First Description of a Primitive Neuroectodermal Tumor Arising in the Nose

We report the case of a 12-year-old girl, who consulted us with one-year history of an 8 mm nose lesion that was painless and firm upon palpation. The lesion was resected conservatively. Immunohistochemistry was in favor of a primitive neuroectodermal tumor (PNET)/Ewing’s sarcoma lesion, excluding epithelial, lymphoid, and other tumors. After a second resection, our patient was referred to chemotherapy and has already undergone 9 cycles out of 14. The patient is to date with no evidence of persistent or recurrent disease. To our knowledge, this is the first description of a PNET arising in the nose

Painful white plaques of the folds revealing papular acantholytic dyskeratosis

Papular acantholytic dyskeratosis (PAD) is a challenging diagnosis for both dermatologist and pathologist. It predominantly affects female patients, but men can present less frequently the disease. Histopathology is required to confirm the diagnosis and to exclude other acantholytic dermatoses. We present a rare case of PAD in a young male patient, diagnosed by histopathology, and responded well to oral retinoids

Eccentric training effects for patients with post-stroke hemiparesis on strength and speed gait: A randomized controlled trial

International audienceBACKGROUND: In hemiparetic patients, the skeletal muscle is mainly affected with a combination of abnormalities (denervation, remodeling, spasticity, and eventually muscular atrophy). OBJECTIVE: This study examined the role of eccentric exercise in strengthening muscles of the lower extremity and ultimately improving autonomy in patients with post-stroke hemiparesis during gait. METHODS: Thirty-seven patients hemiparetic adults were recruited, randomized into a control group (n = 19) and an intervention group receiving eccentric muscle strengthening (n = 18). The protocol consisted of three sets of five repetitions of eccentric contraction of the paretic limb after determining the maximum repetition (1 MRI). Evaluation of the 1RM, 10 meters and 6WMT was performed before and after the exercise for each group. Manova test was used to compare the differences between the control and intervention groups. RESULTS: The paretic limb showed significant increase in one-repetition maximum (1RM) between before and after rehabilitation (p≤0.00003). The two groups of Patients increased their walking speed (p≤0.0005), but we observed a significant difference between groups only for the 6MWT and not on the 10 meters Test. CONCLUSIONS: Eccentric training can be useful in strengthening the muscles of the lower limbs, and promoting gait performance. Eccentric training could complement other methods of managing patients with post-stroke hemiparesis

Iron Supplementation May Improve the Patient’s Level of Satisfaction in Not-Low-Ferritin Telogen Effluvium: A Real-Life Observational Study

Background: Telogen effluvium (TE) is the most common cause of alopecia in women. Treatment should address the etiological factors and may include adjuvant therapies. In practice, physicians may employ modified approaches and utilize various combinations of topical and oral molecules. Aims: In this real-life observational study, the aim was to evaluate the response of TE to iron supplementation. Materials and Methods: The population consisted of all patients who sought consultation for TE at our dermatology department between March 2021 and February 2022. Eligible participants were women, aged between 18 and 65, having a clinical diagnosis of TE, and intended for treatment with iron supplementation. Exclusion criteria comprised current pregnancy, chronic or active inflammatory disease, newly discovered dysthyroidism, concurrent use of hair supplements, topical minoxidil, or any other medications. The response was assessed based on the patient’s level of satisfaction, a significant indicator, given the substantial psychological impact of TE on women’s daily lives. Results: The analysis included 200 women. The average age was 32.9 ± 11.4 years. A recent history of COVID-19 or treated dysthyroidism was present in 18.5% and 8% of patients, respectively, but did not impact their response. Significantly, patients with baseline ferritin ≥50 ng/ml were mostly “very satisfied”, those with baseline ferritin <50 ng/ml were mostly “not satisfied”, and those with unknown levels were mostly “partially satisfied” with iron supplementation. A high dose of elemental iron and a prolonged duration of treatment significantly improved the patients’ level of satisfaction. Conclusion: Iron supplementation can improve the patient’s level of satisfaction in TE even if serum ferritin is not low

Pediatric epidemiology of skin disorders in a mediterranean population with a nonreferral-based health-care system: A retrospective large series analysis

Introduction: Data from the Levant regarding pediatric dermatoses are limited. The objective was to estimate the prevalence of pediatric dermatoses in a health-care system that allows every patient to directly reach a specialist. Patients and Methods: It is a single-center, chart review, epidemiological study of patients who consulted, between 2010 and 2022, at the general dermatology department of a tertiary care university hospital. A random draw of 10% of the files was screened. Patients aged between 0 and 18 years at the time of consultation were included and their files were analyzed. Results: The study population consisted of 151,050 files, of which 10% were manually screened. Finally, 2313 “pediatric” files were analyzed, corresponding to 15.3% of the sample, with a female-to-male ratio of 1281/1032 (1.24). Of these analyzed files, 2912 diagnoses were distributed in the age categories as follows: 464 (16%) at preschool age, 1134 (39%) at school age, and 1314 (45%) at adolescence. The most prevalent diagnoses in males were acne (19.6%), atopic dermatitis (9.7%), and molluscum contagiosum (8.1%); in females, acne (27.4%), atopic dermatitis (9.4%), and warts (5.8%). Acne was the most frequent diagnosis overall (24%) and in the adolescents' subgroup, with a female-to-male ratio of 1.77. The prevalence of atopic dermatitis decreased from 21.1% at preschool age to 10.9% at school age to 4.3% in adolescence. The most prevalent diagnoses at school age were molluscum contagiosum and warts. Conclusion: These updated percentages help configure suitable public health strategies for children in countries of approximate genetic background and similar life habits

hMZF-2, the Elusive Transcription Factor

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