30 research outputs found
Fluorescein angiography compared to three-dimensional measurements by the retinal thickness analyzer in classic choroidal neovascularization
Purpose: To compare and correlate imaging of classic subfoveal choroidal neovascularization (CNV) with noninvasive 3-dimensional imaging by the retinal thickness analyzer (RTA) to conventional fluorescein angiography (FA). Methods: A total of 29 eyes of 29 consecutive patients with predominantly classic CNV eligible for photodynamic therapy underwent FA and RTA imaging. The FA dimensions of the CNV were measured independently by two graders. With the RTA, masked to FA the size of the CNV itself as imaged in 3-dimensional reconstruction, the size of significantly thickened retina overlying the CNV and the maximum retinal thickness were measured. Results: The mean diameter of the CNV determined from 3-dimensional RTA reconstructions showed an excellent correlation with measurements from FA (r = 0.91, p < 0.001). The area of retinal thickening was by a mean of 0.7 mm in diameter larger and correlated moderately well with the size of the CNV on FA (r = 0.65, p < 0.001). In contrast, there was no correlation between the absolute retinal thickness and the CNV size on FA. Conclusions: Noninvasive quantitative mapping of predominantly classic CNV by RTA is feasible and also allows 3-dimensional measurement of the lesion itself. The results correlate well with FA assessment but visualize different properties of the disease. Copyright (c) 2007 S. Karger AG, Basel
an experimental approach with a trauma film paradigm
Background Intrusive memories of traumatic events are a core feature of post-
traumatic stress disorder but little is known about the neurobiological
formation of intrusions. The aim of this study was to determine whether the
activity of the noradrenergic system during an intrusion-inducing stressor
would influence subsequent intrusive memories. Method We conducted an
experimental, double-blind, placebo-controlled study in 118 healthy women.
Participants received a single dose of either 10 mg yohimbine, stimulating
noradrenergic activity, or 0.15 mg clonidine, inhibiting noradrenergic
activity, or placebo. Subsequently, they watched an established trauma film
which induced intrusions. The number of consecutive intrusions resulting from
the trauma film, the vividness of the intrusions, and the degree of distress
evoked by the intrusions were assessed during the following 4 days. Salivary
cortisol and α-amylase were collected before and after the trauma film.
Results A significant time × treatment interaction for the number of
intrusions and the vividness of intrusions indicated a different time course
of intrusions depending on treatment. Post-hoc tests revealed a delayed
decrease of intrusions and a delayed decrease of intrusion vividness after the
trauma film in the yohimbine group compared with the clonidine and placebo
groups. Furthermore, after yohimbine administration, a significant increase in
salivary cortisol levels was observed during the trauma film. Conclusions Our
findings indicate that pharmacological activation of the noradrenergic system
during an emotionally negative event makes an impact on consecutive intrusive
memories and their vividness in healthy women. The noradrenergic system seems
to be involved in the formation of intrusive memories
Time Savings Using a Digital Workflow versus a Conventional for Intraocular Lens Implantation in a Corporate Chain Hospital Setting [Corrigendum]
Rombold F, Niederdellmann C, Pariti R, Khayat B. Clin Ophthalmol. 2024;18:113-119.
On page 113, Abstract, Results subheading, “The digital cataract workflow resulted in shorter mean (± standard deviation [SD]) preoperative assessments with lesser variability among individual assessments than the existing workflow (14.15 ± 1.86 vs 21.41 ± 1.18 min, respectively); with a time saving of 35%” should have been “The digital cataract workflow resulted in shorter mean (± standard deviation [SD]) preoperative assessments with lesser variability among individual assessments than the existing workflow (14.15 ± 1.18 vs 21.41 ± 2.26 min, respectively); with a time saving of 35%”.
On page 115, Results section, Preoperative Assessments, 2nd paragraph, “The overall mean (±SD) process time for the preoperative assessments was reduced in the digital cataract workflow (14.15 [±1.86] min) compared to the existing conventional workflow (21.41 [±1.18] min) with an overall time saving of approximately 35% (Table 1)” should have been “The overall mean (±SD) process time for the preoperative assessments was reduced in the digital cataract workflow (14.15 [±1.18] min) compared to the existing conventional workflow (21.41 [±2.26] min) with an overall time saving of approximately 35% (Table 1)”.
On page 116, Table 1, Preoperative assessments# row, the standard deviation values in the 3rd and 4th columns were flipped in error, 14.15 ± 1.86 should be 14.15 ± 1.18 and 21.41 ± 1.18 should be 21.41 ± 2.26.
The authors apologize for any inconvenience caused by these errors and for any confusion that may have arisen as a result. They would like to assure the readers that these corrections do not affect the results or conclusions of the paper
Vorhersage des postoperativen Sehvermögens nach Kataraktoperationen mit Hilfe von Machine Learning
Fluorescein angiography compared to three-dimensional measurements by the retinal thickness analyzer in classic choroidal neovascularization
Purpose: To compare and correlate imaging of classic subfoveal choroidal neovascularization (CNV) with noninvasive 3-dimensional imaging by the retinal thickness analyzer (RTA) to conventional fluorescein angiography (FA). Methods: A total of 29 eyes of 29 consecutive patients with predominantly classic CNV eligible for photodynamic therapy underwent FA and RTA imaging. The FA dimensions of the CNV were measured independently by two graders. With the RTA, masked to FA the size of the CNV itself as imaged in 3-dimensional reconstruction, the size of significantly thickened retina overlying the CNV and the maximum retinal thickness were measured. Results: The mean diameter of the CNV determined from 3-dimensional RTA reconstructions showed an excellent correlation with measurements from FA (r = 0.91, p < 0.001). The area of retinal thickening was by a mean of 0.7 mm in diameter larger and correlated moderately well with the size of the CNV on FA (r = 0.65, p < 0.001). In contrast, there was no correlation between the absolute retinal thickness and the CNV size on FA. Conclusions: Noninvasive quantitative mapping of predominantly classic CNV by RTA is feasible and also allows 3-dimensional measurement of the lesion itself. The results correlate well with FA assessment but visualize different properties of the disease. Copyright (c) 2007 S. Karger AG, Basel
Challenging control over emotions in borderline personality disorder: A tDCS study
Background: Deficient cognitive control (CC) over emotional distraction is a central characteristic of borderline personality disorder (BPD). Reduced activation of the left dorsolateral prefrontal cortex (dlPFC) has been linked to this deficit. This study investigates whether it is possible to ameliorate CC deficits via anodal tDCS over the left dlPFC in BPD. Furthermore, we investigate whether the extent of CC impairment influences how well one responds to tDCS. Methods: The effect of a single-session tDCS (1 mA for 20 min, reference electrode on the contralateral mastoid bone) to the left dlPFC (F3) on the CC of patients with BPD (N = 20) and healthy control participants (HCs, N = 20) was examined in a double-blinded, balanced randomized, sham-controlled crossover trial. A delayed response working memory task with negative, neutral and positive pictures presented during the delay period was conducted to assess CC. Stimulation was applied simultaneously with the task. Results: Negative pictures caused prolonged response times as compared to a control condition in patients with BPD and HCs. Anodal tDCS to the left dlPFC did not significantly reduce this interference effect in the overall sample. Further analyses showed, however, that participants with impaired CC profited the most from anodal tDCS. In the subgroup of participants who actually showed an interference effect we found the expected significant amelioration of CC under tDCS. Conclusions: The present study demonstrates that anodal tDCS applied to the left dlPFC improves deficient CC. Thereby, base-level performance moderates tDCS effects. Hence, tDCS might be suitable to support behavioral trainings to enhance CC specifically in people whose impairments in CC are comparably high