreneurial education related programs within business schools.Entrepreneurship; Intents; Students; Higher Education; Multidisciplinary; Portugal

Invertebrados Associados A Bromélias Em Fragmentos De Mata Atlântica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Forest fragments in the state of Minas Gerais contain a large number of Bromeliaceae genera, whose cisterns accumulate water and organic matter, providing shelter and food for a wide range of organisms. However, these fragments often consist only of small patches of vegetation, making the species more vulnerable to the effects of this landscape changes. This study aimed to test the effect of the distance to the edge and of the matrix type on the structure of aquatic invertebrate communities in four morphospecies of bromeliads. Samples were collected in Atlantic Forest fragments adjacent to pasture and planted forest areas, in a region of Serra da Mantiqueira, Brazil. Of the 147 bromeliads investigated, we found 35 taxa, among which the most abundant groups were Ostracoda (4,962 individuals), Culicidae (2,358), Tanypodinae (1,164) and Scirtidae (1,043). The richness of taxa and Shannon diversity of invertebrates were similar at different distances from the edge, with variation of richness between 17 and 23 taxa and diversity between 1.25 and 1.52. The composition of the fauna in the cisterns changed between some collection sections (A vs. C, C vs. D and D vs. F), irrespective of being close to or far from the edge. There was no variation of richness (t=-1.145, df=106, p= 0.341) and diversity (t= 1.376, df= 106, p= 0.429) among samples collected from fragments next to planted forest and pasture, likely because the bromeliads studied were located on hillsides above the canopy of planted forests, and subject to similar conditions to those found in the fragments next to pastures. The results demonstrate the importance of bromeliads in maintaining the richness and diversity of the invertebrates they harbor, even in altered landscapes exposed to extreme conditions such as fragment edges. © 2017, Universidade Estadual de Campinas UNICAMP. All rights reserved.171CAPES, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior303156/2012-0, CNPq, Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG, Fundação de Amparo à Pesquisa do Estado de Minas GeraisCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Histamine in diabetes: is it time to reconsider?

The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an increase in plasma and leucocyte histamine content was observed. Limited independent evidence followed in the subsequent two decades, focusing on both histamine glyceamic control and macro- and microvascular complications of diabetes. However, recent observations have sparked the question whether it is time to reconsider the functional contribution of histamine in diabetes. We reveal an interesting upsurge in the field which provides scope for new insights into the role of histamine in diabetes

Co-gasification of glycerol/fat mixtures in a downflow fixed bed reactor: Preliminary results

The aim of this work was to assess the technical viability of glycerol/fat co-gasification. The gasification performance was studied in a downflow fixed bed reactor using steam as oxidizing agent. Tests were performed with a mixture of 10% of fat and 52% of water, and the effect of temperature was evaluated in the 800 oC to 950 oC range. Samples of dry gas from the gasifier were collected and analysed by gas chromatography in order to determine the CO, CO2, CH4 and H2 content. The results revealed that the co-gasification of glycerol/fat mixtures seems to be a feasible technical option. Best results of the gasification parameters were obtained at the highest tested temperature, 950 ◦C.This work was supported by Portugal 2020 [POCI-01-0145-FEDER-024067] and Fundação para a Ciência e Tecnologia [SFRH/BD/137913/2018].info:eu-repo/semantics/publishedVersio

Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning

How developing vascular networks acquire the right balance of arteries, veins and lymphatic vessels to efficiently supply and drain tissues is poorly understood. In zebrafish embryos, the robust and regular 50:50 global balance of intersegmental veins and arteries that form along the trunk, prompts the intriguing question how the organism keeps "count". Previous studies suggest that the ultimate fate of an intersegmental vessel (ISV) is determined by the identity of the approaching secondary sprout emerging from the posterior cardinal vein (PCV). Here, we show that the formation of a balanced trunk vasculature involves an early heterogeneity in endothelial cell (EC) behavior and Notch signaling activity in the seemingly identical primary ISVs that is independent of secondary sprouting and flow. We show that Notch signaling mediates the local patterning of ISVs, and an adaptive flow-mediated mechanism subsequently fine-tunes the global balance of arteries and veins along the trunk. We propose that this dual mechanism provides the adaptability required to establish a balanced network of arteries, veins and lymphatic vessels

First Record Along The Uruguayan Coast Of The Largest Sea Nettle Jellyfish, Chrysaora Plocamia (lesson, 1830) (cnidaria: Scyphozoa)

Chrysaora plocamia is one of the 15 species of the jellyfish genus Chrysaora. This species has an unusualdistribution pattern, occurring on both Atlantic and Pacific coasts of South America. It is distributed along the southeastern Pacific Ocean, encompassing coastal areas of Peru and Chile, and reaching the Patagonian coast of Argentina in the southwestern Atlantic. During two separate events, two large specimens of Chrysaora were collected on the east coast of Uruguay at La Paloma. Based on morphology and molecular data, these specimens were identified as Chrysaora plocamia. These records are described along with oceanographic features observed at that time. Unusual oceanographic and atmospheric conditions may explain the presence of these specimens 1,100 km north of the current northernmost known distribution. © 2016 Check List and Authors.12

Actividad física y salud percibida en pacientes con enfermedad coronaria

La enfermedad coronaria es una de las principales causas de morbilidad y mortalidad en el mundo y se asocia con importantes consecuencias emocionales y sociales. La actividad física parece ralentizar el inicio y la progresión de las enfermedades cardiovasculares pero también presenta beneficios sobre la salud psicosocial. El presente estudio tiene como objetivo el análisis de la relación entre la práctica de actividad física y la calidad de vida, el bienestar psicológico y la depresión en pacientes con enfermedad coronaria. La muestra estaba compuesta por 275 personas, con edades entre 54 a 98 años. Se aplicó un Cuestionario Sociodemográfico, el Cuestionario de Salud SF-36, la Escala de Depresión Geriátrica (GDS), la Escala de Bienestar Psicológico (EBP) y el Cuestionario de Actividad Física de Yale (YPAS). Los resultados obtenidos pusieron de manifiesto que la práctica de actividad física se asociaba en pacientes con enfermedad coronaria a una mejora en las distintas escalas del Cuestionario de Salud SF-36 y en la Escala de Depresión Geriátrica, confirmando su importancia para el mantenimiento de la calidad de vida relacionada con la salud en estos pacientes

Role of Histamine H4 Receptor ligands in Bleomycin-induced pulmonary fibrosis

Fibrosis of lung tissue is a disease where a chronic inflammatory process determines a pathological remodelling of lung parenchyma. The animal model obtained by intra-tracheal administration of bleomycin in C57BL/6 mice is one of the most validated murine model. Bleomycin stimulates oxidative stress and the production of pro-inflammatory mediators. Histamine H4R have recently been implicated in inflammation and immune diseases. This study was focused to investigate the effects of H4R ligands in the modulation of inflammation and in the reduction of lung fibrosis in C57BL/6 mice treated with bleomycin. C57BL/6 mice were treated with vehicle, JNJ7777120 (JNJ, selective H4R antagonist) or ST-1006 (partial H4R agonist), ST-994 (H4R neutral antagonist) and ST-1012 (inverse H4R agonist) at equimolar doses, released by micro-osmotic pumps for 21 days. Airway resistance to inflation was assayed and lung samples were processed to measure malondialdehyde (TBARS); 8-hydroxy-2'-deoxyguanosine (8OHdG); myeloperoxidase (MPO); COX-2 expression and activity as markers of oxidative stress and inflammation. Fibrosis and airway remodelling were evaluated throughout transforming growth factor-β (TGF-β), percentage of positive Goblet cells, smooth muscle layer thickness determination. Our results indicated that JNJ, ST-994 and ST-1012 decreased inflammation and oxidative stress markers, i.e. the number of infiltrating leukocytes evaluated as lung tissue MPO, COX-2 expression and activity, TBARS and 8OHdG production. They also reduced the level of TGF-β, a pro-fibrotic cytokine, collagen deposition, thickness of smooth muscle layer, Goblet cells hyperplasia; resulting in a decrease of airway functional impairment. The results here reported clearly demonstrated that H4R ligands have a beneficial effect in a model of lung fibrosis in the mouse, thus indicating that H4R antagonists or inverse agonists could be a novel therapeutic strategy for lung inflammatory diseases

Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study.

Tumor budding has been reported to be an independent prognostic factor in pancreatic ductal adenocarcinoma (PDAC). Its use in daily diagnostics would improve the prognostic stratification of patients. We performed a multicenter interobserver study to test various budding assessment methods for their reproducibility. Two serial sections of 50 resected, treatment-naïve PDACs were stained for Hematoxylin and Eosin (H&E) and pancytokeratin. Tumor budding was scored by independent observers at five participating centers in Switzerland, Germany, and Canada. Pathologists assessed tumor budding on a digital platform comparing H&E with pancytokeratin staining in 10 high-power fields (10HPF) and one HPF hotspot (1HPF). Additionally, tumor budding was assessed in one H&E hotspot at × 20 magnification, as suggested by the International Tumor Budding Consensus Conference (ITBCC). Correlation coefficients for bud counts between centers ranged from r = 0.58648 to r = 0.78641 for H&E and from r = 0.69288 to r = 0.81764 for pancytokeratin. The highest interobserver agreement across all centers was observed for pancytokeratin 10HPFs (ICC = 0.6). ICC values were 0.49, 0.48, 0.41, and 0.4 for H&E in 1HPF hotspot, H&E in 10HPFs, pancytokeratin in 1HPF, and H&E in one hotspot at ×20, respectively (ITBCC method). This interobserver study reveals a range between moderately poor to moderate agreement levels between pathologists for the different tumor budding assessment methods in PDAC. Acceptable levels of agreement were reached with the pancytokeratin 10HPF method, which can thus be recommended for the assessment of tumor budding in PDAC resection specimens. To improve the levels of interobserver agreement, the implementation of machine learning applications should be considered