Proper motions in the VVV Survey: Results for more than 15 million stars across NGC 6544

Context: In the last six years, the VVV survey mapped 562 sq. deg. across the bulge and southern disk of the Galaxy. However, a detailed study of these regions, which includes $\sim 36$ globular clusters (GCs) and thousands of open clusters is by no means an easy challenge. High differential reddening and severe crowding along the line of sight makes highly hamper to reliably distinguish stars belonging to different populations and/or systems. Aims: The aim of this study is to separate stars that likely belong to the Galactic GC NGC 6544 from its surrounding field by means of proper motion (PM) techniques. Methods: This work was based upon a new astrometric reduction method optimized for images of the VVV survey. Results: Photometry over the six years baseline of the survey allowed us to obtain a mean precision of $\sim0.51$ mas/yr, in each PM coordinate, for stars with Ks < 15 mag. In the area studied here, cluster stars separate very well from field stars, down to the main sequence turnoff and below, allowing us to derive for the first time the absolute PM of NGC 6544. Isochrone fitting on the clean and differential reddening corrected cluster color magnitude diagram yields an age of $\sim$ 11-13 Gyr, and metallicity [Fe/H] = -1.5 dex, in agreement with previous studies restricted to the cluster core. We were able to derive the cluster orbit assuming an axisymmetric model of the Galaxy and conclude that NGC 6544 is likely a halo GC. We have not detected tidal tail signatures associated to the cluster, but a remarkable elongation in the galactic center direction has been found. The precision achieved in the PM determination also allows us to separate bulge stars from foreground disk stars, enabling the kinematical selection of bona fide bulge stars across the whole survey area. Our results show that VVV data is perfectly suitable for this kind of analysis.Comment: 13 pages, 12 figures, accepted in A&

The VVV Survey RR Lyrae Population in the Galactic Center Region

Indexación: Scopus.We gratefully acknowledge the use of data from the ESO Public Survey program ID 179.B-2002 taken with the VISTA telescope, and data products from the Cambridge Astronomical Survey Unit (CASU). Support for the authors is provided by the BASAL Center for Astrophysics and Associated Technologies (CATA) through grant PFB-06, and the Ministry for the Economy, Development, and Tourism, Programa Iniciativa Cientifica Milenio through grant IC120009, awarded to the Millennium Institute of Astrophysics (MAS). D.M. and M.Z. acknowledge support from FONDECYT Regular grants No. 1170121, and 1150345, respectively. P.H. acknowledges financial support from FONDECYT regular grant 1170305. F.G. acknowledge support from CONICYT-PCHA Doctorado Nacional 2017-21171485 and Proyecto Fondecyt Regular 1150345. J.A.-G. acknowledges support by FONDECYT Iniciacion 11150916. D.M. is also grateful for the hospitality of the Vatican Observatory. This research made use of Astropy, a community-developed core Python package for astronomy; Scikit-learn, NumPy, and matplotlib, a Python library for publication-quality graphics; and Aladin Sky Atlas, developed at CDS, Strasbourg Observatory, France, and TOPCAT.Deep near-IR images from the VISTA Variables in the V a L ctea (VVV) Survey were used to search for RR Lyrae stars within 100 arcmin from the Galactic Center. A large sample of 960 RR Lyrae of type ab (RRab) stars were discovered. A catalog is presented featuring the positions, magnitudes, colors, periods, and amplitudes for the sample, in addition to estimated reddenings, distances, and metallicities, and measured individual relative proper motions. We use the reddening-corrected Wesenheit magnitudes, defined as WKs Ks 0.428 J Ks = - ( - ), in order to isolate bona fide RRL belonging to the Galaxy Center, finding that 30 RRab are foreground/background objects. We measure a range of extinctions from AKs 0.19 = to 1.75 mag for the RRab in this region, finding that large extinction is the main cause of the sample incompleteness. The mean period is P =0.5446±0.0025 days, yielding a mean metallicity of [Fe/H] =-1.30±0.01 (ς = 0.33) dex for the RRab sample in the Galactic Center region. The median distance for the sample is D =8.05±0.02 kpc. We measure the RRab surface density using the less reddened region sampled here, finding a density of 1000 RRab/sq deg at a projected Galactocentric distance RG =1.6 deg. Under simple assumptions, this implies a large total mass (M>109Me) for the old and metal-poor population contained inside RG. We also measure accurate relative proper motions, from which we derive tangential velocity dispersions of ςVl =125.0 and ςVb =124.1 km s-1 along the Galactic longitude and latitude coordinates, respectively. The fact that these quantities are similar indicate that the bulk rotation of the RRab population is negligible, and implies that this population is supported by velocity dispersion. In summary, there are two main conclusions of this study. First, the population as a whole is no different from the outer bulge RRab, predominantly a metal-poor component that is shifted with respect to the Oosterhoff type I population defined by the globular clusters in the halo. Second, the RRab sample, as representative of the old and metal-poor stellar population in the region, has high velocity dispersions and zero rotation, suggesting a formation via dissipational collapse. ©2018. The American Astronomical Society. All rights reserved.https://iopscience.iop.org/article/10.3847/1538-4357/aacf9

Institutional Repository saber.ula.ve: A testimonial perspective

In this paper, we describe our decade-long experience of building and operating one of the most active Institutional Repository in the world: www.saber.ula.ve (University of the Andes, Merida-Venezuela). In order to share our experience with other institutions, we firstly explain the steps we followed to preserve and disseminate the scientific production of the University of Los Andes' researchers. We then present some recent quantitative results about our repository activities and we outline some methodological guidelines that could be applied in order to replicate similar experiences. These guidelines list the ingredients or building blocks as well as the processes followed for developing and maintaining the services of an Institutional Repository. These include technological infrastructure; institutional policies on preservation, publication and dissemination of knowledge; recommendations on incentives for open access publication; the process of selection, testing and adaptation of technological tools; the planning and organization of services, and the dissemination and support within the scientific community that will eventually lead to the adoption of the ideas that lie behind the open access movement. We summarize the results obtained regarding the acceptance, adoption and use of the technological tools used for the publication of our institution's intellectual production, and we present the main obstacles encountered on the way.Comment: 7th International Conference on Open Access in Accra Ghana from 2nd to 3rd November 200

Comparative genomics, evolution, and drought-induced expression of dehydrin genes in model Brachypodium grasses

Dehydration proteins (dehydrins, DHNs) confer tolerance to water-stress deficit in plants. We performed a comparative genomics and evolutionary study of DHN genes in four model Brachy-podium grass species. Due to limited knowledge on dehydrin expression under water deprivation stress in Brachypodium, we also performed a drought-induced gene expression analysis in 32 ecotypes of the genus’ flagship species B. distachyon showing different hydric requirements. Genomic sequence analysis detected 10 types of dehydrin genes (Bdhn) across the Brachypodium species. Domain and conserved motif contents of peptides encoded by Bdhn genes revealed eight protein architectures. Bdhn genes were spread across several chromosomes. Selection analysis indicated that all the Bdhn genes were constrained by purifying selection. Three upstream cis-regulatory motifs (BES1, MYB124, ZAT) were detected in several Bdhn genes. Gene expression analysis demonstrated that only four Bdhn1-Bdhn2, Bdhn3, and Bdhn7 genes, orthologs of wheat, barley, rice, sorghum, and maize genes, were expressed in mature leaves of B. distachyon and that all of them were more highly expressed in plants under drought conditions. Brachypodium dehydrin expression was significantly correlated with drought-response phenotypic traits (plant biomass, leaf carbon and proline contents and water use efficiency increases, and leaf water and nitrogen content decreases) being more pronounced in drought-tolerant ecotypes. Our results indicate that dehydrin type and regulation could be a key factor determining the acquisition of water-stress tolerance in grasses. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

New molecular approaches in adipogenesis regulation: The connexin 43 role

Indexación: Scopus; Redalyc.La prevalencia de la obesidad a nivel mundial se ha incrementado rápidamente durante los últimos años debido principalmente a los cambios en el estilo de vida de la población con un aumento significativo en el consumo de energía y disminución de los niveles de actividad física. Es por esto que la comunidad científica está interesada en comprender de forma más profunda los mecanismos que regulan la fisiopatología de la obesidad. Dentro de los diferentes blancos de estudio se encuentra la adipogénesis, cuyo entendimiento es fundamental para comprender el desarrollo de la obesidad y las patologías asociadas a esta. Recientemente ha surgido importantes evidencias que involucran a la proteína de canales de “Gap Junction” conexina 43 (Cx43) en la regulación de los procesos relacionados con adipogénesis, cuyo papel es básicamente anti-adipogénico, sin embargo, nuevas funciones de Cx43 en la regulación de la formación del tejido adiposo siguen descubriéndose.The global prevalence of obesity has been increased rapidly over the past few years mainly due to changes in the lifestyle of the population with a significant increase in energy consumption and decreased levels of physical activity. As a result, the scientific community is interested in a deeper understanding of the mechanisms that regulate the pathophysiology of obesity. In this context, adipogenesis process is an important target of study to understand the obesity and associated pathologies. Recently has been emerged important evidence that involve gap junction channel protein connexin 43 (Cx43) in the regulation of processes related to adipogenesis, whose role is fundamentally anti-adipogenic. However, new functions of Cx43 in the regulation of adipose tissue function also continued to emerge.http://www.redalyc.org/articulo.oa?id=5594990800

High Levels of Academic Procrastination do not Influence the Academic Performance of Nursing Students during Internship

Introducción: La procrastinación académica (AP) es un fenómeno global que afecta significativamente a los estudiantes universitarios, influyendo potencialmente en su rendimiento académico y bienestar mental. Objetivo: Investigar la relación entre los niveles de procrastinación académica y el rendimiento académico de estudiantes de enfermería durante su pasantía en el Perú. Métodos: Se realizó un estudio transversal, involucrando a 112 pasantes de enfermería, de 18 años y más, matriculados en el semestre 2019-I. Los participantes completaron la Escala de Procrastinación Académica (EPA), una escala tipo Likert que consta de 12 ítems, que midió dos dimensiones: autorregulación académica (9 ítems) y procrastinación de actividades (3 ítems). Se utilizó una puntuación umbral de 36 puntos para identificar altos niveles de procrastinación académica. El rendimiento académico se evaluó en una escala de 0 a 10 (reprobado), 11 a 14 (aprobado), 15 a 17 (notable) y 18 a 20 (sobresaliente). Resultados: La edad media de los participantes fue de 29 años, siendo el 88,4% mujeres. El estudio encontró que el 72,3% de los estudiantes de enfermería exhibieron niveles más altos de AP, particularmente entre las mujeres (62,5%) y los estudiantes más jóvenes (59,8%). A escala global, el 70,3% de los estudiantes obtuvo una calificación notable, y el 51,8% de estos estudiantes también exhibió un alto nivel de AP. Sin embargo, no se encontraron diferencias significativas en el rendimiento académico según el nivel de AP (p=0,918). Conclusión: Aunque los estudiantes de enfermería mostraron un mayor nivel de AP, este estudio no encontró una asociación significativa entre la procrastinación académica y el rendimiento académico durante el período de prácticas. Sin embargo, es crucial monitorear la AP en estudiantes de enfermería a lo largo de sus estudios para identificar factores potenciales que puedan contribuir a su impacto y desarrollar estrategias para mitigar sus efectos

Imaging drug delivery to skin with stimulated Raman scattering microscopy

Efficient drug delivery to the skin is essential for the treatment of major dermatologic diseases, such as eczema, psoriasis and acne. However, many compounds penetrate the skin barrier poorly and require optimized formulations to ensure their bioavailability. Here, stimulated Raman scattering (SRS) microscopy, a recently-developed, label-free chemical imaging tool, is used to acquire high resolution images of multiple chemical components of a topical formulation as it penetrates into mammalian skin. This technique uniquely provides label-free, non-destructive, three-dimensional images with high spatiotemporal resolution. It reveals novel features of (trans)dermal drug delivery in the tissue environment: different rates of drug penetration via hair follicles as compared to the intercellular pathway across the stratum corneum are directly observed, and the precipitation of drug crystals on the skin surface is visualized after the percutaneous penetration of the co-solvent excipient in the formulation. The high speed three-dimensional imaging capability of SRS thus reveals features that cannot be seen with other techniques, providing both kinetic information and mechanistic insight into the (trans)dermal drug delivery process

The VVV survey: Long-period variable stars I. Photometric catalog of ten VVV/OGLE tiles

Long-period variable stars (LPVs) are pulsating red giants, primarily in the asymptotic giant branch phase, and they include both Miras and semi-regular variables (SRVs). Their period-age and period-luminosity relations enable us to trace different stellar populations, as they are intrinsically very bright and cover a wide range in distances and ages. The purpose of this study is to establish a census of LPV stars in a region close to the Galactic center, using the six-year database of the Vista Variables in the V\'ia L\'actea (VVV) ESO Public Survey, as well as to describe the methodology that was employed to search for and characterize LPVs using VVV data. Near-IR surveys such as VVV provide a unique opportunity to probe the high-extinction innermost regions of the Milky Way. The detection and analysis of the intrinsically bright Miras in this region could provide us with an excellent probe of the properties of the Milky Way far behind its bulge. We used point-spread function photometry for all available $K_{s}$-band images in ten VVV tiles, covering $16.4~\deg^2$ in total, overlapping fields observed in the course of the Optical Gravitational Lensing Experiment (OGLE)-III survey. We designed a method to select LPV candidates, and we used the known variables from OGLE-III and other known variables from the literature to test our approach. The reduced $\chi^2$ statistic, along with the flux-independent index $K_{(fi)}$, were used in our analysis. The Lomb-Scargle period search method, Fourier analysis, template fitting, and visual inspection were then performed to refine our sample and characterize the properties of the stars included in our catalog. A final sample of 130 Mira candidates, of which 129 are new discoveries, was thus obtained, with periods in the range between about 80 and 1400~days