Catching Element Formation In The Act

Gamma-ray astronomy explores the most energetic photons in nature to address some of the most pressing puzzles in contemporary astrophysics. It encompasses a wide range of objects and phenomena: stars, supernovae, novae, neutron stars, stellar-mass black holes, nucleosynthesis, the interstellar medium, cosmic rays and relativistic-particle acceleration, and the evolution of galaxies. MeV gamma-rays provide a unique probe of nuclear processes in astronomy, directly measuring radioactive decay, nuclear de-excitation, and positron annihilation. The substantial information carried by gamma-ray photons allows us to see deeper into these objects, the bulk of the power is often emitted at gamma-ray energies, and radioactivity provides a natural physical clock that adds unique information. New science will be driven by time-domain population studies at gamma-ray energies. This science is enabled by next-generation gamma-ray instruments with one to two orders of magnitude better sensitivity, larger sky coverage, and faster cadence than all previous gamma-ray instruments. This transformative capability permits: (a) the accurate identification of the gamma-ray emitting objects and correlations with observations taken at other wavelengths and with other messengers; (b) construction of new gamma-ray maps of the Milky Way and other nearby galaxies where extended regions are distinguished from point sources; and (c) considerable serendipitous science of scarce events -- nearby neutron star mergers, for example. Advances in technology push the performance of new gamma-ray instruments to address a wide set of astrophysical questions.Comment: 14 pages including 3 figure

On the Low Surface Magnetic Field Structure of Quark Stars

Following some of the recent articles on hole super-conductivity and related phenomena by Hirsch \cite{H1,H2,H3}, a simple model is proposed to explain the observed low surface magnetic field of the expected quark stars. It is argued that the diamagnetic moments of the electrons circulating in the electro-sphere induce a magnetic field, which forces the existing quark star magnetic flux density to become dilute. We have also analysed the instability of normal-superconducting interface due to excess accumulation of magnetic flux lines, assuming an extremely slow growth of superconducting phase through a first order bubble nucleation type transition.Comment: 24 pages REVTEX, one .eps figure, psfig.sty is include

A NOVEL ROLLING BASED DNA CRYPTOGRAPHY

DNA Cryptography can be defined as a hiding data in terms of DNA Sequence. In this paper we propose a new DNA Encryption Technique where three different types of ordering is use to make binary data into cipher text. The main stages of this encryption technique are: Key Analysis, Data and Key Arrangement, Roll in encoding, Secondary Arrangement and Shifting. Decryption process has six main steps to obtain the original binary data from the encrypted data and key. Decryption steps are: Key Analysis, Shifting, Secondary Arrangement, Key Arrangement, Roll-out decoding, Data Arrangement. Here key size is half of binary data and the key is varies from data to data so key are used as one time pad. In this paper we also discuss about the implementation from sample data and security analysis for this given method

Quinone-Amino Acid Conjugates Targeting <i>Leishmania</i> Amino Acid Transporters

<div><p>The aim of the present study was to investigate the feasibility of targeting <i>Leishmania</i> transporters via appropriately designed chemical probes. <i>Leishmania donovani</i>, the parasite that causes visceral leishmaniasis, is auxotrophic for arginine and lysine and has specific transporters (LdAAP3 and LdAAP7) to import these nutrients. Probes <b>1–15</b> were originated by conjugating cytotoxic quinone fragments (<b>II</b> and <b>III</b>) with amino acids (i.e. arginine and lysine) by means of an amide linkage. The toxicity of the synthesized conjugates against <i>Leishmania</i> extracellular (promastigotes) and intracellular (amastigotes) forms was investigated, as well their inhibition of the relevant amino acid transporters. We observed that some conjugates indeed displayed toxicity against the parasites; in particular, <b>7</b> was identified as the most potent derivative (at concentrations of 1 µg/mL and 2.5 µg/mL residual cell viability was reduced to 15% and 48% in promastigotes and amastigotes, respectively). Notably, <b>6</b>, while retaining the cytotoxic activity of quinone <b>II</b>, displayed no toxicity against mammalian THP1 cells. Transport assays indicated that the novel conjugates inhibited transport activity of lysine, arginine and proline transporters. Furthermore, our analyses suggested that the toxic conjugates might be translocated by the transporters into the cells. The non-toxic probes that inhibited transport competed with the natural substrates for binding to the transporters without being translocated. Thus, it is likely that <b>6</b>, by exploiting amino acid transporters, can selectively deliver its toxic effects to <i>Leishmania</i> cells. This work provides the first evidence that amino acid transporters of the human pathogen <i>Leishmania</i> might be modulated by small molecules, and warrants their further investigation from drug discovery and chemical biology perspectives.</p></div