Dynamic Characteristic Analysis of Large Space Deployable Articulated Mast

AbstractEquivalent continuum beam model and finite element model of space deployable articulated mast are developed. Dynamic characteristics of the mast without and with tip load are analyzed based on two models respectively. Frequencies and mode shapes of the mast are calculated and simulated by Euler beam theory and finite element simulation, and theoretical solutions are compared with simulation results. Influence of mast structural parameters on mast natural frequencies is analyzed, the sensitivities of mast bending, torsional, axial frequencies to structural parameters are calculated. The measure for improving mast dynamic characteristic is proposed through sensitivity analysis

New Protections for Healthcare Workers

<p>Supplemental material, Video 1: sj-vid-1-pic-10.1177 0954406218779612 for Self-adaptive grasp analysis of a novel under-actuated cable-truss robotic finger by Shangling Qiao, Hongwei Guo, Rongqiang Liu, Yong Huang and Zongquan Deng in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science</p

Design and Dynamic Equivalent Modeling of Double-Layer Hoop Deployable Antenna

This study proposes deployable units driven by elastic hinges and a double-layer hoop deployable antenna composed of these units. A rational modeling method based on the energy equivalence principle is presented to develop an equivalent model of the double-layer hoop antenna in accordance with the structural characteristics of the antenna. The equivalent beam models of the rods with elastic hinges are proposed. The relationship of geometrical and material parameters is established considering the strain energy and the kinetic energy of the periodic unit, which are the same as those of the equivalent beam in the same displacement field. The equivalent model of the antenna is obtained by assembling several equivalent beam models in the circumferential direction. The precision of the equivalent model of the antenna is acceptable as found by comparing the modal analysis results obtained through equivalent model calculation, finite element simulation, and modal test

Investigating causal associations among gut microbiota, metabolites, and liver diseases: a Mendelian randomization study

ObjectiveThere is some evidence for an association between gut microbiota and nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and viral hepatitis, but no studies have explored their causal relationship.MethodsInstrumental variables of the gut microbiota (N = 13266) and gut microbiota-derived metabolites (N = 7824) were acquired, and a Mendelian randomization study was performed to explore their influence on NAFLD (1483 European cases and 17,781 European controls), ALD (2513 European cases and 332,951 European controls), and viral hepatitis risk (1971 European cases and 340,528 European controls). The main method for examining causality is inverse variance weighting (IVW).ResultsIVW results confirmed that Anaerotruncus (p = 0.0249), Intestinimonas (p = 0.0237), Lachnoclostridium (p = 0.0245), Lachnospiraceae NC2004 group (p = 0.0083), Olsenella (p = 0.0163), and Peptococcus (p = 0.0472) were protective factors for NAFLD, and Ruminococcus 1 (p = 0.0120) was detrimental for NAFLD. The higher abundance of three genera, Lachnospira (p = 0.0388), Desulfovibrio (p = 0.0252), and Ruminococcus torques group (p = 0.0364), was correlated with a lower risk of ALD, while Ruminococcaceae UCG 002 level was associated with a higher risk of ALD (p = 0.0371). The Alistipes (p = 0.0069) and Ruminococcaceae NK4A214 group (p = 0.0195) were related to a higher risk of viral hepatitis. Besides, alanine (p = 0.0076) and phenyllactate (p = 0.0100) were found to be negatively correlated with NAFLD, while stachydrine (Op = 0.0244) was found to be positively associated with NAFLD. The phenylacetate (p = 0.0353) and ursodeoxycholate (p = 0.0144) had a protective effect on ALD, while the threonate (p = 0.0370) exerted a detrimental influence on ALD. The IVW estimates of alanine (p = 0.0408) and cholate (p = 0.0293) showed their suggestive harmful effects against viral hepatitis, while threonate (p = 0.0401) displayed its suggestive protective effect against viral hepatitis.ConclusionIn conclusion, our research supported causal links between the gut microbiome and its metabolites and NAFLD, ALD, and viral hepatitis

Voltage regulation strategy for alternating current microgrid under false data injection attacks

This study introduces a robust strategy for regulating output voltage in the presence of false data injection (FDI) attacks. Employing a hierarchical approach, we disentangle the distributed secondary control problem into two distinct facets: an observer-based resilient tracking control problem and a decentralized control problem tailored for real systems. Notably, our strategy eliminates the reliance on global information and effectively mitigates the impact of FDI attacks on directed communication networks. Ultimately, simulation results corroborate the efficacy of our approach, demonstrating successful voltage regulation within the system and proficient management of FDI attacks

The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis

Objective Selenium deficiency is a risk factor for Kashin-Beck Disease (KBD), an endemic osteoarthropathy. Although promoter hypermethylation of glutathione peroxidase 3 (GPX3) (a selenoprotein) has been identified in several cancers, little is known about promoter methylation and expression of GPX3 and their relation to selenium in KBD. The present study was thus conducted to investigate this research question. Methods Methylation and expressions of GPX3 in whole blood drawn from 288 KBD patients and 362 healthy controls and in chondrocyte cell line were evaluated using methylation-specific PCR and qRT-PCR, respectively. The protein levels of PI3K/Akt/c-fos signaling in the whole blood and chondrocyte cell line were determined with Western blotting. Chondrocytes apoptosis were detected by Hoechst 33342 and Annexin V-FITC/PI staining. Results GPX3 methylation was increased, GPX3 mRNA was decreased, and protein levels in the PI3K/Akt/c-fos signaling pathway were up-regulated in the whole blood collected from KBD patients as compared with healthy controls. Similar results were obtained for chondrocytes injured by oxidative stress. There was a significant, decreasing trend in GPX3 expression across groups of unmethylation, partial methylation, and complete methylation for GPX3, in sequence. Compared with unmethylation group, protein levels in PI3K/Akt/c-fos pathway were enhanced in partial and complete methylation groups. Treatment of chondrocytes with sodium selenite resulted in reduced methylation and increased expression of GPX3 as well as down-regulated level of PI3K/Akt/c-fos proteins. Conclusions The methylation and expression of GPX3 and expression of PI3K/Akt/c-fos pathway are altered in KBD and these changes are reversible by selenium supplementation

Human Streptococcus suis Outbreak, Sichuan, China

Streptococcus suis outbreak was associated with exposure to sick or dead pigs