Grower Perspectives on the Potential Impact of Expanded International Trade of Selected Plants in the U.S. Nursery Industry

Crop Production/Industries, International Relations/Trade,

TIME VARYING PARAMETERS IN THE DEMAND FOR HIGH FRUCTOSE CORN SYRUP

Rapid adoption of high fructose corn syrup and the changing demand for HFCS is measured in a time-varying framework. Demand changes are separated into structural and price competitiveness. Tests for parameter stability are made and simulations based on the estimates are used to show the industry dynamics.Demand and Price Analysis,

Silverman's game on discrete sets

AbstractIn a symmetric Silverman game each of the two players chooses a number from a set S⊂(0,∞). The player with the larger number wins 1, unless the larger is at least T times as large as the other, in which case he loses v. Such games are investigated for discrete S, for T>1 and v>0. Except for v too near zero, where there is a proliferation of cases, explicit solutions are obtained. These are of finite type and, except at certain boundary cases, unique

UNAMBIGUOUS EVALUATIONS OF BIDECIC JACOBI AND JACOBSTHAL SUMS

Abstract For a class of primes p = 1 (mod 20) for which 2 is a quintic nonresidue, unambiguous evaluations of parameters of bidecic Jacobi and Jacobsthal sums (modp

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.

The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthesis and secretion of the cytokine IL-6 from adipocytes and preadipocytes, but not from macrophages. IL-6, in turn, stimulates the phosphorylation of hepatic Stat3 to suppress expression of genes involved in gluconeogenesis, in the process improving glucose handling in obese mice. Preliminary data in a small cohort of obese patients show a similar association. These data support an important role for a subcutaneous adipose tissue-liver axis in mediating the acute metabolic benefits of amlexanox on glucose metabolism, and point to a new therapeutic pathway for type 2 diabetes

Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis *

DNA microarrays are a powerful tool for monitoring thousands of transcript levels simultaneously. However, the use of DNA microarrays in studying the central nervous system faces several challenges. These include the detection of low-abundance transcripts in highly complex tissue as well as estimating relatively low-magnitude changes in transcript levels in response to experimental manipulation. Many transcripts important to brain function have low expression levels or are expressed in relatively few cells, making them difficult to detect in the complex background of brain tissue. The aim of the present study is to evaluate the sensitivity of Gene Chip detection of transcripts in brain by using results from serial analysis of gene expression (SAGE) studies. The results of this comparison indicate that Affymetrix Gene Chips, like SAGE, only reliably detect medium- to high-abundance transcripts and that detection of low-abundance transcripts, many of which have great relevance to biological function in brain, is inconsistent. Specifically, we estimate that Gene Chips reliably detect no more than 30% of the hippocampal transcriptome when using a gross hippocampal dissection as the source tissue. This report provides the first broad evaluation of Affymetrix Gene Chip sensitivity relevant to studying the brain.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75717/1/j.1460-9568.2002.02097.x.pd