Pain, Functional Disability, Psychological Status, and Health-Related Quality of Life in Patients with Subacromial Impingement Syndrome

Background Subacromial impingement syndrome (SAIS) is the comments painful shoulder condition leading to considerable functional loss. Considering numerous existing conservative and surgical interventions for SAIS, the use of optimal patient-centred outcome measures is essential. Study assessed various generic and shoulder-specific outcome measures in patients and healthy controls to provide baseline data and facilitate the development of evidence-based interventions. Methods A total of 75 participants including 39 patients and 36 healthy controls were evaluated and compared by a battery of validated outcome tools: McGill Pain Questionnaire, Oxford Shoulder Score, Constant Murley Score, The Disability of the Arm, Shoulder and Hand, Upper Limb Function Index, Functional Impairment Test–Hand and Neck/Shoulder/Arm, Hospital Anxiety and Depression Scale, Short-Form Health Survey, and shoulder muscle strength. Results All selected measures showed significant differences in the pain experience, upper limb functional capacity, psychological status (anxiety and depression), and health-related quality of life between SAIS patients and healthy controls in both female and male participant groups (p<0.05 - p<0.001). Conclusion The use of an array of patient-centred upper limb regional/joint-specific pain and functional measures combined with psychological status and quality of life tools is recommended for the evidence-based assessment of intervention outcome in patients with SAIS

A Comparative Study of High Temperature Tensile and Creep Testing Between Standard and Miniature Specimens:Applicability and Limits

This study concerns the quasi-static and time-dependent mechanical behavior obtained via the miniaturized electro-thermal mechanical testing (ETMT) approach for single crystal (SX) and conventional cast Mar-M-247 superalloy. The experimental outcome was benchmarked against standardized testing procedures. It is found that tensile yielding behavior can be captured accurately by the ETMT approach up to 1100 ºC, provided the appropriate type of thermocouple (T/C) is chosen. Furthermore, creep rupture behavior is underestimated by the miniaturized set-up. High repeatability of the rupture time was obtained for the SX case, whereas a significant scatter was observed for the conventional cast case. The discrepancies are assessed in detail; discussion centers around analytical and practical considerations, such as temperature uncertainty due to parasitic voltage and the choice of T/C, microstructural change as a result of the Joule heating, representative gauge volume, and strain rate non-linearity. Consequently, the applicability and limits of the miniaturized approach are examined critically, and improvements were suggested where appropriate

Effects of corn oil and benzyl acetate on number and size of azaserine-induced foci in the pancreas of LEW and F344 rats.

The response of LEW and F344 strain rats to the pancreatic carcinogen azaserine was compared using the size and number of azaserine-induced acidophilic acinar cell foci and nodules as parameters in a 4-month experiment. A second experiment compared the effect of corn oil intake by gavage and dietary routes on the growth of azaserine-induced pancreatic lesions in LEW rats. A third experiment tested the activity of benzyl acetate in regard to its ability to induce acinar cell foci or to promote the growth of such foci in azaserine-treated rats. The results showed that equivalent doses of azaserine induce two to seven times more foci in LEW than in F344 rats, and that LEW rats have a higher incidence of "spontaneous" foci than F344 rats. Azaserine-treated LEW rats that were given 5 mL corn oil/kg body weight 5 days per week by gavage developed more acinar cell foci than rats fed a basal diet (chow). Addition of an equivalent amount of corn oil to chow had a similar effect of enhancing the development of foci. Rats of neither strain developed acinar cell foci when benzyl acetate was given by gavage or in the diet nor was there evidence that benzyl acetate has a significant effect on the development of foci in azaserine-treated rats. These studies also demonstrate that the azaserine/rat model of pancreatic carcinogenesis which was developed in LEW rats can be adapted for use with F344 rats

Chemopreventive Effect of Oltipraz on AFB1-Induced Hepatocarcinogenesis in Tree Shrew Model

Hepatocellular carcinoma (HCC) is one of the major cancers in the world with a mortality of more than 250 000 cases yearly. More than 137 000 cases of HCC were diagnosed each year in China, which acount approximately for more than 40 percent of the total number in the world. HCC has become the second major cause of death for cancer in China since 1990, and its annual mortality is expected to be 21.2 cases per 100 000 population in the year 2000. Even though progresses have been achieved for HCC diagnosis and treat ment, its 5-year mortality is still higher than 95 percent. The prevalence of HCC is quite different among different areas around the world. It is considerably high in South-East Asia and sub- Saharan Africa, particularly in some southern and eastern regions inside China such as Fusui County in Guangxi Zhuang Autonomous Region and Qidong City in Jiangsu Province. The standardized incidence of HCC in these high-risk regions may exceed 100 cases per 100000 of population. The obvious difference in geographic distribution of HCC indicates that there must be environmental factors for its pathogenesis

POSTURAL ALTERATIONS IN PATIENTS WITH SUBACROMIAL IMPINGEMENT SYNDROME.

BackgroundAn aberrant upper body posture has been proposed as one of the etiological factors contributing to the development of subacromial impingement syndrome (SAIS). Clinicians have translated this supposition into assessment and rehabilitation programs despite insufficient and conflicting evidence to support this approach.PurposeThe purpose of this study was to compare several postural variables between the SAIS patients and asymptomatic healthy controls.Study designCase-Control Study.MethodsA total of 75 participants including 39 patients (20 females; 19 males) and 36 healthy controls (15 females; 21 males) participated in the study. Study evaluated several postural variables including forward head posture (FHP), forward shoulder posture (FSP), thoracic kyphosis index (TKI), scapular index (SI), normalized scapular protraction (NSP), and the lateral scapular slide test (LSST). The variables were compared between patient and control groups according to sex.ResultsSignificant differences were observed in the female patients compared to asymptomatic controls for the FHP (49.38 + 9.6o vs 55.5o+8.38, p=0.03), FSP (45.58 + 10.1o vs 53.68 + 7.08, p=0.02), and LSST in third position (10.2 + 2.1cm vs 11.5 + 0.7cm, p=0.01). Male patients showed a significant difference only in the FSP compared to controls (61.9o+9.4o vs 49.78 + 9.28, pConclusionsWhile inadequate data on the relationship between dysfunctional posture and SAIS has led to broad variations in current rehabilitation strategies, the results of the present study revealed different patterns of postural aberrations in female and male patients with SAIS. This clarifies the need to develop individualized or sex-specific approaches for assessing posture in men and women with SAIS and rehabilitation programs based on the assessment results.Level of evidence3b

Subacromial Impingement Syndrome: An Electromyographic Study of Shoulder Girdle Muscle Fatigue

Muscle fatigue affecting glenohumeral and/or scapular muscles is suggested as one of the 25 contributing factors to the development of subacromial impingement syndrome (SAIS). 26 Nonetheless, the fatigability of shoulder girdle muscles in association with the pathomechanics 27 of SAIS has not been reported. This study aimed to measure and compare fatigue progression 28 within the shoulder girdle musculature of patients and healthy controls. 75 participants 29 including 39 patients (20 females; 19 males) and 36 healthy controls (15 females; 21 males) 30 participated in the study. Study evaluated the progression of muscle fatigue in 15 shoulder 31 girdle muscles by means of surface and fine-wire EMG during submaximal contraction of four 32 distinct movements (abduction, flexion, internal and external rotation). Shoulder strength, 33 subjective pain experience (McGill Pain Questionnaire), and psychological status (Hospital 34 Anxiety and Depression Scale) were also assessed. The results were compared between patient 35 and control groups according to the gender. Despite marked fatigue observed in the majority 36 of muscles particularly during flexion and abduction at 90°, overall results indicated a lower 37 tendency of fatigue progression in the impingement group across the tests (0.05< p <0.05). 38 Shoulder Strength, pain experience, and psychological status were significantly different 39 between the two groups (P<0.05). Lower tendency to fatigue progression in the impingement 40 group can be attributed to the presence of fear avoidance and pain-related muscle inhibition, 41 which in turn lead to adaptations in motor programme to reduce muscle recruitment and 42 activation. The significantly higher levels of pain experience and anxiety/depression in the 43 impingement group further support this proposition

The comparison of grey-scale ultrasonic and clinical features of hepatoblastoma and hepatocellular carcinoma in children: a retrospective study for ten years

<p>Abstract</p> <p>Background</p> <p>Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first and the second most common pediatric malignant liver tumors. The purpose of this study was to evaluate the combined use of the ultrasound examination and the assessment of the patients' clinical features for differentiating HBL from HCC in children.</p> <p>Methods</p> <p>Thirty cases of the confirmed HBL and 12 cases of the confirmed HCC in children under the age of 15 years were enrolled into our study. They were divided into the HBL group and the HCC group according to the histological types of the tumors. The ultrasonic features and the clinical manifestations of the two groups were retrospectively analyzed, with an emphasis on the following parameters: onset age, gender (male/female) ratio, positive epatitis-B-surface-antigen (HBV), alpha-fetoprotein increase, and echo features including septa, calcification and liquefaction within the tumors.</p> <p>Results</p> <p>Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001). The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02). When a combination of the liquefaction, septa, negative HBV and onset age smaller than 5 years was used in the evaluation, the sensitivity was raised to 90%, the accuracy was raised to 88%, and the negative predictive value was raised to 73%.</p> <p>Conclusion</p> <p>Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.</p

DebriSat - A Planned Laboratory-Based Satellite Impact Experiment for Breakup Fragment Characterizations

The goal of the DebriSat project is to characterize fragments generated by a hypervelocity collision involving a modern satellite in low Earth orbit (LEO). The DebriSat project will update and expand upon the information obtained in the 1992 Satellite Orbital Debris Characterization Impact Test (SOCIT), which characterized the breakup of a 1960 s US Navy Transit satellite. There are three phases to this project: the design and fabrication of DebriSat - an engineering model representing a modern, 60-cm/50-kg class LEO satellite; conduction of a laboratory-based hypervelocity impact to catastrophically break up the satellite; and characterization of the properties of breakup fragments down to 2 mm in size. The data obtained, including fragment size, area-to-mass ratio, density, shape, material composition, optical properties, and radar cross-section distributions, will be used to supplement the DoD s and NASA s satellite breakup models to better describe the breakup outcome of a modern satellite