Prospecção de agentes de controle biológico para o manejo de ácaros pragas em culturas de solanáceas no DF e entorno.

Siconbiol

Drosophila Insulin Pathway Mutants Affect Visual Physiology and Brain Function Besides Growth, Lipid, and Carbohydrate Metabolism

OBJECTIVE—Type 2 diabetes is the most common form of diabetes worldwide. Some of its complications, such as retinop-athy and neuropathy, are long-term and protracted, with an un-clear etiology. Given this problem, genetic model systems, such as in flies where type 2 diabetes can be modeled and studied, offer distinct advantages. RESEARCH DESIGN AND METHODS—We used individual flies, control, and mutant individuals with partial loss-of-function insulin pathway genes. We measured wing size and tested body weight for growth phenotypes, the latter by means of a microbal-ance. We studied total lipid and carbohydrate content, lipids by a reaction in single fly homogenates with vanillin-phosphoric acid, and carbohydrates with an anthrone-sulfuric acid reaction. Cholinesterase activity was measured using the Ellman method in head homogenates from pooled fly heads, and electroretinogram

Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73-76

We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective measures of blood HbA1c, body mass index, diastolic and systolic blood pressure, and blood high-density lipoprotein to total cholesterol (HDL) ratio. APOE e4 allele was coded as either present or absent. WMH progression was measured on MRI over 3 years in 434 older adults, in a same-year-of-birth cohort. APOE e4 carriers with either a self-reported diagnosis of diabetes (β = 0.160, p = 0.002) or higher glycated hemoglobin levels (β = 0.114, p = 0.014) exhibited greater WMH progression, and the former survived correction for multiple testing. All other APOE-VRF interactions were nonsignificant (βinteraction < 0.056, p > 0.228). The results suggest that carrying the APOE “risk” e4 allele increases the risk of greater age-related WMH progression over the early part of the eighth decade of life, when combined with poorer glycemic control. The interaction effect was robust to co-occurring VRFs, suggesting a possible target for mitigating brain and cognitive aging at this age

Emotionally Difficult Experiences Faced by Medical Students During Training

Purpose To investigate (1) emotions-triggering situations faced by medical students; (2) their prevalence across training; (3) whether they aroused student׳s emotions, and (4) whether students׳ reactions varied across training. Method A pilot study analysed 60 written reports from 4th-year medical students from the Federal University of Ceará, Brazil, regarding recent emotionally difficult training experiences. Six types of emotions-triggering situations were chosen. A diary of a fictitious student reporting each situation was prepared, with two different endings – either a neutral or an emotional development. In a web-survey, 188 medical students evaluated those diary-entries (3 in a neutral; 3 in an emotional version), rating how frequently they had encountered similar situations and the emotions triggered by the reading. Data were analysed using Chi-square, t-tests and ANOVA. Results Frequency of similar experiences depended on situation type (p<.001) varying across training in 4 of the 6 situations. All situations were emotion-triggering, regardless of whether students had or not experienced them before. A significant main effect of training showed that students at different phases reacted differently; at the clinical phase emotional arousal was higher than in clerkship for 2 situations. Discussion Awareness of situations considered emotionally difficult may provide information for the development of educational interventions that emotionally support medical students