Monte Carlo simulations of infinitely dilute solutions of amphiphilic diblock star copolymers

Single-chain Monte Carlo simulations of amphiphilic diblock star copolymers were carried out in continuous space using implicit solvents. Two distinct architectures were studied: stars with the hydrophobic blocks attached to the core, and stars with the polar blocks attached to the core, with all arms being of equal length. The ratio of the lengths of the hydrophobic block to the length of the polar block was varied from 0 to 1. Stars with 3, 6, 9 or 12 arms, each of length 10, 15, 25, 50, 75 and 100 Kuhn segments were analysed. Four distinct types of conformations were observed for these systems. These, apart from studying the snapshots from the simulations, have been quantitatively characterised in terms of the mean-squared radii of gyration, mean-squared distances of monomers from the centre-of-mass, asphericity indices, static scattering form factors in the Kratky representation as well as the intra-chain monomer-monomer radial distribution functions.Comment: 12 pages, 11 ps figures. Accepted for publication in J. Chem. Phy

Three-dimensional imaging of steeply dipping structure near the San Andreas fault, Parkfield, California

Shot gathers from the Parkfield, California, deep crustal seismic reflection line, recorded in 1977 by COCORP, reveal coherent events having horizontal to reverse moveouts. These events were migrated using a multioffset three-dimensional Kirchhoff summation method. This method is a ray-equation back projection inversion of the acoustic wave field, which is valid under the Born, WKBJ, and far-field assumptions. Migration of full-wave acoustic synthetics, having the same limitations in geometric coverage as the COCORP survey, demonstrates the utility of the imaging process. The images obtained from back projection of the survey data suggest that the Gold Hill fault carries ultramafic rocks from the surface to 3 km depth at a dip greater than 45 degrees, where it joins the San Andreas fault, which may cut through more homogeneous materials at shallow depths. To the southwest, a 2 km Tertiary sedimentary section appears to terminate against a near-vertical fault. The zone between this fault and the San Andreas may be floored at 3 km by flat-lying ultramafics. Lateral velocity inhomogeneities are not accounted for in the migration but, in this case, do not seriously hinder the reconstruction of reflectors

A flat-topped leaky-wave source for phased arrays with reduced scan losses

International audienceThis paper describes the design of a planar Fabry-Perot leaky wave antenna generating a flat-topped radiation pattern. The flat-topped pattern is achieved by exciting various leaky-wave modes between a metallic ground plane and a superstrate. Two configurations for the superstrate structure are proposed and analyzed: i) dielectric layers; ii) impedance sheets. In all cases, the antennas are fed by a small waveguide opening in the ground plane. An in-house optimization tool based on a Green's function spectral approach is used to derive the appropriate arrangement for the generation of the required flat-topped pattern. The proposed approach is validated numerically for an antenna generating a flat topped pattern in an angular range of ±25°. The proposed flat-topped antenna may be used for the design of phased arrays with reduced scan losses over a given angular range

Investment in epilepsy monitoring units improves epilepsy care-experience in a regional neuroscience centre

An evaluation of the clinical yield of inpatient long-term video-EEG (vEEG) in a new epilepsy monitoring unit (EMU) was undertaken, with findings compared to the centre's prior method of bedside vEEG recording in a standard neurology ward, as reported in 2004. A retrospective analysis of neurophysiology reports for all adults who underwent elective vEEG monitoring in the EMU at Cork University Hospital between January 2015 and July 2016 was conducted. Of 115 vEEG studies in the EMU, 100 (87.0%) were deemed diagnostically conclusive, 14 (12.2%) failed to catch any clinical events and showed normal EEG throughout, and one (0.9%) captured spells of unclear clinical significanceâ the corresponding figures reported in 2004 for bedside vEEGs were 21.3%, 77% and 1.6%, respectively. The EMU offers a more effective method of recording inpatient vEEG, which aids decision-making and improves clinical outcomes. Some evidence-based measures which could further enhance diagnostic yield are discussed

Cycles in the chamber homology of GL(3)

Let F be a nonarchimedean local field and let GL(N) = GL(N,F). We prove the existence of parahoric types for GL(N). We construct representative cycles in all the homology classes of the chamber homology of GL(3).Comment: 45 pages. v3: minor correction

The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus.

Filamentous fungi, such as Neurospora crassa, are very efficient in deconstructing plant biomass by the secretion of an arsenal of plant cell wall-degrading enzymes, by remodeling metabolism to accommodate production of secreted enzymes, and by enabling transport and intracellular utilization of plant biomass components. Although a number of enzymes and transcriptional regulators involved in plant biomass utilization have been identified, how filamentous fungi sense and integrate nutritional information encoded in the plant cell wall into a regulatory hierarchy for optimal utilization of complex carbon sources is not understood. Here, we performed transcriptional profiling of N. crassa on 40 different carbon sources, including plant biomass, to provide data on how fungi sense simple to complex carbohydrates. From these data, we identified regulatory factors in N. crassa and characterized one (PDR-2) associated with pectin utilization and one with pectin/hemicellulose utilization (ARA-1). Using in vitro DNA affinity purification sequencing (DAP-seq), we identified direct targets of transcription factors involved in regulating genes encoding plant cell wall-degrading enzymes. In particular, our data clarified the role of the transcription factor VIB-1 in the regulation of genes encoding plant cell wall-degrading enzymes and nutrient scavenging and revealed a major role of the carbon catabolite repressor CRE-1 in regulating the expression of major facilitator transporter genes. These data contribute to a more complete understanding of cross talk between transcription factors and their target genes, which are involved in regulating nutrient sensing and plant biomass utilization on a global level