Therapeutic and Metagenomic Potential of the Biomolecular Therapies against Periodontitis and the Oral Microbiome: Current Evidence and Future Perspectives

The principles of periodontal therapy are based on the control of microbial pathogens and host factors that contribute to biofilm dysbiosis, with the aim of modulating the progression of periodontitis and periodontal tissue destruction. It is currently known how differently each individual responds to periodontal treatment, depending on both the bacterial subtypes that make up the dysbiotic biofilm and interindividual variations in the host inflammatory response. This has allowed the current variety of approaches for the management of periodontitis to be updated by defining the goals of target strategies, which consist of reducing the periodontopathogenic microbial flora and/or modulating the host-mediated response. Therefore, this review aims to update the current variety of approaches for the management of periodontitis based on recent target therapies. Recently, encouraging results have been obtained from several studies exploring the effects of some targeted therapies in the medium- and long-term. Among the most promising target therapies analyzed and explored in this review include: cell-based periodontal regeneration, mediators against bone resorption, emdogain (EMD), platelet-rich plasma, and growth factors. The reviewed evidence supports the hypothesis that the therapeutic combination of epigenetic modifications of periodontal tissues, interacting with the dysbiotic biofilm, is a key step in significantly reducing the development and progression of disease in periodontal patients and improving the therapeutic response of periodontal patients. However, although studies indicate promising results, these need to be further expanded and studied to truly realize the benefits that targeted therapies could bring in the treatment of periodontitis

Challenges in plasma and laser wakefield accelerated beams diagnostic

The new frontier in the particle beam accelerator is the so called plasma acceleration. Using the strong electric eld inside a plasma is possible to achieve accelerating gradients order of magnitude larger with respect to the actual technologies. Di erent schemes have been proposed and several already tested, producing beams of energy of several GeV. Mainly two approaches are followed: either the beam is directly produced by the interaction of a TW/PW class laser with a gas jet, or a preexisting particle beam is accelerated in a plasma channel. In both cases a precise determination of the emerging beam parameters is mandatory for the ne tuning of the devices. The measurement of these parameters, in particular the emittance, is not trivial, mainly due to the large energy spread and to the tight focusing of these beams or to the background noise produced in the plasma channel. We show the problems related to the diagnostic of this kind of beams and the proposed or already realized solutions

Beam commissioning of the 35 MeV section in an intensity modulated proton linear accelerator for proton therapy

This paper presents the experimental results on the Terapia Oncologica con Protoni-Intensity Modulated Proton Linear Accelerator (TOP-IMPLART) beam that is currently accelerated up to 35 MeV, with a final target of 150 MeV. The TOP-IMPLART project, funded by the Innovation Department of Regione Lazio (Italy), is led by Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA) in collaboration with the Italian Institute of Health and the Oncological Hospital Regina Elena-IFO. The accelerator, under construction and test at ENEA-Frascati laboratories, employs a commercial 425 MHz, 7 MeV injector followed by a sequence of 3 GHz accelerating modules consisting of side coupled drift tube linac (SCDTL) structures up to 71 MeV and coupled cavity linac structures for higher energies. The section from 7 to 35 MeV, consisting on four SCDTL modules, is powered by a single 10 MW klystron and has been successfully commissioned. This result demonstrates the feasibility of a “fully linear” proton therapy accelerator operating at a high frequency and paves the way to a new class of machines in the field of cancer treatment

The THz radiation source at SPARC

The linac driven coherent THz radiation source at the SPARC facility is able to deliver broadband THz pulses with femtosecond shaping. In addition, high peak power, narrow-band THz radiation can be also generated, taking advantage from advanced electron beam manipulation techniques, able to generate a train of short electron bunches with THz repetition rate

The THz Radiation Source at the SPARC Facility

The interest for Terahertz (THz) radiation is rapidly growing, both as it is a powerful tool for investigating the behavior of matter at low energy, and as it allows for a number of possible spectroscopic applications spanning from medical science to security. The linacdriven THz source at the SPARC facility can deliver broadband THz pulses with femtosecond shaping and can be used for electron beam diagnostics to fully reconstruct the longitudinal charge distribution. Beyond this application, the possibility to store much more energy in a single THz pulse than table-top sources renders the SPARC THz source very interesting for a spectroscopic use. In addition, taking advantage from electron beam manipulation techniques, high power, narrow-band THz radiation can be also generated. Those source characteristics provide a unique chance to realize THz-pump/THz-probe spectroscopy, a technique practically unexplored up to now

Overview of Plasma Lens Experiments and Recent Results at SPARC_LAB

Beam injection and extraction from a plasma module is still one of the crucial aspects to solve in order to produce high quality electron beams with a plasma accelerator. Proper matching conditions require to focus the incoming high brightness beam down to few microns size and to capture a high divergent beam at the exit without loss of beam quality. Plasma-based lenses have proven to provide focusing gradients of the order of kT/m with radially symmetric focusing thus promising compact and affordable alternative to permanent magnets in the design of transport lines. In this paper an overview of recent experiments and future perspectives of plasma lenses is reported

PRESENT AND PERSPECTIVES OF THE SPARC THz SOURCE

The development of radiation sources in the Terahertz (THz) spectral region has become more and more interesting because of the peculiar characteristics of this radiation: it is non ionizing, it penetrates dielectrics, it is highly absorbed by polar liquids, highly reflected by metals and reveals specific “fingerprint”absorption spectra arising from fundamentals physical processes. The THz source at SPARC is a linac-based source for both longitudinal beam diagnostics and research investigations. Its measured peak power is of the order of 108 W, very competitive with respect to other present sources. The status of the THz radiation source, in particular its generation and properties, is presented and future perspectives are discusse

Large-bandwidth two-color free-electron laser driven by a comb-like electron beam

We discuss a two-color SASE free-electron laser (FEL) amplifier where the time and energy separation of two separated radiation pulses are controlled by manipulation of the electron beam phase space. Two electron beamlets with adjustable time and energy spacing are generated in an RF photo-injector illuminating the cathode with a comb-like laser pulse followed by RF compression in the linear accelerator. We review the electron beam manipulation technique to generate bunches with time and energy properties suitable for driving two-color FEL radiation. Experimental measurements at the SPARC-LAB facility illustrate the flexibility of the scheme for the generation of two-color FEL spectr

Observation of Time-Domain Modulation of Free-Electron-Laser Pulses by Multipeaked Electron-Energy Spectrum

We present the experimental demonstration of a new scheme for the generation of ultrashort pulse trains based on free-electron-laser (FEL) emission from a multipeaked electron energy distribution. Two electron beamlets with energy difference larger than the FEL parameter have been generated by illuminating the cathode with two ps-spaced laser pulses, followed by a rotation of the longitudinal phase space by velocity bunching in the linac. The resulting self-amplified spontaneous emission FEL radiation, measured through frequency-resolved optical gating diagnostics, reveals a double-peaked spectrum and a temporally modulated pulse structure