Decreased myocardial injury and improved contractility after administration of a peptide derived against the alpha-interacting domain of the L-type calcium channel.

BackgroundMyocardial infarction remains the leading cause of morbidity and mortality associated with coronary artery disease. The L-type calcium channel (IC a-L) is critical to excitation and contraction. Activation of the channel also alters mitochondrial function. Here, we investigated whether application of a alpha-interacting domain/transactivator of transcription (AID-TAT) peptide, which immobilizes the auxiliary β2 subunit of the channel and decreases metabolic demand, could alter mitochondrial function and myocardial injury.Methods and resultsTreatment with AID-TAT peptide decreased ischemia-reperfusion injury in guinea-pig hearts ex vivo (n=11) and in rats in vivo (n=9) assessed with uptake of nitroblue tetrazolium, release of creatine kinase, and lactate dehydrogenase. Contractility (assessed with catheterization of the left ventricle) was improved after application of AID-TAT peptide in hearts ex vivo (n=6) and in vivo (n=8) up to 12 weeks before sacrifice. In search of the mechanism for the effect, we found that intracellular calcium ([Ca(2+)]i, Fura-2), superoxide production (dihydroethidium fluorescence), mitochondrial membrane potential (Ψm, JC-1 fluorescence), reduced nicotinamide adenine dinucleotide production, and flavoprotein oxidation (autofluorescence) are decreased after application of AID-TAT peptide.ConclusionsApplication of AID-TAT peptide significantly decreased infarct size and supported contractility up to 12 weeks postcoronary artery occlusion as a result of a decrease in metabolic demand during reperfusion

Investigation of high energy radiation from a plasma focus

Included are seventeen topics covering the experimental setup, diagnostics, analyses and various applications of the plasma focus. An invention, a hypocycloidal-pinch apparatus, is also included

Entanglement growth in quench dynamics with variable range interactions

Studying entanglement growth in quantum dynamics provides both insight into the underlying microscopic processes and information about the complexity of the quantum states, which is related to the efficiency of simulations on classical computers. Recently, experiments with trapped ions, polar molecules, and Rydberg excitations have provided new opportunities to observe dynamics with long-range interactions. We explore nonequilibrium coherent dynamics after a quantum quench in such systems, identifying qualitatively different behavior as the exponent of algebraically decaying spin-spin interactions in a transverse Ising chain is varied. Computing the build-up of bipartite entanglement as well as mutual information between distant spins, we identify linear growth of entanglement entropy corresponding to propagation of quasiparticles for shorter range interactions, with the maximum rate of growth occurring when the Hamiltonian parameters match those for the quantum phase transition. Counter-intuitively, the growth of bipartite entanglement for long-range interactions is only logarithmic for most regimes, i.e., substantially slower than for shorter range interactions. Experiments with trapped ions allow for the realization of this system with a tunable interaction range, and we show that the different phenomena are robust for finite system sizes and in the presence of noise. These results can act as a direct guide for the generation of large-scale entanglement in such experiments, towards a regime where the entanglement growth can render existing classical simulations inefficient.Comment: 17 pages, 7 figure

Revealing quantum statistics with a pair of distant atoms

Quantum statistics have a profound impact on the properties of systems composed of identical particles. In this Letter, we demonstrate that the quantum statistics of a pair of identical massive particles can be probed by a direct measurement of the exchange symmetry of their wave function even in conditions where the particles always remain spatially well separated and thus the exchange contribution to their interaction energy is negligible. We present two protocols revealing the bosonic or fermionic nature of a pair of particles and discuss possible implementations with a pair of trapped atoms or ions.Comment: 4+13 pages, v2 corresponds to the version published by PR

Loading of a cold atomic beam into a magnetic guide

We demonstrate experimentally the continuous and pulsed loading of a slow and cold atomic beam into a magnetic guide. The slow beam is produced using a vapor loaded laser trap, which ensures two-dimensional magneto-optical trapping, as well as cooling by a moving molasses along the third direction. It provides a continuous flux larger than $10^9$ atoms/s with an adjustable mean velocity ranging from 0.3 to 3 m/s, and with longitudinal and transverse temperatures smaller than $100 \mu$K. Up to $3 10^8$ atoms/s are injected into the magnetic guide and subsequently guided over a distance of 40 cm.Comment: 10 pages, 10 figures, accepted for publication to EPJ

EIT ground-state cooling of long ion strings

Electromagnetically-induced-transparency (EIT) cooling is a ground-state cooling technique for trapped particles. EIT offers a broader cooling range in frequency space compared to more established methods. In this work, we experimentally investigate EIT cooling in strings of trapped atomic ions. In strings of up to 18 ions, we demonstrate simultaneous ground state cooling of all radial modes in under 1 ms. This is a particularly important capability in view of emerging quantum simulation experiments with large numbers of trapped ions. Our analysis of the EIT cooling dynamics is based on a novel technique enabling single-shot measurements of phonon numbers, by rapid adiabatic passage on a vibrational sideband of a narrow transition