The Mutual Orbit, Mass, and Density of Transneptunian Binary Gknhmdm (229762 2007 UK126)

We present high spatial resolution images of the binary transneptunian object Gkn'hmdm (229762 2007 UK126) obtained with the Hubble Space Telescope and with the Keck observatory on Mauna Kea to determine the orbit of G' hG' h, the much smaller and redder satellite. G' h orbits in a prograde sense, on a circular or near-circular orbit with a period of 11.3 days and a semimajor axis of 6000 km. Tidal evolution is expected to be slow, so it is likely that the system formed already in a low-eccentricity configuration, and possibly also with the orbit plane of the satellite in or close to the plane of Gkn'hmdm's equator. From the orbital parameters we can compute the system mass to be 1.4 10(exp 20) kg. Combined with estimates of the size of Gkn'hmdm from thermal observations and stellar occultations, we can estimate the bulk density as about 1 g cm(exp 3). This low density is indicative of an ice-rich composition, unless there is substantial internal porosity. We consider the hypothesis that the composition is not unusually ice-rich compared with larger TNOs and comet nuclei, and instead the porosity is high, suggesting that mid-sized objects in the 400 to 1000 km diameter range mark the transition between small, porous objects and larger objects that have collapsed their internal void space as a result of their much higher internal pressures and temperatures

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.

Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a 'DNA-strand break sensor', which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in response to DNA-breaks and potentiate the cytotoxicity of DNA damaging agents. However, with the recent discoveries of PARP-2, which has a similar DNA-damage dependent catalytic activity, and additional members containing the 'PARP catalytic' signature, the isoform selectivity and resultant pharmacological effects of existing inhibitors are brought into question. We present here the crystal structure of the catalytic fragment of murine PARP-2, at 2.8 A resolution, and compare this to the catalytic fragment of PARP-1, with an emphasis on providing a possible framework for rational drug design in order to develop future isoform-specific inhibitors

The influence of regional feedbacks on circulation sensitivity

Weakening of the tropical overturning circulation in a warmer world is a robust feature in climate models. Here an idealized representation of ocean heat flux drives a Walker cell in an aquaplanet simulation. A goal of the study is to assess the influence of the Walker circulation on the magnitude and structure of climate feedbacks, as well as to global sensitivity. We compare two CO_2 perturbation experiments, one with and one without a Walker circulation, to isolate the differences attributable to tropical circulation and associated zonal asymmetries. For an imposed Walker circulation, the subtropical shortwave cloud feedback is reduced, which manifests as a weaker tropical-subtropical anomalous energy gradient and consequently a weaker slow down of the Hadley circulation, relative to the case without a Walker circulation. By focusing on the coupled feedback circulation system, these results offer insights into understanding changes in atmospheric circulation and hence the hydrological cycle under global warming

Quantum oscillations of self-dual Abrikosov-Nielsen-Olesen vortices

The mass shift induced by one-loop quantum fluctuations on self-dual ANO vortices is computed using heat kernel/generalized zeta function regularization methods. The quantum masses of super-imposed multi-vortices with vorticity lower than five are given. The case of two separate vortices with a quantum of magnetic flux is also discussed.Comment: RevTex, 13 pages, 4 figures, 7 tables. Minor corrections. Version to appear in Physical Review

Type II critical phenomena of neutron star collapse

We investigate spherically-symmetric, general relativistic systems of collapsing perfect fluid distributions. We consider neutron star models that are driven to collapse by the addition of an initially "in-going" velocity profile to the nominally static star solution. The neutron star models we use are Tolman-Oppenheimer-Volkoff solutions with an initially isentropic, gamma-law equation of state. The initial values of 1) the amplitude of the velocity profile, and 2) the central density of the star, span a parameter space, and we focus only on that region that gives rise to Type II critical behavior, wherein black holes of arbitrarily small mass can be formed. In contrast to previously published work, we find that--for a specific value of the adiabatic index (Gamma = 2)--the observed Type II critical solution has approximately the same scaling exponent as that calculated for an ultrarelativistic fluid of the same index. Further, we find that the critical solution computed using the ideal-gas equations of state asymptotes to the ultrarelativistic critical solution.Comment: 24 pages, 22 figures, RevTeX 4, submitted to Phys. Rev.

Including Systematic Uncertainties in Confidence Interval Construction for Poisson Statistics

One way to incorporate systematic uncertainties into the calculation of confidence intervals is by integrating over probability density functions parametrizing the uncertainties. In this note we present a development of this method which takes into account uncertainties in the prediction of background processes, uncertainties in the signal detection efficiency and background efficiency and allows for a correlation between the signal and background detection efficiencies. We implement this method with the Feldman & Cousins unified approach with and without conditioning. We present studies of coverage for the Feldman & Cousins and Neyman ordering schemes. In particular, we present two different types of coverage tests for the case where systematic uncertainties are included. To illustrate the method we show the relative effect of including systematic uncertainties the case of dark matter search as performed by modern neutrino tel escopes.Comment: 23 pages, 10 figures, replaced to match published versio

Paramaterizations of inclusive cross sections for pion production in proton-proton collisions. II. Comparison to new data

A set of new, precise data have recently been made available by the NA49 collaboration for charged pion production in proton-proton and proton-Carbon reactions at 158 GeV. The current paper compares this new data to five currently available arithmetic parameterizations. Although a precise fit is not expected, two of the parameterizations do not work very well but the other three are able to provide a moderately good, but not precise fit to the proton-proton data. The best two of these three parameterizations are scaled to the proton-Carbon data and again provide a moderately good, but not precise fit.Comment: 11 pages, 13 figures, Accepted for publication in Physical Review

Step Position Distributions and the Pairwise Einstein Model for Steps on Crystal Surfaces

The Pairwise Einstein Model (PEM) of steps not only justifies the use of the Generalized Wigner Distribution (GWD) for Terrace Width Distributions (TWDs), it also predicts a specific form for the Step Position Distribution (SPD), i.e., the probability density function for the fluctuations of a step about its average position. The predicted form of the SPD is well approximated by a Gaussian with a finite variance. However, the variance of the SPD measured from either real surfaces or Monte Carlo simulations depends on $\Delta y$, the length of step over which it is calculated, with the measured variance diverging in the limit $\Delta y \to \infty$. As a result, a length scale $L_{\rm W}$ can be defined as the value of $\Delta y$ at which the measured and theoretical SPDs agree. Monte Carlo simulations of the terrace-step-kink model indicate that $L_{\rm W} \approx 14.2 \xi_Q$, where $\xi_Q$ is the correlation length in the direction parallel to the steps, independent of the strength of the step-step repulsion. $L_{\rm W}$ can also be understood as the length over which a {\em single} terrace must be sampled for the TWD to bear a "reasonable" resemblence to the GWD.Comment: 4 pages, 3 figure