18,502 research outputs found
Role of the particle's stepping cycle in an asymmetric exclusion process: A model of mRNA translation
Messenger RNA translation is often studied by means of statistical-mechanical
models based on the Asymmetric Simple Exclusion Process (ASEP), which considers
hopping particles (the ribosomes) on a lattice (the polynucleotide chain). In
this work we extend this class of models and consider the two fundamental steps
of the ribosome's biochemical cycle following a coarse-grained perspective. In
order to achieve a better understanding of the underlying biological processes
and compare the theoretical predictions with experimental results, we provide a
description lying between the minimal ASEP-like models and the more detailed
models, which are analytically hard to treat. We use a mean-field approach to
study the dynamics of particles associated with an internal stepping cycle. In
this framework it is possible to characterize analytically different phases of
the system (high density, low density or maximal current phase). Crucially, we
show that the transitions between these different phases occur at different
parameter values than the equivalent transitions in a standard ASEP, indicating
the importance of including the two fundamental steps of the ribosome's
biochemical cycle into the model.Comment: 9 pages, 9 figure
The boson-fermion model: An exact diagonalization study
The main features of a generic boson-fermion scenario for electron pairing in
a many-body correlated fermionic system are: i) a cross-over from a poor metal
to an insulator and finally a superconductor as the temperature decreases, ii)
the build-up of a finite amplitude of local electron pairing below a certain
temperature , followed by the onset of long-range phase correlations among
electron pairs below a second characteristic temperature , iii) the
opening of a pseudogap in the DOS of the electrons below , rendering these
electrons poorer and poorer quasi-particles as the temperature decreases, with
the electron transport becoming ensured by electron pairs rather than by
individual electrons. A number of these features have been so far obtained on
the basis of different many-body techniques, all of which have their built-in
shortcomings in the intermediate coupling regime, which is of interest here. In
order to substantiate these features, we investigate them on the basis of an
exact diagonalization study on rings up to eight sites. Particular emphasis has
been put on the possibility of having persistent currents in mesoscopic rings
tracking the change-over from single- to two-particle transport as the
temperature decreases and the superconducting state is approached.Comment: 7 pages, 8 figures; to be published in Phys. Rev.
Ribosome recycling induces optimal translation rate at low ribosomal availability
Funding statement The authors thank BBSRC (BB/F00513/X1, BB/I020926/1 and DTG) and SULSA for funding. Acknowledgement The authors thank R. Allen, L. Ciandrini, B. Gorgoni and P. Greulich for very helpful discussions and careful reading of the manuscript.Peer reviewedPublisher PD
Control of spin relaxation in semiconductor double quantum dots
We propose a scheme to manipulate the spin relaxation in vertically coupled
semiconductor double quantum dots. Up to {\em twelve} orders of magnitude
variation of the spin relaxation time can be achieved by a small gate voltage
applied vertically on the double dot. Different effects such as the dot size,
barrier height, inter-dot distance, and magnetic field on the spin relaxation
are investigated in detail. The condition to achieve a large variation is
discussed.Comment: 5 pages, 4 figures, to be published in PR
Teleportation is necessary for faithful quantum state transfer through noisy channels of maximal rank
Quantum teleportation enables deterministic and faithful transmission of
quantum states, provided a maximally entangled state is pre-shared between
sender and receiver, and a one-way classical channel is available. Here, we
prove that these resources are not only sufficient, but also necessary, for
deterministically and faithfully sending quantum states through any fixed noisy
channel of maximal rank, when a single use of the cannel is admitted. In other
words, for this family of channels, there are no other protocols, based on
different (and possibly cheaper) sets of resources, capable of replacing
quantum teleportation.Comment: 4 pages, comments are welcom
Hospital environment as a reservoir for cross transmission. Cleaning and disinfection procedures
Background. Healthcare associated infections (HAIs) represent a serious problem for public health, as they increase the morbidity and mortality rates, present a relevant financial burden, and significantly contribute to the antimicrobial resistance. Methods. The aim of this review was to investigate the literature about HAIs, with particular reference to hospital environments and the role of cleaning and disinfection procedures. Hospital environments are an essential reservoir for HAIs cross transmission, and the application of appropriate procedures related to hand hygiene and disinfection/sterilization of surfaces and instruments remain key strategies for controlling HAIs. Results. Different procedures, based on the risk associated with the healthcare procedure, are recommended for hand hygiene: washing with soap and water, antiseptic rubbing with alcohol-based disinfectants, antiseptic and surgical hand washing. Environmental surfaces can be treated with different products, and the mostly used are chlorine-based and polyphenolic disinfectant. The reprocessing of instruments is related to their use according to the Spaulding's classification. In addition, scientific evidence demonstrated the great relevance of the "bundles" (small set of practices performed together) in controlling HAIs. Conclusions. Research agenda should include the improvement of well-known effective preventive procedures and the development of new bundles devoted to high-risk procedures and specific microorganisms
The accretion environment of Supergiant Fast X-ray Transients probed with XMM-Newton
Supergiant fast X-ray transients (SFXTs) are characterized by a remarkable
variability in the X-ray domain, widely ascribed to the accretion from a clumpy
stellar wind. In this paper we performed a systematic and homogeneous analysis
of sufficiently bright X-ray flares from the SFXTs observed with XMM-Newton to
probe spectral variations on timescales as short as a few hundred of seconds.
Our ultimate goal is to investigate if SFXT flares and outbursts are triggered
by the presence of clumps and eventually reveal whether strongly or mildly
dense clumps are required. For all sources, we employ a technique developed by
our group, making use of an adaptive rebinned hardness ratio to optimally
select the time intervals for the spectral extraction. A total of twelve
observations performed in the direction of five SFXTs are reported. We show
that both strongly and mildly dense clumps can trigger these events. In the
former case, the local absorption column density may increase by a factor of
>>3, while in the latter case, the increase is only by a factor of 2-3 (or
lower). Overall, there seems to be no obvious correlation between the dynamic
ranges in the X-ray fluxes and absorption column densities in SFXTs, with an
indication that lower densities are recorded at the highest fluxes. This can be
explained by the presence of accretion inhibition mechanism(s). We propose a
classification of the flares/outbursts from these sources to drive future
observational investigations. We suggest that the difference between the
classes of flares/outbursts is related to the fact that the mechanism(s)
inhibiting accretion can be overcome more easily in some sources compared to
others. We also investigate the possibility that different stellar wind
structures, rather than clumps, could provide the means to temporarily overcome
the inhibition of accretion in SFXTs.Comment: Accepted for publication on A&
Effect of grain refinement on enhancing critical current density and upper critical field in undoped MgB2 ex-situ tapes
Ex-situ Powder-In-Tube MgB2 tapes prepared with ball-milled, undoped powders
showed a strong enhancement of the irreversibility field H*, the upper critical
field Hc2 and the critical current density Jc(H) together with the suppression
of the anisotropy of all of these quantities. Jc reached 104 A/cm2 at 4.2 K and
10 T, with an irreversibility field of about 14 T at 4.2 K, and Hc2 of 9 T at
25 K, high values for not-doped MgB2. The enhanced Jc and H* values are
associated with significant grain refinement produced by milling of the MgB2
powder, which enhances grain boundary pinning, although at the same time also
reducing the connectivity from about 12% to 8%. Although enhanced pinning and
diminished connectivity are in opposition, the overall influence of ball
milling on Jc is positive because the increased density of grains with a size
comparable with the mean free path produces strong electron scattering that
substantially increases Hc2, especially Hc2 perpendicular to the Mg and B
planes.Comment: 26 pages, 9 figures, submitted to J. Appl. Phy
Swift J1734.5-3027: a new long type-I X-ray bursting source
Swift J1734.5-3027 is a hard X-ray transient discovered by Swift while
undergoing an outburst in September 2013. Archival observations showed that
this source underwent a previous episode of enhanced X-ray activity in May-June
2013. In this paper we report on the analysis of all X-ray data collected
during the outburst in September 2013, the first that could be intensively
followed-up by several X-ray facilities. Our data-set includes INTEGRAL, Swift,
and XMM-Newton observations. From the timing and spectral analysis of these
observations, we show that a long type-I X-ray burst took place during the
source outburst, making Swift J1734.5-3027 a new member of the class of
bursting neutron star low-mass X-ray binaries. The burst lasted for about 1.9
ks and reached a peak flux of (6.01.8)10 erg cm
s in the 0.5-100 keV energy range. The estimated burst fluence in the
same energy range is (1.100.10)10 erg cm. By
assuming that a photospheric radius expansion took place during the first
200 s of the burst and that the accreted material was predominantly
composed by He, we derived a distance to the source of 7.21.5 kpc.Comment: Accepted for publication on A&
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