Realistic estimation for the detectability of dark matter subhalos using Fermi-LAT catalogs

Numerical simulations of structure formation have made remarkable progress in recent years, in particular due to the inclusion of baryonic physics evolving with the dark matter component. We generate Monte Carlo realizations of the dark matter subhalo population based on the results of the recent hydrodynamical simulation suite of Milky Way–sized galaxies [F. Marinacci, R. Pakmor, and V. Springel, Mon. Not. R. Astron. Soc. 437, 1750 (2014).MNRAA40035-871110.1093/mnras/stt2003]. We then simulate the gamma-ray sky for both the setup of the 3FGL and 2FHL Fermi Large Area Telescope (LAT) catalogs, including the contribution from the annihilation of dark matter in the subhalos. We find that the flux sensitivity threshold strongly depends on the particle dark matter mass and, more mildly, also on its annihilation channel and the observation latitude. The results differ for the 3FGL and 2FHL catalogs, given their different energy thresholds. We also predict that the number of dark matter subhalos among the unassociated sources is very small. A null number of detectable subhalos in the Fermi-LAT 3FGL catalog would imply upper limits on the dark matter annihilation cross section into bb[over ¯] of 2×10^{-26}(5×10^{-25})  cm^{3}/s with M_{DM}=50(1000)  GeV. We find less than one extended subhalo in the Fermi-LAT 3FGL catalog. As a matter of fact, the differences in the spatial and mass distribution of subhalos between hydrodynamic and dark matter–only runs do not have significant impact on the detectability of dark subhalos in gamma rays

Detection of ST1702 Escherichia coli blaNDM-5 and blaCMY-42 genes positive isolates from a Northern Italian hospital

We describe two multi drug-resistant (MDR) carbapenemase-producing Escherichia coli clinical isolates from an acute hospital in Milan. Both strains, isolated from a surgical wound sample and a surveillance rectal swab respectively, were positive for a blaNDM-type gene by Xpert Carba-R test. The whole-genome sequence characterization disclosed several resistance determinants: blaNDM-5, blaCMY-42, blaTEM-198, rmtB, mphA. The two isolates belonged to phylogenetic group A, sequence type (ST) 1702 and serotype O89:H9. PCR-based replicon typing and conjugation assay demonstrated an IncI1 plasmid localization for both blaNDM-5 and blaCMY-42 genes. This is the first report of a ST1702 NDM-5 and CMY-42- producing E. coli clone in Italy

Presence of carbepenemase-producing Enterobacteriaceae in the River Lambro basin, Italy: might sediment represent an important resistance reservoir?

In the last years, the rapid spread in anthropized ecosystems of pathogens which are resistant to carbapenem antibiotics has raised great concern. In this study, KPC-producing Klebsiella pneumoniae was found in the River Lambro in June 2019, whereas KPC-producing Klebsiella oxytoca and Citrobacter braakii were identified in untreated wastewaters. Susceptibility profiles indicated resistance to imipenem, ertapenem and meropenem. Different carbapenamase genes (blaKPC, blaNDM, blaVIM, blaOXA-48) were also found in the River Lambro, although not associated to living bacteria. The presence of a wide set of carbapenemase genes and resistant pathogens show that river sediments could act as a reservoir of antibiotic resistance potentially threatening human health

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2

HADES: a new numerical tool for the determination of DM over-densities

Cosmological simulations predict dark matter to form bound structures (i.e. main halos), hosting galaxies and eventually a population of less massive dark matter over-densities, (i.e. sub-halos). The determination of the spatial dark matter distribution in halos and sub-halos is one major challenge in the analysis of galaxy formation simulations, and usually relies on halo finder algorithms coupled with approximated analytical density profiles. Such determination is crucial for deriving, among others, dark matter signatures in astroparticle observables, e.g. the flux of gamma-ray photons from dark matter particle annihilation. We present here the "Halo Accurate Density Evaluation System" (HADES) a novel numerical tool to reconstruct the dark matter density locally at any point in the simulation volume with high accuracy. We run thorough tests of the code performances on dedicated mock realisations of halos starting from analytical dark matter profile distributions. We show that on mock halos HADES can recover the dark matter density with a few $\%$ accuracy, resolving efficiently all sub-structures containing down to 1000 particles and providing conservative estimates for smaller sub-halos. We illustrate how HADES can be used to compute all-sky maps of the dark matter spatial distribution, squared and integrated along the line of sight, already accounting for the signal boosting coming from density fluctuations. We also present an application of the code to one halo in the TNG50-1-Dark simulation from the IllustrisTNG suite, and highlight how HADES automatically maps out the asymmetries present in the dark matter spatial distribution both in halos and sub-halos, promising to become a helpful tool for a vast number of astrophysical applications

Mimmo Rotella e il Surrealismo: i rimandi all’iconografia surrealista negli oggetti, nei frottages e negli éffaçages

Il volume è pubblicato in occasione del centenario della nascita di Mimmo Rotella, in concomitanza della più ampia mostra mai realizzata sull'artista. Ricco di contributi critici e di un vasto apparato iconografico, il volume ripercorre tutte le tappe della carriera dell'artista, nato a Catanzaro nel 1918: dalle prime opere astratte, alle esperienze informali degli anni '50, dalla relazione con il Nouveau Réalisme di Pierre Restany, alle tangenze con la Pop Art, al rapporto con l'America. Ampio approfondimento è dedicato alla sua ricerca più nota, quella intorno ai décollages e ai retro d'affiches, ma viene anche indagato il rapporto con città come New York, Roma, Parigi e Milano, con la critica d'arte e con gli artisti contemporanei. Completano il volume apparati biobibliografici. testi di: Clare Bell, Tobia Bezzola, Paola Bonani, Ester Coen, Vincenzo De Bellis, Veronica Locatelli, Lola Lorant, Elizabeth Mangini, Gianfranco Maraniello, Massimo Mininni, Luca Pietro Nicoletti, Massimo Romeri, Paul-Louis Roubert, Francesca Pola, Marta Sironi, Antonella Soldaini, Chiara Spangaro, Francesco Tedeschi, Giulia Tulino, Riccardo Ventur

Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume I Introduction to DUNE

International audienceThe preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE's physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology