Penggunaan Model Kooperatif Tipe Think Pair Share Berbantuan Multimedia Terhadap Hasil Belajar Dan Respon Siswa

This research is intended to know the difference between learning outcome and students\u27 response in the tenth grade students of SMA Negeri 1 Bengkayang on redox reaction material by using cooperative model of Think Pair Share (TPS) technique with the absence of multimedia and students\u27 response toward learning. This research is conducted in quasi-experimental form by "Non Equivalent Control Group Design” with measurement technique by learning outcome test and indirect communication in students\u27 response questioner form. Based on the analysis by using U Mann Whitney test, it showed that there is different achievement of learning outcome in the experimental and the control class. From the data of students\u27 response toward learning, at the end, it is known that the statement presentage is on high criterion level at 80.43%

Profil Kinerja Siswa Melalui Penerapan Model Pembelajaran Predict–observe–explain (Poe) Pada Materi Hidrolisis Garam

. The purpose of this research is to describe the student performance from class XI SMAN 1 Sungai Raya through the implementation of model predict-observe-explain on hydrolysis salt. Determine of research samples using purposive sampling. Pre-experiment method was used in this research and one shot case study framework. The technique of collecting data used direct observation and communication. Student performance action used individual assessment and performance product used group assessment. The results of data analysis showed that the performance actions of students at the stage of discussion, presentation and observation are in the category of competent. The performance product of students to making practical reports and prediction are in the category of incompetent. Based on data analysis, POE model can describe student performance action in competent category and performance product in incompetent category

Pengaruh Metode Sq3r terhadap Hasil Belajar dan Minat Membaca di Man 1 Pontianak

The aim of this research are defining the difference in learning outcomes and interest in reading among students who are taught by the teaching methods SQ3R with the students taught using conventional teaching methods as well as to determine the effect of the application of learning methods SQ3R on colloidal material grade XI MAN 1 Pontianak. Samples were selected based simple random sampling techniques, a class XI IPA 3 as an experimental class and class XI IPA 2 as the control class. Forms of research is quasi experiment) with the design is Nonequivalent Control Group Design. Data collection tool used consisted of test results and questionnaire study reading interests. Results of the data analysis shows that there are differences in learning outcomes and interest in reading among the students taught using instructional methods SQ3R with the students taught using conventional teaching methods. The value of effect size showed that the learning method SQ3R effect of 26.12% of the student learning outcomes

The ALTO project at IPN Orsay

In order to probe neutron rich radioactive noble gases produced by photo-fission, a PARRNe1 experiment (Production d'Atomes Radioactifs Riches en Neutrons) has been carried out at CERN. The incident electron beam of 50 MeV was delivered by the LIL machine: LEP Injector Linac. The experiment allowed to compare under the same conditions two production methods of radioactive noble gases: fission induced by fast neutrons and photo-fission. The obtained results show that the use of the electrons is a promising mode to get intense neutron rich ion beams. Thereafter, the success of this photo-fission experiment, a conceptual design for the installation at IPN Orsay of a 50 MeV electron accelerator close to the PARRNe-2 device has been worked out: ALTO Project. This work has started within a collaboration between IPNO, LAL and CERN groups.Comment: 14 pages, pdf file, International School-Seminar on Heavy-Ion Physics 7 (2002

Pengaruh Model Starter Eksperimen terhadap Aktivitas dan Hasil Belajar Siswa pada Materi Koloid

The aims of this research was to determine difference in activity and learning outcomes of students who are taught using a model of Starter Experiment with the students taught using the conventional methods and determine the influence of Starter Experiment model of the learning outcomes of students of class XI SMA Kemala Bhayangkari in the material colloid. The from of research was a quasi-experimental with nonequivalent control group design. The samples was determine on samping technique that selected class XI MIA 2 as an experiment class and Class XI MIA 1 as the control classes. Research instrument are a test of learning outcomes, observation sheet of student activity, and interview. The results of data analysis showed that there was difference in activity and learning outcomes between students who were taught using Starter experiment model with students who were taught using conventional methods. The use of Starter Experiment model to the material of colloid influence of 22.24% (ES = 0.59) toward the improving student learning outcomes

T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers

Introduction: Lymphocyte infiltration (LI) is often seen in breast cancer but its importance remains controversial. A positive correlation of human epidermal growth factor receptor 2 (HER2) amplification and LI has been described, which was associated with a more favorable outcome. However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor. Methods: Affymetrix HG-U133A microarray data of 1,781 primary breast cancer samples from 12 datasets were included. The correlation of immune system-related metagenes with different immune cells, clinical parameters, and survival was analyzed. Results: A large cluster of nearly 600 genes with functions in immune cells was consistently obtained in all datasets. Seven robust metagenes from this cluster can act as surrogate markers for the amount of different immune cell types in the breast cancer sample. An IgG metagene as a marker for B cells had no significant prognostic value. In contrast, a strong positive prognostic value for the T-cell surrogate marker (lymphocyte-specific kinase (LCK) metagene) was observed among all estrogen receptor (ER)-negative tumors and those ER-positive tumors with a HER2 overexpression. Moreover ER-negative tumors with high expression of both IgG and LCK metagenes seem to respond better to neoadjuvant chemotherapy. Conclusions: Precise definitions of the specific subtypes of immune cells in the tumor can be accomplished from microarray data. These surrogate markers define subgroups of tumors with different prognosis. Importantly, all known prognostic gene signatures uniformly assign poor prognosis to all ER-negative tumors. In contrast, the LCK metagene actually separates the ER-negative group into better or worse prognosis

The proteome of extracellular vesicles released by clastic cells differs based on their substrate

Extracellular vesicles (EVs) from osteoclasts are important regulators in intercellular communication. Here, we investigated the proteome of EVs from clastic cells plated on plastic (clasts), bone (osteoclasts) and dentin (odontoclasts) by two-dimensional high performance liquid chromatography mass spectrometry seeking differences attributable to distinct mineralized matrices. A total of 1,952 proteins were identified. Of the 500 most abundant proteins in EVs, osteoclast and odontoclast EVs were 83.3% identical, while clasts shared 70.7% of the proteins with osteoclasts and 74.2% of proteins with odontoclasts. For each protein, the differences between the total ion count values were mapped to an expression ratio histogram (Z-score) in order to detect proteins differentially expressed. Stabilin-1 and macrophage mannose receptor-1 were significantly-enriched in EVs from odontoclasts compared with osteoclasts (Z = 2.45, Z = 3.34) and clasts (Z = 13.86, Z = 1.81) and were abundant in odontoclast EVs. Numerous less abundant proteins were differentially-enriched. Subunits of known protein complexes were abundant in clastic EVs, and were present at levels consistent with them being in assembled protein complexes. These included the proteasome, COP1, COP9, the T complex and a novel sub-complex of vacuolar H+ -ATPase (V-ATPase), which included the (pro) renin receptor. The (pro) renin receptor was immunoprecipitated using an anti-E-subunit antibody from detergent-solubilized EVs, supporting the idea that the V-ATPase subunits present were in the same protein complex. We conclude that the protein composition of EVs released by clastic cells changes based on the substrate. Clastic EVs are enriched in various protein complexes including a previously undescribed VATPase sub-complex

From Inflammation to the Onset of Fibrosis through A2A Receptors in Kidneys from Deceased Donors.

Pretransplant graft inflammation could be involved in the worse prognosis of deceased donor (DD) kidney transplants. A2A adenosine receptor (A2AR) can stimulate anti-inflammatory M2 macrophages, leading to fibrosis if injury and inflammation persist. Pre-implantation biopsies of kidney donors (47 DD and 21 living donors (LD)) were used to analyze expression levels and activated intracellular pathways related to inflammatory and pro-fibrotic processes. A2AR expression and PKA pathway were enhanced in DD kidneys. A2AR gene expression correlated with TGF-β1 and other profibrotic markers, as well as CD163, C/EBPβ, and Col1A1, which are highly expressed in DD kidneys. TNF-α mRNA levels correlated with profibrotic and anti-inflammatory factors such as TGF-β1 and A2AR. Experiments with THP-1 cells point to the involvement of the TNF-α/NF-κB pathway in the up-regulation of A2AR, which induces the M2 phenotype increasing CD163 and TGF-β1 expression. In DD kidneys, the TNF-α/NF-κB pathway could be involved in the increase of A2AR expression, which would activate the PKA-CREB axis, inducing the macrophage M2 phenotype, TGF-β1 production, and ultimately, fibrosis. Thus, in inflamed DD kidneys, an increase in A2AR expression is associated with the onset of fibrosis, which may contribute to graft dysfunction and prognostic differences between DD and LD transplants