7 research outputs found

    The Research Roadmap: A Primer To The Approach And Process

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    Performing research can be an overwhelming and challenging endeavor.  It’s easy to get confused just from collecting, reading and deciphering textbooks and journal articles. Getting organized and mapping out the entire process would be extremely helpful and more importantly provide a path for accomplishing the research project.  This paper will provide a research roadmap that can be used as a guide for accomplishing a research project or a doctoral dissertation.  It will discuss research methods, ethics in research, key components, and provide a comprehensive graphic that can be used as a guide to quick-start the research effort

    Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial

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    BackgroundAnterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients with a non-acute ACL injury and persistent symptoms of instability.MethodsWe did a pragmatic, multicentre, superiority, randomised controlled trial in 29 secondary care National Health Service orthopaedic units in the UK. Patients with symptomatic knee problems (instability) consistent with an ACL injury were eligible. We excluded patients with meniscal pathology with characteristics that indicate immediate surgery. Patients were randomly assigned (1:1) by computer to either surgery (reconstruction) or rehabilitation (physiotherapy but with subsequent reconstruction permitted if instability persisted after treatment), stratified by site and baseline Knee Injury and Osteoarthritis Outcome Score—4 domain version (KOOS4). This management design represented normal practice. The primary outcome was KOOS4 at 18 months after randomisation. The principal analyses were intention-to-treat based, with KOOS4 results analysed using linear regression. This trial is registered with ISRCTN, ISRCTN10110685, and ClinicalTrials.gov, NCT02980367.FindingsBetween Feb 1, 2017, and April 12, 2020, we recruited 316 patients. 156 (49%) participants were randomly assigned to the surgical reconstruction group and 160 (51%) to the rehabilitation group. Mean KOOS4 at 18 months was 73·0 (SD 18·3) in the surgical group and 64·6 (21·6) in the rehabilitation group. The adjusted mean difference was 7·9 (95% CI 2·5–13·2; p=0·0053) in favour of surgical management. 65 (41%) of 160 patients allocated to rehabilitation underwent subsequent surgery according to protocol within 18 months. 43 (28%) of 156 patients allocated to surgery did not receive their allocated treatment. We found no differences between groups in the proportion of intervention-related complications.InterpretationSurgical reconstruction as a management strategy for patients with non-acute ACL injury with persistent symptoms of instability was clinically superior and more cost-effective in comparison with rehabilitation management

    That's Cheating: The (Online) Academic Cheating 'Epidemic' and What We Should Do About It

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    This chapter argues that good practice in (online) teaching such as discussed in this book should recognise that cheating by students, for example, plagiarism, essay mills, impersonation, etc., has become more common and that it should be addressed with greater determination. This assertion is based on the experience, enquiries and views of an academic practitioner. The chapter considers what academic cheating is, the digital age’s impact on it and some of the moral justifications raised for and against cheating. It explains some of the ways in which online opportunities aid cheating, offers some ideas about how such cheating can be detected and concludes by arguing that much more could and should be done to prevent and respond to it

    Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

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