La psicología cubana y la salud de los trabajadores : entre el malestar y el bienestar

El artículo tiene como objetivo comunicar el origen y la evolución de la aplicación de la ciencia psicológica al campo multidisciplinario de la salud ocupacional en Cuba. Se tienen en cuenta diversos factores en este proceso : el contexto social y socio-laboral, con una exposición relativamente extensa dada la singularidad del sistema social cubano. La trayectoria de la salud ocupacional en el país y su situación actual crítica. Las aportaciones de la práctica profesional de los psicólogos de la salud en los escenarios laborales que dieron origen a la psicología de la salud ocupacional como una línea de trabajo en la investigación, la docencia y la práctica profesional. Se enfatiza la necesidad de desarrollar trabajos teóricos y metodológicos en esa área desde un punto de vista psicodinámico, que tenga en cuenta la subjetividad, para la que se propone el enfoque histórico cultural de L. S. Vygotsky.O artigo tem como objetivo comunicar a origem e a evolução da aplicação da ciência psicológica ao campo multidisciplinar da saúde ocupacional em Cuba. Vários fatores são levados em consideração nesse processo : O contexto social e sócio-laboral, com uma exposição relativamente extensa, dada a singularidade do sistema social cubano. A trajetória da saúde ocupacional no país e sua situação atual crítica. As contribuições da prática profissional dos psicólogos em cenários de trabalho, que deram origem à psicologia da saúde ocupacional como uma linha de trabalho em pesquisa, ensino e prática profissional. Enfatiza a necessidade de desenvolver trabalhos teóricos e metodológicos nessa área do ponto de vista psicodinâmico, que leva em conta a subjetividade, para a qual é proposta a abordagem histórica cultural de L. S. Vygotsky.L'article veut exposer l'origine et l'évolution de l'application de la science psychologique au domaine multidisciplinaire de la santé au travail à Cuba. Plusieurs facteurs sont pris en compte dans ce processus : le contexte social et socio-professionnel, qui exige un exposé développé compte tenu du caractère singulier du système social cubain ; la trajectoire de la question de la santé au travail dans le pays et sa situation critique actuelle ; les contributions de la pratique professionnelle des psychologues dans les scénarios de travail, qui sont à la source de la psychologie de la santé au travail en tant que domaine d'activité de recherche, d'enseignement et de pratique professionnelle. On souligne la nécessité de développer des travaux théoriques et méthodologiques dans ce domaine, sous un point de vue psychodynamique qui prenne en compte la subjectivité. L'approche culturelle et historique de L. S. Vygotsky est alors proposée.The paper aims at communicating the origin and evolution of the application of psychological science to the multidisciplinary field of occupational health in Cuba. Several factors are taken into account in this process : the social and socio-labor context, with a relatively extensive exposure, given the uniqueness of the Cuban social system. The trajectory of occupational health in the country and its current critical situation. The contributions of the professional practice of psychologists in work scenarios, which gave rise to occupational health psychology as a line of work in research, teaching and professional practice. It emphasizes the need to develop theoretical and methodological work in this area from a psychodynamic point of view, which takes subjectivity into account, for which the cultural historical approach of L. S. Vygotsky is proposed

Synthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lines

With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC1, (1), 4-phenyl-1- (5 -phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human tumor cell lines have revealed that the palladium(II) complexes 5– 8 are more cytotoxic (IC50 values in the range of 0.21 – 3.79 µM) than their corresponding ligands (1 – 4) (> 60 µM). These results indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 = 0.21 µM)

Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2'-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3'-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2'-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1'-nitro-2'-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (–9.87¿M) exhibited higher antiproliferative activity than their free ligands (–70.86 and >250¿M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02¿M, resp.)

18 años de gobiernos panistas en Jalisco: siete ensayos académicos

Tras seis décadas de que el Partido Revolucionario Institucional (PRI) gobernó a México como partido hegemónico, la democratización en el país ha sido objeto de estudio en distintos niveles. Este proceso comenzó en los gobiernos locales, pero aún es reducido el número de investigaciones que documentan la evolución en este plano. Esta obra aborda el caso de Jalisco, uno de los primeros estados en donde el PRI cedió el poder. Aconteció en 1995, cuando perdió la gubernatura frente al Partido Acción Nacional (PAN), que la retuvo por 18 años, para luego cederla de nuevo al partido tricolor. Lo acontecido en estos tres sexenios se reconstruye a través de siete ensayos, en los que se presentan las características de los gobiernos panistas y los avances y retrocesos en la entidad durante las administraciones blanquiazules en el ámbito económico y social, en materia de control y trasparencia de la información, así como de su relación con la prensa y con la sociedad civil. La transición política en Jalisco se repitió a escala federal, por lo que la lectura de los textos que conforman esta obra contribuye a entender mejor el complejo fenómeno de la democratización en México.ITESO, A.C

Characterization of nosocomial infections

Introducción: las infecciones nosocomiales constituyen  un importante  problema de salud  relacionado con la calidad de la atención y la eficacia del trabajo.Objetivo: diseñar una estrategia para mejorar el manejo de las infecciones nosocomiales en el Hospital Pediátrico Provincial Docente “Pepe Portilla” durante el período 2010-2011.Material y método: se realizó una investigación descriptiva, transversal y de intervención. El universo estuvo conformado por los 22652 egresos y la muestra por los 516 casos. Para la obtención de la información se revisaron los registros del departamento de estadística y las historias clínicas, utilizándose para su análisis las frecuencias absolutas, relativas porcentuales y la prueba de X2 al 95 % de certeza. Resultados: el sistema respiratorio es el sitio de mayor localización, donde predominaron los hemocultivos negativos. Los gérmenes  más aislados independientemente de la clasificación de la infección nosocomial fueron: el Staphylococcus epidermidis, la Pseudomonas sp y el Acinetobacter, entre otros. Conclusiones: se elabora una estrategia de intervención que permitirá elevar la competencia y desempeño del personal de salud en el manejo de las infecciones nosocomiales.     Introduction: nosocomial infections constitute an important problem related to the quality and efficiency of the health services. Objective: to characterize nosocomial infections at “Pepe Portilla” Provincial Children Hospital during 2010-2011. Material and method: an observational, descriptive, cross-sectional and applied research was conducted, which target group was comprised of 22652 patients discharged from the hospital and the sample included 516 patients. To collect the information, the records of the statistics department and the clinical histories were reviewed; where absolute frequencies and relative percentages plus chi square test up to 95% of certainty were used to complete its analysis. Results: respiratory tract was the most affected site, where negative hemocultures prevailed. Staphylococcus epidermidis, Pseudomonas sp and Acinetobacter germs were the most isolated, among others. Conclusions: nosocomial infections constitute a health problem in paediatrics, which requires the strengthening of prevention and control activities, emphasizing on its systemic surveillance

Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas

Oral melanomas have some histopathological resemblance with its cutaneous counterpart; however, an aggressive behavior is more common in tumors that occur in the oral cavity. Several markers have been suggested as indicative of tumoral progression and aggressiveness, such as cyclooxygenase 2 (COX-2) and Ki67. In this study, we have compared the expression of COX-2 and Ki67 in a series of amelanotic (n=7) and melanotic oral melanomas (n=22). The cases were selected from 4 pathology laboratories and submitted to the immunohistochemical (IHC) reactions. We analyzed the IHC staining based on a qualitative ? using visual scores; and a computer-assisted method (quantitative) using scanned slides and software for digital analysis. COX-2 was expressed in all oral melanomas; however, its intensity was significantly higher in the amelanotic ones (P<0.001). Similarly, a high Ki67-positivity index was observed in the amelanotic than melanotic ones (P<0.001). Based on these results, we suggest that amelanotic oral melanomas have marked pro-inflammatory and high-proliferative phenotype, justifying their more aggressive behavior compared with the melanotic ones

Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses

Background and Objectives: Fetal growth restriction (FGR) is a severe obstetric disease characterized by a low fetal size entailing a set of undesired consequences. For instance, previous studies have noticed a worrisome association between FGR with an abnormal neurodevelopment. However, the precise link between FGR and neurodevelopmental alterations are not yet fully understood yet. Brain-derived neurotrophic factor (BDNF) is a critical neurotrophin strongly implicated in neurodevelopmental and other neurological processes. In addition, serum levels of BDNF appears to be an interesting indicator of pathological pregnancies, being correlated with the neonatal brain levels. Therefore, the aim of this study is to analyze the blood levels of BDNF in the cord blood from fetuses with FGR in comparison to those with weight appropriate for gestational age (AGA). Materials and Methods: In this study, 130 subjects were recruited: 91 in group A (AGA fetuses); 39 in group B (16 FGR fetuses with exclusively middle cerebral artery (MCA) pulsatility index (PI) 95th percentile). Serum levels of BDNF were determined through ELISA reactions in these groups. Results: Our results show a significant decrease in cord blood levels of BDNF in FGR and more prominently in those with UA PI >95th percentile in comparison to AGA. FGR fetuses with exclusively decreased MCA PI below the 5th percentile also show reduced levels of BDNF than AGA, although this difference was not statistically significant. Conclusions: Overall, our study reports a potential pathophysiological link between reduced levels of BDNF and neurodevelopmental alterations in fetuses with FGR. However, further studies should be conducted in those FGR subjects with MCA PI < 5th percentile in order to understand the possible implications of BDNF in this group.Depto. de Salud Pública y Materno - InfantilFac. de MedicinaTRUEUnión EuropeaComunidad de MadridInstituto de Salud Carlos IIIHalekulani S.LFundación Santiago Dexeus Fontpu

Casos de brucelosis canina presentados en la provincia de Pichincha, Ecuador

La brucelosis canina, ampliamente distribuida en el mundo y con reportes de seroprevalencia de entre 6 % a 35 %, es considerada un problema de salud pública. Esta infección es producida por cuatro de las trece especies del género Brucella: B. canis, B. abortus, B. melitensis y B. suis, dependiendo de la cepa circulante en el área geográfica de estudio. El contagio ocurre principalmente por ingestión, inhalación o contacto con fetos abortados, placenta, secreciones vaginales o semen y también por vía transmamaria y placentaria. La aparición de casos de brucelosis canina marcó el inicio de este estudio con el análisis de la enfermedad mediante identificación del agente causal en dos escenarios epidemiológicos diferentes. En el primer escenario (2008), se tomaron sueros de 151 caninos de 34 fincas de la provincia de Pichincha (Ecuador), que se analizaron para detección de anticuerpos contra cepas lisas mediante Rosa de Bengala, sero-aglutinación lenta en tubo (SAT-EDTA) y ELISA indirecto. En el segundo escenario (2017 a 2019) y utilizando el Rapid test kit (C. Bru Ab Test) para detección de anticuerpos contra cepas rugosas, se analizaron diez sueros de caninos provenientes de clínicas veterinarias de la provincia de Pichincha (Ecuador). Para ambos escenarios se realizó biotipificación y genotipificación.Trabajo publicado en Cagliada, Maria del Pilar Lilia y Galosi, Cecilia Mónica (comps.). I Congreso de Microbiología Veterinaria. Libro de resúmenes. La Plata: Facultad de Ciencias Veterinarias, 2021.Facultad de Ciencias Veterinaria

Influence of Cerebral Vasodilation on Blood Reelin Levels in Growth Restricted Fetuses

Fetal growth restriction (FGR) is one of the most important obstetric pathologies. It is frequently caused by placental insufficiency. Previous studies have shown a relationship between FGR and impaired new-born neurodevelopment, although the molecular mechanisms involved in this association have not yet been completely clarified. Reelin is an extracellular matrix glycoprotein involved in development of neocortex, hippocampus, cerebellum and spinal cord. Reelin has been demonstrated to play a key role in regulating perinatal neurodevelopment and to contribute to the emergence and development of various psychiatric pathologies, and its levels are highly influenced by pathological conditions of hypoxia. The purpose of this article is to study whether reelin levels in new-borns vary as a function of severity of fetal growth restriction by gestational age and sex. We sub-grouped fetuses in: normal weight group (Group 1, n = 17), FGR group with normal umbilical artery Doppler and cerebral redistribution at middle cerebral artery Doppler (Group 2, n = 9), and FGR with abnormal umbilical artery Doppler (Group 3, n = 8). Our results show a significant association of elevated Reelin levels in FGR fetuses with cerebral blood redistribution compared to the normal weight group and the FGR with abnormal umbilical artery group. Future research should focus on further expanding the knowledge of the relationship of reelin and its regulated products with neurodevelopment impairment in new-borns with FGR and should include larger and more homogeneous samples and the combined use of different in vivo techniques in neonates with impaired growth during their different adaptive phases