171 research outputs found
Focal High Intensity Focused Ultrasound for Prostate Cancer
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Long term extension of a randomised controlled trial of probiotics using electronic health records
Get PDFMost randomised controlled trials (RCTs) are relatively short term and, due to costs and available resources, have limited opportunity to be re-visited or extended. There is no guarantee that effects of treatments remain unchanged beyond the study. Here, we illustrate the feasibility, benefits and cost-effectiveness of enriching standard trial design with electronic follow up. We completed a 5-year electronic follow up of a RCT investigating the impact of probiotics on asthma and eczema in children born 2005-2007, with traditional fieldwork follow up to two years. Participants and trial outcomes were identified and analysed after five years using secure, routine, anonymised, person-based electronic health service databanks. At two years, we identified 93% of participants and compared fieldwork with electronic health records, highlighting areas of agreement and disagreement. Retention of children from lower socio-economic groups was improved, reducing volunteer bias. At 5 years we identified a reduced 82% of participants. These data allowed the trial's first robust analysis of asthma endpoints. We found no indication that probiotic supplementation to pregnant mothers and infants protected against asthma or eczema at 5 years. Continued longer-term follow up is technically straightforward
LES CONSEQUENCES PHYSIOLOGIQUES DE L'INTERPOSITION DE SEGMENTS DIGESTIFS DANS LA VOIE URINAIRE
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Report: anatomy, histology and physiology of the intestinal segments involved in urinary entero-cystoplasty
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La place de la laparoscopie dans l'approche invasive minimale en chirurgie urologique.
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