Accurate holographic light potentials using pixel crosstalk modelling

Arbitrary light potentials have proven to be a valuable and versatile tool in many quantum information and quantum simulation experiments with ultracold atoms. Using a phase-modulating spatial light modulator (SLM), we generate arbitrary light potentials holographically with measured efficiencies between 15%−40% and an accuracy of below 2% root-mean-squared error. Key to the high accuracy is the modelling of pixel crosstalk of the SLM on a sub-pixel scale which is relevant especially for large light potentials. We employ conjugate gradient minimisation to calculate the SLM phase pattern for a given target light potential after measuring the intensity and wavefront at the SLM. Further, we use camera feedback to reduce experimental errors, we remove optical vortices and investigate the difference between the angular spectrum method and the Fourier transform to simulate the propagation of light. Using a combination of all these techniques, we achieved more accurate and efficient light potentials compared to previous studies, and generated a series of potentials relevant for cold atom experiments

Commensurate and incommensurate 1D interacting quantum systems

Single-atom imaging resolution of many-body quantum systems in optical lattices is routinely achieved with quantum-gas microscopes. Key to their great versatility as quantum simulators is the ability to use engineered light potentials at the microscopic level. Here, we employ dynamically varying microscopic light potentials in a quantum-gas microscope to study commensurate and incommensurate 1D systems of interacting bosonic Rb atoms. Such incommensurate systems are analogous to doped insulating states that exhibit atom transport and compressibility. Initially, a commensurate system with unit filling and fixed atom number is prepared between two potential barriers. We deterministically create an incommensurate system by dynamically changing the position of the barriers such that the number of available lattice sites is reduced while retaining the atom number. Our systems are characterised by measuring the distribution of particles and holes as a function of the lattice filling, and interaction strength, and we probe the particle mobility by applying a bias potential. Our work provides the foundation for preparation of low-entropy states with controlled filling in optical-lattice experiments.Comment: 12 pages, 10 figure

Instabilities of interacting matter waves in optical lattices with Floquet driving

We experimentally investigate the stability of a quantum gas with repulsive interactions in an optical one-dimensional lattice subjected to periodic driving. Excitations of the gas in the lowest lattice band are analyzed across the complete stability diagram, from slow to fast driving frequencies and from weak to strong driving strengths. To interpret our results, we expand the established analysis based on parametric instabilities to include modulational instabilities. Extending the concept of modulational instabilities from static to periodically driven systems provides a convenient mapping of the stability in a static system to the cases of slow and fast driving. At intermediate driving frequencies, we observe an interesting competition between modulational and parametric instabilities. We experimentally confirm the existence of both types of instabilities in driven systems and probe their properties. Our results allow us to predict stable and unstable parameter regions for the minimization of heating in future applications of Floquet driving

Phonon excitations of Floquet-driven superfluids in a tilted optical lattice

Tilted lattice potentials with periodic driving play a crucial role in the study of artificial gauge fields and topological phases with ultracold quantum gases. However, driving-induced heating and the growth of phonon modes restrict their use for probing interacting many-body states. Here, we experimentally investigate phonon modes and interaction-driven instabilities of superfluids in the lowest band of a shaken optical lattice. We identify stable and unstable parameter regions and provide a general resonance condition. In contrast to the high-frequency approximation of a Floquet description, we use the micromotion of the superfluids to analyze the growth of phonon modes from slow- to fast-driving frequencies. The model describes phonon excitations in both resonantly and nonresonantly driven systems, with or without a tilted potential. Our observations enable the prediction of stable parameter regimes for quantum-simulation experiments aimed at studying driven systems with strong interactions over extended time scales

Commensurate and incommensurate 1D interacting quantum systems

Single-atom imaging resolution of many-body quantum systems in optical lattices is routinely achieved with quantum-gas microscopes. Key to their great versatility as quantum simulators is the ability to use engineered light potentials at the microscopic level. Here, we employ dynamically varying microscopic light potentials in a quantum-gas microscope to study commensurate and incommensurate 1D systems of interacting bosonic Rb atoms. Such incommensurate systems are analogous to doped insulating states that exhibit atom transport and compressibility. Initially, a commensurate system with unit filling and fixed atom number is prepared between two potential barriers. We deterministically create an incommensurate system by dynamically changing the position of the barriers such that the number of available lattice sites is reduced while retaining the atom number. Our systems are characterised by measuring the distribution of particles and holes as a function of the lattice filling, and interaction strength, and we probe the particle mobility by applying a bias potential. Our work provides the foundation for preparation of low-entropy states with controlled filling in optical-lattice experiments

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge";: Napoli, December 3rd-6th 2014.

The fourth "Melanoma Bridge Meeting" took place in Naples, December 3-6th, 2014. The four topics discussed at this meeting were: Molecular and Immunological Advances, Combination Therapies, News in Immunotherapy, and Tumor Microenvironment and Biomarkers. Until recently systemic therapy for metastatic melanoma patients was ineffective, but recent advances in tumor biology and immunology have led to the development of new targeted and immunotherapeutic agents that prolong progression-free survival (PFS) and overall survival (OS). New therapies, such as mitogen-activated protein kinase (MAPK) pathway inhibitors as well as other signaling pathway inhibitors, are being tested in patients with metastatic melanoma either as monotherapy or in combination, and all have yielded promising results. These include inhibitors of receptor tyrosine kinases (BRAF, MEK, and VEGFR), the phosphatidylinositol 3 kinase (PI3K) pathway [PI3K, AKT, mammalian target of rapamycin (mTOR)], activators of apoptotic pathway, and the cell cycle inhibitors (CDK4/6). Various locoregional interventions including radiotherapy and surgery are still valid approaches in treatment of advanced melanoma that can be integrated with novel therapies. Intrinsic, adaptive and acquired resistance occur with targeted therapy such as BRAF inhibitors, where most responses are short-lived. Given that the reactivation of the MAPK pathway through several distinct mechanisms is responsible for the majority of acquired resistance, it is logical to combine BRAF inhibitors with inhibitors of targets downstream in the MAPK pathway. For example, combination of BRAF/MEK inhibitors (e.g., dabrafenib/trametinib) have been demonstrated to improve survival compared to monotherapy. Application of novel technologies such sequencing have proven useful as a tool for identification of MAPK pathway-alternative resistance mechanism and designing other combinatorial therapies such as those between BRAF and AKT inhibitors. Improved survival rates have also been observed with immune-targeted therapy for patients with metastatic melanoma. Immune-modulating antibodies came to the forefront with anti-CTLA-4, programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) pathway blocking antibodies that result in durable responses in a subset of melanoma patients. Agents targeting other immune inhibitory (e.g., Tim-3) or immune stimulating (e.g., CD137) receptors and other approaches such as adoptive cell transfer demonstrate clinical benefit in patients with melanoma as well. These agents are being studied in combination with targeted therapies in attempt to produce longer-term responses than those more typically seen with targeted therapy. Other combinations with cytotoxic chemotherapy and inhibitors of angiogenesis are changing the evolving landscape of therapeutic options and are being evaluated to prevent or delay resistance and to further improve survival rates for this patient population. This meeting's specific focus was on advances in combination of targeted therapy and immunotherapy. Both combination targeted therapy approaches and different immunotherapies were discussed. Similarly to the previous meetings, the importance of biomarkers for clinical application as markers for diagnosis, prognosis and prediction of treatment response was an integral part of the meeting. The overall emphasis on biomarkers supports novel concepts toward integrating biomarkers into contemporary clinical management of patients with melanoma across the entire spectrum of disease stage. Translation of the knowledge gained from the biology of tumor microenvironment across different tumors represents a bridge to impact on prognosis and response to therapy in melanoma

Accurate holographic light potentials for cold-atom experiments

We holographically generate light potentials on a microscopic scale relevant for cold-atom experiments using a liquid crystal spatial light modulator and two high-NA microscope objectives. The root-mean-squared error of our potentials falls within the range of 3.6 − 6.2%

Floquet Solitons and Dynamics of Periodically Driven Matter Waves with Negative Effective Mass

We experimentally study the dynamics of weakly interacting Bose-Einstein condensates of cesium atoms in a 1D optical lattice with a periodic driving force. After a sudden start of the driving, we observe the formation of stable wave packets at the center of the first Brillouin zone (BZ) in momentum space, and we interpret these as Floquet solitons in periodically driven systems. The wave packets become unstable when we add a trapping potential along the lattice direction, leading to a redistribution of atoms within the BZ. The concept of a negative effective mass and the resulting changes to the interaction strength and effective trapping potential are used to explain the stability and the time evolution of the wave packets. We expect that similar states of matter waves exist for discrete breathers and other types of lattice solitons in periodically driven systems

An optical elevator for precise delivery of cold atoms using an acousto-optical deflector

We implement a simple method for fast and precise delivery of ultracold atoms to a microscopic device, ie a Fabry–Perot microcavity. By moving a single beam optical dipole trap in a direction perpendicular to the beam axis with an acousto-optical deflector, we transport up to 1 million atoms within 100 ms over 1 cm. Under these conditions, a transport efficiency above 95% is achieved with only minimal heating. The atomic cloud is accurately positioned within the microcavity and transferred into an intra-cavity optical lattice. With the addition of a secondary guiding beam, we show how residual sloshing motion along the shallow axis of the trap can be minimized