Effect of parent concrete on the performance of recycled aggregate concrete

Recycling concrete construction waste is a promising way towards sustainable construction. Indeed, replacing natural aggregates with recycled aggregates obtained from concrete waste lowers the environmental impact of concrete constructions and improves natural resource conservation. This paper reports on an experimental study on mechanical and durability properties of concretes casted with recycled aggregates obtained from two different parent concretes, belonging to two structural elements of the old Cagliari stadium. The effects of parent concretes on coarse recycled aggregates and on new structural concretes produced with different replacement percentages of these recycled aggregates are investigated. Mechanical properties (compressive strength, modulus of elasticity, and splitting tensile strength) and durability properties (water absorption, freeze thaw, and chloride penetration resistance) are experimentally evaluated and analyzed as fundamental features to assess structural concrete behavior. The results show that the mechanical performance of recycled concrete is not related to the parent concrete characteristics. Furthermore, the resistance to pressured water penetration is not reduced by the presence of recycled aggregates, and instead, it happens for the chloride penetration resistance. The resistance to frost–thawing seems not related to the recycled aggregates replacement percentage, while an influence of the parent concrete has been assessed

Fast falling weight deflectometer method for condition assessment of rc bridges

In this paper, the use of Fast Falling Weight Deflectometer (Fast-FWD) is analyzed as a non-destructive and quick test procedure to evaluate the efficiency of short-span bridges. The FastFWD is an instrument that can produce a broadband dynamic force up to an impact value of 120 KN: The impact is constant and replicable, providing accurate action measures of bridge stiffness in a truly short period (30 ms). In this paper, a single-span reinforced concrete bridge is investigated, using the Fast-FWD. The considered bridge, approximately 12.0 m long and 15.5 m wide, was in critical condition. The bridge is in a suburban principal road near to the City of Cagliari in Sardinia (Italy), with an Annual Average Daily Traffic of 13,500 vehicles/day, and was suddenly closed, creating serious problems for urban mobility. In these conditions, the investigation through other standard techniques is time-consuming and labor intensive. For this reason, it is important to introduce methods that can be rapid, accurate and cost-efficient. In this paper, bridge stiffness values obtained during the in situ experimental campaign were compared with finite element models values. The Fast-FWD has the potential to provide engineering information that can help us to better understand bridge condition, in a rapid and cost-effective procedure

An experimental approach for in-situ characterization of dynamic dissipative properties of road pavements

The dissipative properties of road pavements may have beneficial effects to reduce vehicle vibrations, traffic noise, vehicles-structure dynamic interaction, and degradation of pavement materials. Assessing the dissipative capacity and the damping properties of road pavements is, therefore, of critical importance. Such assessment has been mainly conducted in recent years by laboratory-scale dynamic experiments, while little effort has been devoted to insitu tests. The latter are, in fact, cumbersome for practical reasons and typically require a more advanced data analysis when highly coupled modes of vibration are involved. Due to the heterogeneity of the road structure, classical methods are not capable of accurately estimating the road damping properties. The present study proposes an alternative experimental approach based on recording signals from accelerometers embedded in the road, which is impacted by an instrumented hammer. The data are analyzed both in the frequency and in the time domains through the combined use of stabilization diagrams and energy decay tools. Multi-mode fitting algorithms are employed to construct stabilization diagrams for the identification of resonance frequencies, while energy decay curves allow for a robust evaluation of the damping values at the identified frequencies. The effectiveness of the approach was assessed on an asphalt road structure

Harnessing Wharton's jelly stem cell differentiation into bone-like nodule on calcium phosphate substrate without osteoinductive factors.

An important aim of bone regenerative medicine is to design biomaterials with controlled chemical and topographical features to guide stem cell fate towards osteoblasts without addition of specific osteogenic factors. Herein, we find that sprayed bioactive and biocompatible calcium phosphate substrates (CaP) with controlled topography induce, in a well-orchestrated manner, Wharton's jelly stem cells (WJ-SCs) differentiation into osteoblastic lineage without any osteogenic supplements. The resulting WJ-SCs commitment exhibits features of native bone, through the formation of three-dimensional bone-like nodule with osteocyte-like cells embedded into a mineralized type I collagen. To our knowledge, these results present the first observation of a whole differentiation process from stem cell to osteocytes-like on a synthetic material. This suggests a great potential of sprayed CaP and WJ-SCs in bone tissue engineering. These unique features may facilitate the transition from bench to bedside and the development of successful engineered bone.Designing materials to direct stem cell fate has a relevant impact on stem cell biology and provides insights facilitating their clinical application in regenerative medicine. Inspired by natural bone compositions, a friendly automated spray-assisted system was used to build calcium phosphate substrate (CaP). Sprayed biomimetic solutions using mild conditions led to the formation of CaP with controlled physical properties, good bioactivity and biocompatibility. Herein, we show that via optimization of physical properties, CaP substrate induce osteogenic differentiation of Wharton's jelly stem cells (WJ-SCs) without adding osteogenic supplement factors. These results suggest a great potential of sprayed CaP and WJ-SCs in bone tissue engineering and may facilitate the transition from bench to beside and the development of clinically successful engineered bone.journal articleresearch support, non-u.s. gov't2017 022016 11 22importe

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma.

Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal or mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping of multiple cohorts of patients. We show that deep learning can reproduce the diagnosis of HCC vs. CCA with a high performance. We analyze a series of 405 cHCC-CCA patients and demonstrate that the model can reclassify the tumors as HCC or ICCA, and that the predictions are consistent with clinical outcomes, genetic alterations and in situ spatial gene expression profiling. This type of approach could improve treatment decisions and ultimately clinical outcome for patients with rare and biphenotypic cancers such as cHCC-CCA

The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours : Protocol for a systematic review

Background: The aim of this study is to use a systematic review framework to identify and synthesise the evidence on the use of proton beam therapy (PBT) for the treatment of children with CNS tumours and where possible compare this to the use of photon radiotherapy (RT). Methods: Standard systematic review methods aimed at minimising bias will be employed for study identification, selection and data extraction. Twelve electronic databases have been searched, and further citation, hand searching and reference checking will be employed. Studies assessing the effects of PBT used either alone or as part of a multimodality treatment regimen in children with CNS tumours will be included. Relevant economic evaluations will also be identified. The outcomes are survival (overall, progression-free, event-free, disease-free), local and regional control rates, short- and long-term adverse events, functional status measures and quality of survival. Two reviewers will independently screen and select studies for inclusion in the review. All interventional study designs will be eligible for inclusion in the review. However, initial scoping searches indicate the evidence base is likely to be limited to case series studies, with no studies of a higher quality being identified. Quality assessment will be undertaken using pre-specified criteria and tailored to study design if applicable. Studies will be combined using a narrative synthesis, with differences in results between studies highlighted and discussed in relation to the patient population, intervention and study quality. Where appropriate, if no studies of a comparative design are identified, outcomes will be compared against a range of estimates from the literature for similar populations and treatment regimens from the best available evidence from studies that include the use of advanced conventional photon therapy. Discussion: The evidence base for the use of PBT in children with CNS tumours is likely to be relatively sparse, highly heterogeneous and potentially of a low quality with small sample sizes. Furthermore, selection and publication biases may limit the internal and external validity of studies. However, any tentative results from the review on potential treatment effects can be used to plan better quality research studies that are of a design appropriate for outcome comparison with conventional therapy. Systematic review registration: PROSPERO CRD4201502958

“Experimental Investigation on the Use of Recycled Aggregates”

More than 95% of road infrastructures materials consist of aggregates. Highway and construction industries consume annually a huge amount of aggregates, causing considerable energy and environmental losses. The aim of this research is to evaluate the suitability of construction and demolition waste (C&DW) materials, produced in Sardinia (Italy), from the physical and mechanical point of view. Laboratory tests were conducted to evaluate physical characteristics and also an experimental road has been built to evaluate mechanical performances in situ. The research has been divided in two main phases: in the first phase laboratory tests were carried out such as Sieve analysis, Limits of Atterberg, CBR test, L.A. abrasion test. In the second phase in situ tests were carried out consisting of: dry density of soil by sand replacement method and both static and dynamic plate tests. Other tests were carried out to study the behaviour of the material during its use (short term behaviour and in the long term), in order to evaluate environmental compatibility of the material in place under working conditions, as well as the mechanical performance in situ or in a real scale test. The first results are encouraging, the material is non-plastic, the Los Angeles abrasion test shows the tendency to fragmentation of the aggregates, but within the limits, therefore allowing their use in road sub-grade layer also the material shows good bearing capacity. The introduction in the market for the construction of roads of solid waste materials helps to limit the exploitation of renewable natural resources

EXPERIMENTAL INVESTIGATION ON THE USE OF C&DW MATERIALS AS AGGREGATES FOR ROAD SUB-BASE

More than 95% of road infrastructures materials consist of aggregates. Highway and construction industries consume annually a huge amount of aggregates, causing considerable energy and environmental losses (Hüseyin et al, 2007). Many country are substituting quarry aggregates with construction and demolition waste (C&DW) materials. However in Italy there is the need to overcome the distrust for the use of C&D materials. Thus, the aim of this research is to evaluate the suitability of construction and demolition waste (C&DW) materials, produced in Sardinia (Italy), from the physical and mechanical point of view. Laboratory tests were conducted to evaluate physical characteristics and also an experimental road has been built to evaluate mechanical performances in situ. The research has been divided in two main phases: in the first phase laboratory tests were carried out such as Sieve analysis, Limits of Atterberg, CBR test, L.A. abrasion test. In the second phase in situ tests were carried out consisting of: dry density of soil by sand replacement method and both static and dynamic plate tests. Other tests were carried out to study the behaviour of the material during its use (short term behaviour and in the long term), in order to evaluate environmental compatibility of the material in place under working conditions, as well as the mechanical performance in situ or in a real scale test. The first results are encouraging, the material is non-plastic, the Los Angeles abrasion test shows the tendency to fragmentation of the aggregates, but within the limits, therefore allowing their use in road sub-grade layer also the material shows good bearing capacity. The introduction in the market for the construction of roads of solid waste materials helps to limit the exploitation of renewable natural resources