Accelerated DPDK in containers for networking nodes

NFV is fast moving towards containers for software virtualization and thereby imposing stringent requirements on container networking. The current status of networking in containers is quite limited especially for fast packet processing and needs further exploration. The thesis is a comprehensive study on container networking for fast packet processing in standalone and orchestrated environments. Existing technologies such as DPDK and SR-IOV are utilized along with OvS and OVN to build different topologies and measure network latency. Utilizing these results and taking into account the hardware features supported by different nodes in an orchestrated environment, the thesis further proposes a latency based scheduler that can meet the network latency requirements of container applications being deployed

Framework For a Collective Definition of Regenerative Agriculture in India

The concept of regenerative agriculture has received increasing attention worldwide as a method to restore and conserve natural resources while maintaining crop productivity. However, there remains a lack of consensus as to what conditions define regenerative agriculture, making it difficult for decision-makers, researchers, the agricultural sector, and the public to adopt regenerative agriculture practices. Here, we present the initial process to create a unified, cross-sectoral definition for regenerative agriculture in India that considers the viewpoints of multiple stakeholders and addresses the current challenges faced by the Indian agricultural sector. To this end, we compiled interactions with individuals from across India to identify the most pressing concerns for India's human and environmental ecosystems. We conducted over 30 hours of workshops to discuss these concerns with 50 experts from five sectors and four countries

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)

Pregnancy through assisted reproductive technology in a patient with thoracic endometriosis syndrome

Extrapelvic endometriosis is known to be difficult to diagnose. Appropriate management in an infertile patient with extrapelvic endometriosis is not only difficult but also not well established. This case report describes a patient with thoracic endometriosis syndrome who was managed successfully for controlling her pleural endometriosis and achieving a pregnancy through assisted reproductive technology (ART)

Framework For a Collective Definition of Regenerative Agriculture in India

The concept of regenerative agriculture has received increasing attention worldwide as a method to restore and conserve natural resources while maintaining crop productivity. However, there remains a lack of consensus as to what conditions define regenerative agriculture, making it difficult for decision-makers, researchers, the agricultural sector, and the public to adopt regenerative agriculture practices. Here, we present the initial process to create a unified, cross-sectoral definition for regenerative agriculture in India that considers the viewpoints of multiple stakeholders and addresses the current challenges faced by the Indian agricultural sector. To this end, we compiled interactions with individuals from across India to identify the most pressing concerns for India’s human and environmental ecosystems. We conducted over 30 hours of workshops to discuss these concerns with 50 experts from five sectors and four countries. We summarize these discussions and propose a common framework to collaboratively develop region-specific techniques that employ existing and supplementary resources to generate evidence for regenerative agriculture and foster conducive practices