5,466 research outputs found
Electronic Structure of Electron-doped Sm1.86Ce0.14CuO4: Strong `Pseudo-Gap' Effects, Nodeless Gap and Signatures of Short Range Order
Angle resolved photoemission (ARPES) data from the electron doped cuprate
superconductor SmCeCuO shows a much stronger pseudo-gap
or "hot-spot" effect than that observed in other optimally doped -type
cuprates. Importantly, these effects are strong enough to drive the
zone-diagonal states below the chemical potential, implying that d-wave
superconductivity in this compound would be of a novel "nodeless" gap variety.
The gross features of the Fermi surface topology and low energy electronic
structure are found to be well described by reconstruction of bands by a
order. Comparison of the ARPES and optical data from
the sample shows that the pseudo-gap energy observed in optical data is
consistent with the inter-band transition energy of the model, allowing us to
have a unified picture of pseudo-gap effects. However, the high energy
electronic structure is found to be inconsistent with such a scenario. We show
that a number of these model inconsistencies can be resolved by considering a
short range ordering or inhomogeneous state.Comment: 5 pages, 4 figure
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Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration
Retinitis pigmentosa comprises a group of inherited retinal photoreceptor degenerations that lead to progressive loss of vision. Although in most cases rods, but not cones, harbor the deleterious gene mutations, cones do die in this disease, usually after the main phase of rod cell loss. Rod photoreceptor death is characterized by apoptotic features. In contrast, the mechanisms and features of subsequent nonautonomous cone cell death remain largely unknown. In this study, we show that receptor-interacting protein (RIP) kinase mediates necrotic cone cell death in rd10 mice, a mouse model of retinitis pigmentosa caused by a mutation in a rod-specific gene. The expression of RIP3, a key regulator of programmed necrosis, was elevated in rd10 mouse retinas in the phase of cone but not rod degeneration. Although rd10 mice lacking Rip3 developed comparable rod degeneration to control rd10 mice, they displayed a significant preservation of cone cells. Ultrastructural analysis of rd10 mouse retinas revealed that a substantial fraction of dying cones exhibited necrotic morphology, which was rescued by Rip3 deficiency. Additionally, pharmacologic treatment with a RIP kinase inhibitor attenuated histological and functional deficits of cones in rd10 mice. Thus, necrotic mechanisms involving RIP kinase are crucial in cone cell death in inherited retinal degeneration, suggesting the RIP kinase pathway as a potential target to protect cone-mediated central and peripheral vision loss in patients with retinitis pigementosa
Global evaluation of Doppler velocity errors of EarthCARE cloud-profiling radar using a global storm-resolving simulation
The cloud-profiling radar (CPR) on the Earth Clouds,
Aerosol, and Radiation Explorer (EarthCARE) satellite (EC-CPR) is the first
satellite-borne Doppler radar. In a previous study, we examined
the effects of horizontal (along-track) integration and simple unfolding
methods on the reduction of Doppler errors in the EC-CPR observations, and
those effects were evaluated using two limited scenes in limited-latitude
and low-pulse-repetition-frequency (PRF) settings. In this study, the amount
of data used was significantly increased, and the area of the data used was
extended globally. Not only low-PRF but also high-PRF settings were
examined. We calculated the EC-CPR-observed Doppler velocity from pulse-pair
covariances using the radar reflectivity factor and Doppler velocity
obtained from a satellite data simulator and a global storm-resolving
simulation. The global data were divided into five latitudinal zones, and
each standard deviation of Doppler errors for 5 dBZe after 10 km
integration was calculated. In the case of the low-PRF setting, the error
without unfolding correction for the tropics reached a maximum of 2.2 m s−1 and then decreased toward the poles (0.43 m s−1). The error
with unfolding correction for the tropics became much smaller at 0.63 m s−1. In the case of the high-PRF setting, the error without unfolding
correction for the tropics reached a maximum of 0.78 m s−1 and then
decreased toward the poles (0.19 m s−1). The error with unfolding
correction for the tropics was 0.29 m s−1, less than half the value
without the correction. The results of the analyses of the simulated data
indicated that the zonal mean frequency of precipitation echoes was highest
in the tropics and decreased toward the poles. Considering a limitation of
the unfolding correction for discrimination between large upward velocity
and large precipitation falling velocity, the latitudinal variation in the
standard deviation of Doppler error can be explained by the precipitation
echo distribution.</p
The Hamiltonian boundary term and quasi-local energy flux
The Hamiltonian for a gravitating region includes a boundary term which
determines not only the quasi-local values but also, via the boundary variation
principle, the boundary conditions. Using our covariant Hamiltonian formalism,
we found four particular quasi-local energy-momentum boundary term expressions;
each corresponds to a physically distinct and geometrically clear boundary
condition. Here, from a consideration of the asymptotics, we show how a
fundamental Hamiltonian identity naturally leads to the associated quasi-local
energy flux expressions. For electromagnetism one of the four is distinguished:
the only one which is gauge invariant; it gives the familiar energy density and
Poynting flux. For Einstein's general relativity two different boundary
condition choices correspond to quasi-local expressions which asymptotically
give the ADM energy, the Trautman-Bondi energy and, moreover, an associated
energy flux (both outgoing and incoming). Again there is a distinguished
expression: the one which is covariant.Comment: 12 pages, no figures, revtex
Shocked Molecular Gas in the Supernova Remnant HB 21
We report the discovery of the shocked molecular gas in the supernova remnant
HB 21. We derive the physical parameters of the shocked gas from CO J=1-0 and
J=2-1 line observations. We discuss the correlation of the shocked molecular
gas with the previously detected, shocked atomic gas and the associated
infrared emission.Comment: 24 pages, 10 figures, To appear in the ApJ, scheduled for the April
10, 2001 issue (v551
An initial event in insect innate immune response: structural and biological studies of interactions between β-1,3-glucan and the N-terminal domain of β-1,3-glucan recognition protein
In response to invading microorganisms, insect β-1,3-glucan recognition protein (βGRP), a soluble receptor in the hemolymph, binds to the surfaces of bacteria and fungi and activates serine protease cascades that promote destruction of pathogens by means of melanization or expression of antimicrobial peptides. Here we report on the NMR solution structure of the N-terminal domain of βGRP (N-βGRP) from Indian meal moth (Plodia interpunctella), which is sufficient to activate the prophenoloxidase (proPO) pathway resulting in melanin formation. NMR and isothermal calorimetric titrations of N-βGRP with laminarihexaose, a glucose hexamer containing β-1,3 links, suggest a weak binding of the ligand. However, addition of laminarin, a glucose polysaccharide (~ 6 kDa) containing β-1,3 and β-1,6 links that activates the proPO pathway, to N-βGRP results in the loss of NMR cross-peaks from the backbone 15N-1H groups of the protein, suggesting the formation of a large complex. Analytical ultra centrifugation (AUC) studies of formation of N-βGRP:laminarin complex show that ligand-binding induces sel-fassociation of the protein:carbohydrate complex into a macro structure, likely containing six protein and three laminarin molecules (~ 102 kDa). The macro complex is quite stable, as it does not undergo dissociation upon dilution to sub-micromolar concentrations. The structural model thus derived from the present studies for N-βGRP:laminarin complex in solution differs from the one in which a single N-βGRP molecule has been proposed to bind to a triple helical form of laminarin on the basis of an X-ray crystallographic structure of N-βGRP:laminarihexaose complex [Kanagawa, M., Satoh, T., Ikeda, A., Adachi, Y., Ohno, N., and Yamaguchi, Y. (2011) J. Biol. Chem. 286, 29158-29165]. AUC studies and phenoloxidase activation measurements carried out with the designed mutants of N-βGRP indicate that electrostatic interactions involving Asp45, Arg54, and Asp68 between the ligand-bound protein molecules contribute in part to the stability of N-βGRP:laminarin macro complex and that a decreased stability is accompanied by a reduced activation of the proPO pathway. Increased β-1,6 branching in laminarin also results in destabilization of the macro complex. These novel findings suggest that ligand-induced self-association of βGRP:β-1,3-glucan complex may form a platform on a microbial surface for recruitment of downstream proteases, as a means of amplification of the initial signal of pathogen recognition for the activation of the proPO pathway
Search for Anisotropy of Ultra-High Energy Cosmic Rays with the Telescope Array Experiment
We study the anisotropy of Ultra-High Energy Cosmic Ray (UHECR) events
collected by the Telescope Array (TA) detector in the first 40 months of
operation. Following earlier studies, we examine event sets with energy
thresholds of 10 EeV, 40 EeV, and 57 EeV. We find that the distributions of the
events in right ascension and declination are compatible with an isotropic
distribution in all three sets. We then compare with previously reported
clustering of the UHECR events at small angular scales. No significant
clustering is found in the TA data. We then check the events with E>57 EeV for
correlations with nearby active galactic nuclei. No significant correlation is
found. Finally, we examine all three sets for correlations with the large-scale
structure of the Universe. We find that the two higher-energy sets are
compatible with both an isotropic distribution and the hypothesis that UHECR
sources follow the matter distribution of the Universe (the LSS hypothesis),
while the event set with E>10 EeV is compatible with isotropy and is not
compatible with the LSS hypothesis at 95% CL unless large deflection angles are
also assumed. We show that accounting for UHECR deflections in a realistic
model of the Galactic magnetic field can make this set compatible with the LSS
hypothesis.Comment: 10 pages, 9 figure
The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts
The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response. NDRG1 is expressed in primary human trophoblasts, where it promotes cell viability and resistance to hypoxic injury. The mechanism of action of NDRG1 remains unknown. To gain further insight into the intracellular action of NDRG1, we analyzed the expression pattern and cellular localization of endogenous NDRG1 and transfected Myc-tagged NDRG1 in human trophoblasts exposed to diverse injuries. In standard conditions, NDRG1 was diffusely expressed in the cytoplasm at a low level. Hypoxia or the hypoxia mimetic cobalt chloride, but not serum deprivation, ultraviolet (UV) light, or ionizing radiation, induced the expression of NDRG1 in human trophoblasts and the redistribution of NDRG1 into the nucleus and cytoplasmic membranes associated with the endoplasmic reticulum (ER) and microtubules. Mutation of the phosphopantetheine attachment site (PPAS) within NDRG1 abrogated this pattern of redistribution. Our results shed new light on the impact of cell injury on NDRG1 expression patterns, and suggest that the PPAS domain plays a key role in NDRG1's subcellular distribution. © 2013 Shi et al
Another positivity proof and gravitational energy localizations
Two locally positive expressions for the gravitational Hamiltonian, one using
4-spinors the other special orthonormal frames, are reviewed. A new quadratic
3-spinor-curvature identity is used to obtain another positive expression for
the Hamiltonian and thereby a localization of gravitational energy and positive
energy proof. These new results provide a link between the other two methods.
Localization and prospects for quasi-localization are discussed.Comment: 14 pages REVTe
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