Automation of the solution of the reverse problems of economic analysis

In this article, we consider the solution of inverse problems of economic analysis by the method of coefficients of relative importance and automation of the solution. The result of the research is the development and implementation of automation of solving the inverse problems of economic analysis, for making decisions in economic problems

Магнитоэлектрический двигатель для привода рулевой колонки автотранспортного средства

Научная квалификационная работа посещена исследованию пульсаций электромагнитного момента в магнитоэлектрическом двигателе рулевой колонки автотранспортного средства. В первой главе выполнен обзор исследований на тему магнитоэлектрических машин с различной компоновкой магнитов на роторе и осуществлена постановка задачи научной квалификационной работы. Во второй главе рассмотрены вопросы имитационного моделирования магнитоэлектрической машины в конечно-элементной компьютерной среде. Выполнено планирование эксперимента, получена взаимосвязь между количеством пазов ротора, зубцами статора, коэрцитивной силы магнитов с позиции значений электромагнитного момента. В третьей главе выполнен расчет связанной модели магнитоэлектрический двигатель-инвертор напряжения-система управления.Scientific qualification work is visited to a research of pulsations of the electromagnetic torque in the magnetoelectric motor of a steering column of the vehicle. In chapter 1 the review of researches on magnetoelectric machine with various configuration of magnets on a rotor is executed and problem definition of scientific qualification work is carried out. In chapter 2 questions of a simulation modeling of the magnetoelectric machine in the terminating and element computer environment are considered. Scheduling of an experiment is executed, the interrelation between quantity of poles of a rotor, tooths of a stator, a coercive force of magnets from a position of values of the electromagnetic torque is received. In a chapter 3 calculation of the bound model the magnetoelectric motor

The Importance of the Hedgehog Signaling Pathway in Tumorigenesis of Spinal and Cranial Chordoma

Chordomas is rare malignant bone tumors thought to arise from remnants of embryonic notochord along the spine, frequently at the skull base and sacrum. Although chordoma is slow growing tumors, while are extremely recurrent, and aggressive, as well as the rate of prognosis remains poorly. Radical surgery and high-dose radiation are the most used treatments. Currently, there is no effective chemotherapeutic standard for chordomas. The Hedgehog (HH) pathway adjusts various processes included in expansion and differentiation of tissues and organs throughout the fetus’s life, furthermore cell growth and differentiation in the adult organism, of the cell in an adult organism, in which acute anesthesia is involved in multiple cancers. To study the role of signaling the hedgehog in the base of the skull and sacrum chordomas, the expression of SHH and GLI-1 levels were detected immuno histochemically, Additionally, PTCH-1 and GLI-1 expressions were distinguished by in- Situ- hybridization. Based on the findings presented herein, it is likely that the HH signal cascade was revealed even in cranial, where consecoently spinal chordoma and their recurrences play an important role. Our staining exhibited a canonical, ligand- dependent and autocrine Hedgehog signaling in skull base and sacrum chordomas including relapse. Due to the high levels of SHH and GLI-1 expression in all investigated chordoma samples, the study suggests a possible autocrine ligand-dependent activation of the canonical HH signaling cascade. A paracrine or non-canonical pathway cannot be excluded. Our results suggest that Hedgehog-inhibitors, like SHH-, GLI- and SMO- inhibitors, might serve as a potential and effective target for the treatment of chordomas

Оценка эффективности использования трудовых ресурсов на предприятии

Объектом исследования является: улучшение эффективности трудовых ресурсов. Цель работы – провести анализ обеспеченности предприятия трудовыми ресурсами предприятия и выявить пути их оптимизации. В процессе исследования проводились: изучение принципов учета производственных затрат на предприятиях РФ и Узбекистана, определены значение и задачи учёта затрат на производство и анализа себестоимости продукции; рассмотрены объекты калькулирования при расчете себестоимости продукции, исследованы основные виды классификации затрат на производство; проанализирован состав и структура затрат на производство; для полного вывода о возможности взыскания резервов снижения себестоимости проведён анализ себестоимости по статьям затрат, при этом отдельно проанализированы прямые и косвенные затраты; при выпоThe object of this study is to: improve the efficiency of labor. The purpose of work - to analyze the security of the enterprise enterprise human resources and to identify ways to optimize them. The study carried out: study of the principles of accounting of production costs at the enterprises of the Russian Federation and Uzbekistan, to determine the values ​​and objectives taking into account the cost of production and the analysis of the cost of production; Consider the object of calculation when calculating the cost of production, study the main types of classification of production costs; It analyzed the composition and structure of the production costs; for the complete withdrawal of the recoverability of reserves to reduce production costs conducted cost analysis by cost, with dire

Perioperative course and accuracy of screw positioning in conventional, open robotic-guided and percutaneous robotic-guided, pedicle screw placement

Robotic-guided and percutaneous pedicle screw placement are emerging technologies. We here report a retrospective cohort analysis comparing conventional open to open robotic-guided and percutaneous robotic-guided pedicle screw placement. 112 patient records and CT scans were analyzed concerning the intraoperative and perioperative course. 35 patients underwent percutaneous, 20 open robotic-guided and 57 open conventional pedicle screw placement. 94.5% of robot-assisted and 91.4% of conventionally placed screws were found to be accurate. Percutaneous robotic and open robotic-guided subgroups did not differ obviously. Average X-ray exposure per screw was 34 s in robotic-guided compared to 77 s in conventional cases. Subgroup analysis indicates that percutaneously operated patients required less opioids, had a shorter hospitalization and lower rate of adverse events in the perioperative period. The use of robotic guidance significantly increased accuracy of screw positioning while reducing the X-ray exposure. Patients seem to have a better perioperative course following percutaneous procedures

Способы модифицирования сварного соединения нанопорошками

В статье рассмотрены способы модифицирования сварного соединения наноструктурированными порошками

Роль текстурированного инструмента в повышении эффективности процесса обработки резанием

Текстурирование поверхности является одним из перспективных методов, который влияет на улучшение трибологических свойств инструментов. Текстуры поверхности имеют разный геометрический размер, форму и, как правило, создаются либо на боковой поверхности, либо на передней поверхности режущего инструмента. Качество текстуры в значительной степени зависит от производственных процессов, которые были использованы