The vacuum system of the GANIL beam lines

http://accelconf.web.cern.ch/AccelConf/c84/papers/b36.pdfInternational audienceThe GANIL beam lines are 400 m. long and the average diameter of the pipes is 60 mm. Every fifth meter a beam diagnostic with a high desorption rate is installed. A pressure lower than 10-5 Pascal is required. The method of vacuum calculation, the reasons for the choice of our pumps (turbo molecular and cryogenic) and the results are given

Minor parties and independents in times of change: Scottish local elections 1974 to 2007

This article explores the electoral performance of minor party and Independent candidates in Scottish local elections from 1974 to 2007. This is a period which began with a major restructuring of local government and ended with a change in the electoral system from first-past-the-post to the single transferable vote. It encompasses a second restructuring in the 1990s, the consolidation of the Scottish National Party as an electoral force, and the creation of the Scottish Parliament. Throughout the period, while there have been ebbs and flows, Independents and minor parties have remained significant players in local electoral politics in Scotland

Medication review in preventing older adults\u27 fall-related injury: A systematic review & meta-analysis

Background: Medication review is essential in managing adverse drug reactions and improving drug safety in older adults. This systematic review evaluated medication review\u27s role as a single intervention or combined with other interventions in preventing fall-related injuries in older adults. Methods: Electronic databases search was conducted in PubMed, EMBASE, Scopus, and CINAHL. Two reviewers screened titles and abstracts, reviewed full texts, and performed data extraction and risk of bias assessment. Meta-analyses were conducted on studies with similar participants, interventions, outcomes or settings. Results: Fourteen randomized, controlled studies were included. The pooled results indicated that medication review as a standalone intervention was effective in preventing fall-related injuries in community-dwelling older adults (Risk Difference [RD] = -0.06, 95% CI: [-0.11, -0.00], I2 = 61%, p = .04). Medication review also had a positive impact on decreasing the risk of fall-related fractures (RD = -0.02, 95% CI: [-0.04, -0.01], I2 = 0%, p = .01). Discussion: This systematic review and meta-analysis has demonstrated that medication review is effective in preventing fall-related injuries in general, and fractures specifically, in communitydwelling older adults. Future investigations focusing on the process of performing medication review will further inform fall-related injury prevention for older adults

Assessment of Financial Management Practices of Small and Medium Enterprises (SMEs) in Nasugbu, Batangas

The Small and Medium Enterprises have been identified as important contributors to economic development who are facing a range of challenges which work against their progress, one of which is financial management. This study aimed to assess the financial management practices of small and medium enterprises in Nasugbu, Batangas. The researchers used the descriptive method with a questionnaire as the main instrument in gathering data from 34 respondents. Frequency, percentage, and mean were used as statistical tools in the study, and analysis of variance was used to determine the significant differences between variables. The data gathered were tallied, analyzed and interpreted. The results of the study revealed that majority of the respondents implement financial management practices. Financial management practices such as financial planning, investment, and working capital management are highly applied by small and medium enterprises in Nasugbu, Batangas. It was also revealed that there is a significant difference in the application of financial management practices of small and medium enterprises when they are grouped according to business profile. The outcome of this study may be useful for the entrepreneurs to focus on financial management practices in order to enhance their business performance.

Impairments in error processing and their association with ADHD symptoms in individuals born preterm

<p>(<b>A</b>) Grand average response-locked event-related potentials (ERPs) of the error-related positivity (Pe) at the Cz electrode between 150 and 450 ms for the preterm group (represented by dotted lines), the ADHD group (attention-deficit/hyperactivity disorder represented by dashed lines) and the control group (shown in solid lines), and (<b>B</b>) topographic maps for each group.</p

Counterterrorism in the Philippines: Review of Key Issues

Terrorism has taken root in almost all corners of the world with terrorist organizations thriving in both rich and poor countries. In the Philippines, the Human Security Act of 2007 came into force to address the threat of terrorism to the national security of the country. However, the law has never been fully utilized. To provide law enforcers with a stronger legal measure to address acts of terrorism in the country, President Duterte certified a new Anti-Terrorism Bill as urgent, with Congress adopting the Senate version and approving it in the shortest time possible. Despite opposition from various sectors and growing concerns over some of its provisions, President Duterte signed this into law, officially becoming Republic Act No. 11479 or the Anti-Terrorism Act of 2020. This article briefly reviews some key issues of counterterrorism measures in the Philippines

Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity

The human organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3) are liver-enriched membrane transporters of major importance to hepatic uptake of numerous endogenous compounds, including bile acids, steroid conjugates, hormones, and drugs, including the 3-hydroxy-3- methylglutaryl Co-A reductase inhibitor (statin) family of cholesterol-lowering compounds. Despite their remarkable substrate overlap, there are notable exceptions: in particular, the gastrointestinal peptide hormone cholecystokinin-8 (CCK-8) is a high affinity substrate for OATP1B3 but not OATP1B1. We utilized homologous recombination of linear DNA by E. coli to generate a library of cDNA containing monomer size chimeric OATP1B1-1B3 and OATP1B3-1B1 transporters with randomly distributed chimeric junctions to identify three discrete regions of the transporter involved in conferring CCK-8 transport activity. Site-directed mutagenesis of three key residues in OATP1B1 transmembrane helices 1 and 10, and extracellular loop 6, to the corresponding residues in OATP1B3, resulted in a gain of CCK-8 transport by OATP1B1. The residues appear specific to CCK-8, as the mutations did not affect transport of the shared OATP1B substrate atorvastatin or the OATP1B1-specific substrate estrone sulfate. Regions involved in gain of CCK-8 transport by OATP1B1, when mapped to the crystal structures of bacterial transporters from the major facilitator superfamily, are positioned to suggest these regions could readily interact with drug substrates. Accordingly, our data provide new insight into the molecular determinants of the substrate specificity of these hepatic uptake transporters with relevance to targeted drug design and prediction of drug-drug interactions. © 2012 American Chemical Society

Interreligious dialog to the citizens behaviour of univesitaries students

In the national context, La Araucanía is a region characterized by ethnic, cultural and religious diversity. At the same time, the growing emergence of awareness of identity and belonging to the Mapuche people and the asymmetry of living conditions in relation to the dominant society have made the conflict between the State of Chile and the Mapuche people a topic of first regional relevance. On the other hand, the Catholic University of Temuco, since its foundation in 1959, has declared a clear and determined commitment to the region, seeking to understand and contribute to the solution of its problems, challenges and aspirations. The proposal of this presentation is that, in order to fulfill its public commitment to contribute to social coexistence, UC Temuco must attend to the integral formation of its students as professionals and citizens, one of whose dimensions is the religious worldview, which implies finding and defend the proper status of the 'education of the faith' in the university context, characterized by 'religious neutrality'. In this context, it is proposed to consider the conditions for an authentic interreligious dialogue as the most appropriate perspective to favor the development of the faith in the university environment. In this framework, the case of the elective course Manifestations of spirituality in Araucanía is presented. A look at diversity. Four relevant moments of this experience are described: religious identity, religions before contemporary reality, testimonies of faith, and leaving oneself to meet the other. Finally, some significant results are presented for the purpose of contributing to the formation of citizens committed to harmonious coexistence and peace