Prognostic impact of meningeal dissemination in primary CNS lymphoma (PCNSL): experience from the G-PCNSL-SG1 trial

Background We evaluated the frequency and prognostic impact of meningeal dissemination (MD) in immunocompetent adult patients with primary central nervous system lymphoma treated in a randomized phase III trial. Patients and methods MD was evaluated at study entry and defined by lymphoma proof in the meningeal compartment detected by at least one of the following methods: cerebrospinal fluid (CSF) cytomorphology, detection of clonal B cells by IgH PCR in CSF or contrast enhancement of the leptomeninges on magnetic resonance imaging (MRI). Results Data on MD were available in 415 patients, of those, MD was detected in 65 (15.7%): in 44/361 (12.2%) by CSF cytomorphology, in 16/152 (10.5%) by PCR and in 17/415 (4.1%) by MRI. Major patients' characteristics and therapy did not significantly differ between patients with MD (MD+) versus those without MD (MD−). There was a significant correlation of MD with CSF pleocytosis (>5/μl; P45 mg/dl). Median progression-free survival was 6.7 months [95% confidence interval (CI) 0-14.5] in MD+ and 8.3 months (5.7-10.8) in MD− patients (P=0.95); median overall survival was 21.5 months (95% CI 16.8-26.1) and 24.9 months (17.5-32.3), respectively (P=0.98). Conclusion MD was detected infrequently and had no impact on outcome in this tria

EC87-160 Musk Thistle....Its Appearance, Spread and Control

Extension circular 87-160 is about musk thistle, its appearance, spread and control

G92-1071 Ridge Plant Systems: Weed Control

Advantages and disadvantages of the ridge plant system, weed control before and at planting and economics of the system are discussed. Ridge planting combines tillage and herbicides to achieve improved weed control in row crops. Crop seed is planted into ridges formed during cultivation and/or ditching of the previous crop. In ridge planting, the planter follows the old row and ridge clearing sweeps or disks move the surface soil, residue and much of the weed seed out of the row. Weed seeds are deposited between the rows where, upon germination, they can be controlled with cultivation. Two cultivations are generally used for weed control. The first cultivation loosens the soil and the second rebuilds the ridge. The ridge plant system is well suited to furrow-irrigationd crops. It also works well with dryland crops or those under center pivot irrigation. On furrow irrigationd land, corn or sorghum stalks may need to be shredded to assist in decomposition and hence irrigation because crop residue slows water advance in the furrow. Slowing the water may be a benefit, however, on soils which have a low water intake rate. With center pivot and dryland acres the need for shredding depends on how much residue the cultivator can handle

G92-1071 Ridge Plant Systems: Weed Control

Advantages and disadvantages of the ridge plant system, weed control before and at planting and economics of the system are discussed. Ridge planting combines tillage and herbicides to achieve improved weed control in row crops. Crop seed is planted into ridges formed during cultivation and/or ditching of the previous crop. In ridge planting, the planter follows the old row and ridge clearing sweeps or disks move the surface soil, residue and much of the weed seed out of the row. Weed seeds are deposited between the rows where, upon germination, they can be controlled with cultivation. Two cultivations are generally used for weed control. The first cultivation loosens the soil and the second rebuilds the ridge. The ridge plant system is well suited to furrow-irrigationd crops. It also works well with dryland crops or those under center pivot irrigation. On furrow irrigationd land, corn or sorghum stalks may need to be shredded to assist in decomposition and hence irrigation because crop residue slows water advance in the furrow. Slowing the water may be a benefit, however, on soils which have a low water intake rate. With center pivot and dryland acres the need for shredding depends on how much residue the cultivator can handle

EC05-130 Guide for Weed Management in Nebraska

One of the major thrusts of all University of Nebraska weed science faculty is the Guide for Weed Management in Nebraska. This guide is not just the work of one or two people, rather it is a joint effort of all the authors to produce a comprehensive, information-packed resource. Each weed science faculty member is responsible for particular sections of the guide. The process of reviewing the current content, checking labels and research data and updating the content can be an extensive process. Each year new herbicide active ingredients and trade names are introduced and figuring out what a herbicide is and what it can control can be a sizeable task. The authors also meet twice a year to discuss feedback from readers, how the current guide is being used, and what changes should be made in the future. This circular deals principally with herbicides as an aid for crop production. The suggestions for use are based on results at Nebraska research centers and elsewhere. Consult product labels for additional information

Guide for Weed Management in Nebraska

Each year we strive to provide a publication that is updated, informative, and easy to use. Last year’s edition has been revised to include the latest research-based information and several new sections outlined below. We hope you find these revisions useful and that they make this guide an even better resource than the previous edition

Guide for Weed Management in Nebraska

Each year we strive to provide a publication that is updated, informative, and easy to use. Last year’s edition has been revised to include the latest research-based information and several new sections outlined below. We hope you find these revisions useful and that they make this guide an even better resource than the previous edition

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

To facilitate viral infection and spread, HIV-1 Nef disrupts the surface expression of the viral receptor (CD4) and molecules capable of presenting HIV antigens to the immune system (MHC-I). To accomplish this, Nef binds to the cytoplasmic tails of both molecules and then, by mechanisms that are not well understood, disrupts the trafficking of each molecule in different ways. Specifically, Nef promotes CD4 internalization after it has been transported to the cell surface, whereas Nef uses the clathrin adaptor, AP-1, to disrupt normal transport of MHC-I from the TGN to the cell surface. Despite these differences in initial intracellular trafficking, we demonstrate that MHC-I and CD4 are ultimately found in the same Rab7+ vesicles and are both targeted for degradation via the activity of the Nef-interacting protein, β-COP. Moreover, we demonstrate that Nef contains two separable β-COP binding sites. One site, an arginine (RXR) motif in the N-terminal α helical domain of Nef, is necessary for maximal MHC-I degradation. The second site, composed of a di-acidic motif located in the C-terminal loop domain of Nef, is needed for efficient CD4 degradation. The requirement for redundant motifs with distinct roles supports a model in which Nef exists in multiple conformational states that allow access to different motifs, depending upon which cellular target is bound by Nef

A Functional Genomic Screen Combined with Time-Lapse Microscopy Uncovers a Novel Set of Genes Involved in Dorsal Closure of Drosophila Embryos

Morphogenesis, the establishment of the animal body, requires the coordinated rearrangement of cells and tissues regulated by a very strictly-determined genetic program. Dorsal closure of the epithelium in the Drosophila melanogaster embryo is one of the best models for such a complex morphogenetic event. To explore the genetic regulation of dorsal closure, we carried out a large-scale RNA interference-based screen in combination with in vivo time-lapse microscopy and identified several genes essential for the closure or affecting its dynamics. One of the novel dorsal closure genes, the small GTPase activator pebble (pbl), was selected for detailed analysis. We show that pbl regulates actin accumulation and protrusion dynamics in the leading edge of the migrating epithelial cells. In addition, pbl affects dorsal closure dynamics by regulating head involution, a morphogenetic process mechanically coupled with dorsal closure. Finally, we provide evidence that pbl is involved in closure of the adult thorax, suggesting its general requirement in epithelial closure processes

First results on ProtoDUNE-SP liquid argon time projection chamber performance from a beam test at the CERN Neutrino Platform

The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber with an active volume of 7.2× 6.1× 7.0 m3. It is installed at the CERN Neutrino Platform in a specially-constructed beam that delivers charged pions, kaons, protons, muons and electrons with momenta in the range 0.3 GeV/c to 7 GeV/c. Beam line instrumentation provides accurate momentum measurements and particle identification. The ProtoDUNE-SP detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment, and it incorporates full-size components as designed for that module. This paper describes the beam line, the time projection chamber, the photon detectors, the cosmic-ray tagger, the signal processing and particle reconstruction. It presents the first results on ProtoDUNE-SP\u27s performance, including noise and gain measurements, dE/dx calibration for muons, protons, pions and electrons, drift electron lifetime measurements, and photon detector noise, signal sensitivity and time resolution measurements. The measured values meet or exceed the specifications for the DUNE far detector, in several cases by large margins. ProtoDUNE-SP\u27s successful operation starting in 2018 and its production of large samples of high-quality data demonstrate the effectiveness of the single-phase far detector design