Boosting Higgs pair production in the bbˉbbˉb\bar{b}b\bar{b} final state with multivariate techniques

The measurement of Higgs pair production will be a cornerstone of the LHC program in the coming years. Double Higgs production provides a crucial window upon the mechanism of electroweak symmetry breaking and has a unique sensitivity to the Higgs trilinear coupling. We study the feasibility of a measurement of Higgs pair production in the $b\bar{b}b\bar{b}$ final state at the LHC. Our analysis is based on a combination of traditional cut-based methods with state-of-the-art multivariate techniques. We account for all relevant backgrounds, including the contributions from light and charm jet mis-identification, which are ultimately comparable in size to the irreducible $4b$ QCD background. We demonstrate the robustness of our analysis strategy in a high pileup environment. For an integrated luminosity of $\mathcal{L}=3$ ab$^{-1}$, a signal significance of $S/\sqrt{B}\simeq 3$ is obtained, indicating that the $b\bar{b}b\bar{b}$ final state alone could allow for the observation of double Higgs production at the High-Luminosity LHC.Comment: 47 pages, 22 figures. v2: updated references, added comparison of post-MVA kinematic distributions. v3: matches published version in EPJ

Creación del área de Coordinación de Rendición de Cuentas, normativa y procesos administrativos internos para la ejecución de la rendición de cuentas para programas con financiamiento específico

Las experiencias académicas y territoriales adquiridas a lo largo del transcurso de la carrera, que direccionaron y moldearon trabajos previos, dieron lugar a la creación de este proyecto de intervención. La elección de la propuesta surge de la necesidad observada en las prácticas tutoriadas sumadas a la labor diaria, dentro del ámbito de la Secretaría Privada de la Secretaría Económica de la UNVM y tiene por finalidad generar un valor agregado a un procedimiento de significativa importancia dentro de la institución. Este documento pretende fortalecer la comprensión de los principios de la administración pública, como la transparencia, eficiencia, eficacia, ética y honradez entre otros, en el control y manejo de fondos públicos. Por su parte, el Plan Estratégico Institucional (PEI) de la Universidad Nacional de Villa María demandó la puesta en funcionamiento de una serie de acciones que evidenciaron la necesidad de mejoras en determinados procesos que se llevan a cabo, más en un área dedicada al control y manejo del presupuesto. Es la propuesta de este Informe Final la creación de normativa y procedimientos administrativos internos, como también la posibilidad de un departamento de coordinación, acorde a las tareas que se realizan para llevar a cabo las rendiciones de cuentas correspondientes a los contratos, convenios, proyectos o cualquier acuerdo que necesite de la rendición de cuenta para su finalidad, que la Institución firma con determinados organismos.Fil: Rojo, María Daniela. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina

Main abbreviations when administering drugs in the UK

A la hora de incorporarse como enfermero a cualquiera de los hospitales del NHS o sistema de salud británico, los enfermeros españoles nos encontramos con bastantes dificultades a la hora de prestar unos cuidados enfermeros de calidad, ya que la enfermería en Inglaterra es muy diferente a la que desarrollamos en España. Una de las mayores dificultades que encontramos es la barrera del idioma, la cual se acentúa cuando nos encontramos con abreviaturas médicas del Inglés, con lo que mediante esta guía se pretende facilitar el trabajo de los enfermeros que se inician en esta experiencia.When incorporated as a nurse to any NHS hospitals or British health system, Spanish nurses we met many difficulties in providing a nursing care quality, since nursing in England it is very different from the we developed in Spain. One of the biggest difficulties we face is the language barrier, which is accentuated when we find English medical abbreviations, which by this guide is to facilitate the work of nurses who are new to this experience

Mouse models for V103I and I251L gain of function variants of the human MC4R display decreased adiposity but are not protected against a hypercaloric diet

Objective: The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor that plays major roles in the central control of energy balance. Loss-of-function mutations of MC4R constitute the most common monogenic cause of early-onset extreme obesity in humans, whereas gain-offunction mutations appear to be protective. In particular, two relatively frequent alleles carrying the non-synonymous coding mutations V103I or I251L are associated with lower risks of obesity and type-2 diabetes. Although V103I and I251L MC4Rs showed more efficient signalling in transfected cells, their specific effects in live animals remain unexplored. Here, we investigated whether the introduction of V103I and I251L mutations into the mouse MC4R leads to a lean phenotype and provides protection against an obesogenic diet. Methods: Using CRISPR/Cas9, we generated two novel strains of mice carrying single-nucleotide mutations into the mouse Mc4r which are identical to those present in V103I and I251L MCR4 human alleles, and studied their phenotypic outcomes in mice fed with normal chow or a high-fat diet. In particular, we measured body weight progression, food intake and adiposity. In addition, we analysed glucose homeostasis through glucose and insulin tolerance tests. Results: We found that homozygous V103I females displayed shorter longitudinal length and decreased abdominal white fat, whereas homozygous I251L females were also shorter and leaner due to decreased weight in all white fat pads examined. Homozygous Mc4rV103I/V103I and Mc4rI251L/I251L mice of both sexes showed improved glucose homeostasis when challenged in a glucose tolerance test, whereas Mc4rI251L/I251L females showed improved responses to insulin. Despite being leaner and metabolically more efficient, V103I and I251L mutants fed with a hypercaloric diet increased their fasting glucose levels and adiposity similar to their wild-type littermates. Conclusions: Our results demonstrate that mice carrying V103I and I251L MC4R mutations displayed gain-of-function phenotypes that were more evident in females. However, hypermorphic MC4R mutants were as susceptible as their control littermates to the obesogenic and diabetogenic effects elicited by a long-term hypercaloric diet, highlighting the importance of healthy feeding habits even under favourable genetic conditions.Fil: Rojo, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Mccarthy, Clara Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Raingo, Jesica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. University of Michigan; Estados Unido

Leptin counteracts the hypoxia-induced inhibition of spontaneously firing hippocampal neurons: a microelectrode array study.

Besides regulating energy balance and reducing body-weight, the adipokine leptin has been recently shown to be neuroprotective and antiapoptotic by promoting neuronal survival after excitotoxic and oxidative insults. Here, we investigated the firing properties of mouse hippocampal neurons and the effects of leptin pretreatment on hypoxic damage (2 hours, 3% O(2)). Experiments were carried out by means of the microelectrode array (MEA) technology, monitoring hippocampal neurons activity from 11 to 18 days in vitro (DIV). Under normoxic conditions, hippocampal neurons were spontaneously firing, either with prevailing isolated and randomly distributed spikes (11 DIV), or with patterns characterized by synchronized bursts (18 DIV). Exposure to hypoxia severely impaired the spontaneous activity of hippocampal neurons, reducing their firing frequency by 54% and 69%, at 11 and 18 DIV respectively, and synchronized their firing activity. Pretreatment with 50 nM leptin reduced the firing frequency of normoxic neurons and contrasted the hypoxia-induced depressive action, either by limiting the firing frequency reduction (at both ages) or by increasing it to 126% (in younger neurons). In order to find out whether leptin exerts its effect by activating large conductance Ca(2+)-activated K(+) channels (BK), as shown on rat hippocampal neurons, we applied the BK channel blocker paxilline (1 µM). Our data show that paxilline reversed the effects of leptin, both on normoxic and hypoxic neurons, suggesting that the adipokine counteracts hypoxia through BK channels activation in mouse hippocampal neurons

In Vitro Bioaccessibility and Functional Properties of Phenolic Compounds from Enriched Beverages Based on Cocoa Bean Shell

The cocoa bean shell (CBS), a cocoa by-product, contains a significant amount of bioactive compounds with functional properties, such as polyphenols and methylxanthines, and is used as an ingredient in beverages and foods. In this work, the bioaccessibility of polyphenols and methylxanthines after in vitro digestion was evaluated in new flavoured beverages for at-home consumption (capsules and tea bags). In addition, the polyphenolic composition, functional properties (antiradical and -glucosidase inhibition capacities) and consumer acceptability of these beverages were evaluated. In both capsule and tea bag beverages, the bioaccessibility of methylxanthines was 100% while that of total polyphenols exceeded 50%. The main polyphenols determined using reverse-phase liquid chromatography were type B procyanidins and epicatechin. The antiradical activity in capsule and tea bag beverages was 1.75 and 1.88 mM of Trolox equivalents, respectively, of which 59.50% and 57.09% were recovered after simulated digestion. The percentage of -glucosidase inhibition before in vitro digestion (51.64% and 53.82% for capsules and tea bags, respectively) was comparable to that of acarbose at 0.5 mM. All the beverages obtained a high consumer acceptability. Therefore, these results highlight that CBSs can be used as a valid source of bioactive compounds in the preparation of beverages with homemade techniques.info:eu-repo/semantics/publishe

Practical guide pressure ulcers in Primary Care

Las UPP, son unas de las principales demandas realizadas al personal de enfermería de atención primaria, sobre todo en pacientes encamados de edad avanzada. Objetivos: Unificar los conocimientos de los enfermeros sobre la curación de úlceras por presión y Establecer criterios únicos para la evaluación del estadio de las úlceras por presión. Metodología: Se ha realizado una revisión bibliográfica Cochrane, PubMed y Scielo además de otros documentos, publicaciones y soportes web de ámbito científico. Resultados y conclusiones: Es básico identificar los factores de riesgo de las UPP para realizar una correcta valoración y tratamiento de las mismas.The UPP, are one of the main demands made to nurses primary care, especially in elderly bedridden patients. Objectives: Unifying the knowledge of nurses about the healing of pressure ulcers and establish unique criteria for evaluating the stage of pressure ulcers. Methodology: We performed a literature review Cochrane, PubMed and Scielo and other documents, publications and web media science. Results and conclusions: It is essential to identify risk factors for the UPP for proper evaluation and treatment thereof

Classification and measurement of burn patients by nurses

Introducción: Se define quemadura como un traumatismo que provoca afectación de la piel y tejidos adyacentes. Objetivos: Clasificar las quemaduras según el agente causal y gravedad de la lesión. Metodología: Revisión de literatura disponible en principales metabuscadores científicos, sin usar ninguna restricción de año ni idioma. Resultados y conclusiones: Se debe de conocer el agente causal y la profundidad de la quemadura, para poder realizar un correcto tratamiento de la misma, ya que cada tipo de quemadura necesita un tipo específico de cuidados.Introduction : Burnout is defined as a trauma that causes skin involvement and adjacent tissues. Objectives: Sort burns as the causative agent and severity of the injury. Methodology : Review of literature available in major scientific metasearch, without using any constraint year or language. Results and conclusions : We must know the causal agent and the depth of the burn, to perform correct treatment of the same, as each type of burn need a specific type of care

Guide to insercción a PICC line by registered nurses

El cateterismo venoso central de acceso periférico se utiliza para la administración de medicamentos, nutrición parenteral, hemoderivados, infusión de grandes volúmenes de fluidos en poco tiempo y sustancias agresivas garantizando así la permeabilidad. Objetivos: Identificar los pasos a seguir a la hora de la inserción de una PICC y enumerar las complicaciones potenciales. Metodología: Revisión bibliográfica en principales metabuscadores con restricción de año 2010 y sin restricciones de idioma. Resultados y conclusiones: Se ha de realizar una correcta inserción de la PICC y una valoración continua de permeabilidad y punto de inserción de la misma para evitar complicaciones potenciales.The central venous catheterization peripheral access is used for administration of drugs, parenteral nutrition, blood products, infusion of large volumes of fluids quickly and aggressive substances ensuring permeability. Objectives: To identify the steps to follow when inserting a PICC and list potential complications. Methodology: Literature review in major metasearch restricted 2010 without language restrictions. Results and conclusions: It is to make a correct insertion of the PICC and continuous assessment of permeability and insertion point of it to avoid potential complications

Descriptive guide about taxonomy nanda, nic and noc

Para un correcto desarrollo de un plan de cuidados, es necesario conocer y manejar la taxonomía NANDA, NIC y NOC. Objetivos: Conocer las diferentes taxonomías a la hora de realizar los planes de cuidados, Describiendo el proceso enfermero y formas de lograr los objetivos. Metodología: Se trata de una revisión bibliográfica de las diferentes taxonomías utilizadas. Resultados: Es necesario trabajar conjuntamente con las diferentes taxonomías para lograr unos resultados satisfactorios con los objetivos marcados. Conclusiones: Para lograr unos c uidados enfermeros de calidad es básico el realizar un plan de cuidados personalizado a cada paciente, realizando una evaluación continua.For proper development of a care plan, it is necessary to know and manage the NANDA, NIC and NOC taxonomy. Objectives: To know the different taxonomies when making care plans, Describing the nursing process and ways to achieve the objectives. Methodology : This is a literature review of the different taxonomies used.Results: We must work together with the different taxonomies to achieve satisfactory results with the objectives