A Study of the Administrative Development of Academic Department Chairpersons in Selected Institutions of Higher Education.

Non

Mediación contemplativa y resolución de problemas algebraicos en entornos virtuales

Se reporta una investigación realizada con estudiantes para profesor de matemática de la Universidad Pedagógica Experimental Libertador en su núcleo de Maracay, estado Aragua en Venezuela, y que forma parte de un estudio mucho más amplio del tipo cualitativo que tiene por título Desarrollo del Pensamiento Algebraico en Entornos de Aprendizaje Mediados Tecnológicamente que tiene entre sus objetivos construir un sistema categórico conceptual explicativo de las relaciones entre el desarrollo de los procesos del pensamiento algebraico y la mediación tecnológica. En lo concerniente a investigaciones del tipo cualitativista-interpretativos, que involucran la mediación tecnológica, existen muchos aspectos por aclarar en lo que respecta a las técnicas, instrumentos y procedimientos. Por ello puede resultar esclarecedor ensayar métodos con un espectro pequeño contenido en la investigación amplia en aras de ir conformando, junto a la teoría existente y la emergente, una metodología definitiva. Desde esta perspectiva, este trabajo trata de la presentación de un resultado parcial basado en el análisis de un caso particular de interacción virtual entre estudiantes y profesor en relación con un ejercicio de Álgebra Lineal, esperando allanar el camino en la metódica del trabajo macro con miras a la exploración definitiva de la información que se recoja. Como interrogantes de investigación se plantean las siguientes, (1) ¿Cuáles son las características de las interacciones virtuales cuando se enseña y aprende un contenido matemático específico?, y (2) ¿Qué conocimientos metodológicos, en relación con la investigación macro, puede aportar el estudio de un caso particular de teleinteracción? A fin de darle respuestas a estas interrogantes se trazaron los siguientes objetivos:(1) examinar algunos elementos eventuales de la dinámica de las teleinteracciones durante el proceso de enseñanza y aprendizaje de un contenido matemático específico en un contexto de mediación tecnológica, y (2) explicitar el aprendizaje que puede aportar el estudio de un caso particular en la construcción de la metodología definitiva para el análisis de la información global. Los sujetos involucrados fueron los integrantes de dos secciones del Curso Álgebra Lineal del Instituto Pedagógico de Maracay durante el período académico 2008-II, los instrumentos empleados fueron los Foros de la Plataforma Moodle, el procedimiento consistió en la organización e implementación de un foro virtual el cual se inserta en un curso presencial de Álgebra Lineal con apoyo de esta plataforma. El análisis de la información consistió en el examen de los errores y aciertos cometidos por los estudiantes en relación con un problema particular de Álgebra Lineal

Direct Tension Recording From Smooth Muscle of Resistance Vessels From Various Organs

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67115/2/10.1177_000331976101201009.pd

Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137765/1/cncy21859.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137765/2/cncy21859_am.pd

Pancreatoblastoma: Cytologic and histologic analysis of 12 adult cases reveals helpful criteria in their diagnosis and distinction from common mimics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152894/1/cncy22187_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/152894/2/cncy22187.pd

Molecular testing for the clinical diagnosis of fibrolamellar carcinoma.

Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including cytokeratin 7 and CD68 co-expression. Despite the distinct findings, accurate diagnosis of fibrolamellar carcinoma continues to be a challenge. Recently, fibrolamellar carcinomas were found to harbor a characteristic somatic gene fusion, DNAJB1-PRKACA. A break-apart fluorescence in situ hybridization (FISH) assay was designed to detect this fusion event and to examine its diagnostic performance in a large, multicenter, multinational study. Cases initially classified as fibrolamellar carcinoma based on histological features were reviewed from 124 patients. Upon central review, 104 of the 124 cases were classified histologically as typical of fibrolamellar carcinoma, 12 cases as 'possible fibrolamellar carcinoma' and 8 cases as 'unlikely to be fibrolamellar carcinoma'. PRKACA FISH was positive for rearrangement in 102 of 103 (99%) typical fibrolamellar carcinomas, 9 of 12 'possible fibrolamellar carcinomas' and 0 of 8 cases 'unlikely to be fibrolamellar carcinomas'. Within the morphologically typical group of fibrolamellar carcinomas, two tumors with unusual FISH patterns were also identified. Both cases had the fusion gene DNAJB1-PRKACA, but one also had amplification of the fusion gene and one had heterozygous deletion of the normal PRKACA locus. In addition, 88 conventional hepatocellular carcinomas were evaluated with PRKACA FISH and all were negative. These findings demonstrate that FISH for the PRKACA rearrangement is a clinically useful tool to confirm the diagnosis of fibrolamellar carcinoma, with high sensitivity and specificity. A diagnosis of fibrolamellar carcinoma is more accurate when based on morphology plus confirmatory testing than when based on morphology alone

Imaging features of bile duct adenoma: case series and review of literature

PURPOSE:We aimed to evaluate the imaging features of bile duct adenoma (BDA) on ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI).METHODS:Retrospective search in our institution database was performed for histologically confirmed BDA. Their imaging studies before histologic confirmation were reviewed. The search identified seven adults (mean age, 52.9 years) with histologically proven single BDA each. US (n=3), CT (n=5), and MRI (n=3) were performed before histologic confirmation. Additionally, a systematic English literature review for BDA and reported imaging findings since 2000 was also conducted using the following search criteria “bile duct adenoma, peribiliary hamartoma, biliary adenoma, CT, ultrasound, MRI” (date range: 01/01/2000 through 08/31/2016). The imaging findings of those cases reported were summarized and compared with our series.RESULTS:All seven individual nodules were well circumscribed. Five lesions were located in the right hepatic lobe and two in the left hepatic lobe. On US, lesions appeared hypoechoic (n=2) and hyperechoic (n=1). BDA was hypodense on unenhanced CT images (n=1). On MRI, BDA were hypointense on T1 (n=3), hyperintense on T2 (n=3), and hyperintense on diffusion-weighted images (n=2). On contrast-enhanced CT and MRI, BDAs showed arterial phase hyperenhancement that persisted on portal venous/delayed phase images.CONCLUSION:BDA demonstrates characteristic arterial phase hyperenhancement that persisted into the portal venous and delayed phases on CT and MRI, which may be useful in differentiating from other hepatic lesions

Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma

Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLCs. We demonstrate that FLC tumors (n = 6) exhibit distinct messenger RNA (mRNA) and long intergenic non-coding RNA (lincRNA) profiles compared to hepatocellular carcinoma (n = 263) and cholangiocarcinoma (n = 36), the two most common liver cancers. We also identify a set of mRNAs (n = 16) and lincRNAs (n = 4), including LINC00473, that distinguish FLC from ~25 other liver and non-liver cancer types. We confirm this unique FLC signature by analysis of two independent FLC cohorts (n = 20 and 34). Lastly, we validate the overexpression of one specific gene in the FLC signature, carbonic anhydrase XII (CA12), at the protein level by western blot and immunohistochemistry. Both the mRNA and lincRNA signatures support a major role for protein kinase A (PKA) signaling in shaping the FLC gene expression landscape, and present novel candidate FLC oncogenes that merit further investigation

Nanoceria: A Rare-Earth Nanoparticle as a Novel Anti-Angiogenic Therapeutic Agent in Ovarian Cancer

Ovarian cancer (OvCa) is the fifth most common cause of death from all cancers among women in United Sates and the leading cause of death from gynecological malignancies. While most OvCa patients initially respond to surgical debulking and chemotherapy, 75% of patients later succumb to the disease. Thus, there is an urgent need to test novel therapeutic agents to counteract the high mortality rate associated with OvCa. In this context, we have developed and engineered Nanoceria (NCe), nanoparticles of cerium oxide, possessing anti-oxidant properties, to be used as a therapeutic agent in OvCa. We show for the first time that NCe significantly inhibited production of reactive oxygen species (ROS) in A2780 cells, attenuated growth factor (SDF1, HB-EGF, VEGF(165) and HGF) mediated cell migration and invasion of SKOV3 cells, without affecting the cell proliferation. NCe treatment also inhibited VEGF165 induced proliferation, capillary tube formation, activation of VEGFR2 and MMP2 in human umbilical vascular endothelial cells (HUVEC). NCe (0.1 mg/kg body weigh) treatment of A2780 ovarian cancer cells injected intra-peritoneally in nude mice showed significant reduction (p \u3c 0.002) in tumor growth accompanied by decreased tumor cell proliferation as evident from reduced tumor size and Ki67 staining. Accumulation of NCe was found in tumors isolated from treated group using transmission electron microscopy (TEM) and inductively coupled plasma mass spectroscopy (ICP-MS). Reduction of the tumor mass was accompanied by attenuation of angiogenesis, as observed by reduced CD31 staining and specific apoptosis of vascular endothelial cells. Collectively, these results indicate that cerium oxide based NCe is a novel nanoparticle that can potentially be used as an anti-angiogenic therapeutic agent in ovarian cancer