A first update on mapping the human genetic architecture of COVID-19

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British business and the politics of trade with the USSR during the New Economic Policy (NEP)

British commercial and political hopes to expand trade in the new Soviet state after 1920 were to an extent disappointed. Despite successful ventures by individual companies, in aggregate business fell short of expectations, especially compared with German and American competitors. The reasons were both (micro and macro) economic variables and political factors, in Britain and the USSR. From 1926 the Soviet regime was committed to rapid industrialization and a pattern of imports in which Germany enjoyed some comparative advantage. But, in contrast to major rivals, British governments occasionally tried to use trade as a political instrument to the disadvantage of commercial operations.Foreign Trade, Britain, USSR, Soviet Union, NEP, New Economic Policy, Concessions, Export,

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease