Condensate Fraction of a Two-Dimensional Attractive Fermi Gas

We investigate the Bose-Einstein condensation of fermionic pairs in a two-dimensional uniform two-component Fermi superfluid obtaining an explicit formula for the condensate density as a function of the chemical potential and the energy gap. By using the mean-field extended BCS theory, we analyze, as a function of the bound-state energy, the off-diagonal long-range order in the crossover from the Bardeen-Cooper-Schrieffer (BCS) state of weakly-bound Cooper pairs to the Bose-Einstein Condensate (BEC) of strongly-bound molecular dimers.Comment: 4 pages, 2 figures, accepted for publication in Phys. Rev.

Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy

Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5 degrees nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (-0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

Cancer cells possess traits reminiscent of those ascribed to normal stem cells. It is unclear, however, whether these phenotypic similarities reflect the activity of common molecular pathways. Here, we analyze the enrichment patterns of gene sets associated with embryonic stem (ES) cell identity in the expression profiles of various human tumor types. We find that histologically poorly differentiated tumors show preferential overexpression of genes normally enriched in ES cells, combined with preferential repression of Polycomb-regulated genes. Moreover, activation targets of Nanog, Oct4, Sox2 and c-Myc are more frequently overexpressed in poorly differentiated tumors than in well-differentiated tumors. In breast cancers, this ES-like signature is associated with high-grade estrogen receptor (ER)-negative tumors, often of the basal-like subtype, and with poor clinical outcome. The ES signature is also present in poorly differentiated glioblastomas and bladder carcinomas. We identify a subset of ES cell-associated transcription regulators that are highly expressed in poorly differentiated tumors. Our results reveal a previously unknown link between genes associated with ES cell identity and the histopathological traits of tumors and support the possibility that these genes contribute to stem cell–like phenotypes shown by many tumors

Ionic liquids at electrified interfaces

Until recently, “room-temperature” (<100–150 °C) liquid-state electrochemistry was mostly electrochemistry of diluted electrolytes(1)–(4) where dissolved salt ions were surrounded by a considerable amount of solvent molecules. Highly concentrated liquid electrolytes were mostly considered in the narrow (albeit important) niche of high-temperature electrochemistry of molten inorganic salts(5-9) and in the even narrower niche of “first-generation” room temperature ionic liquids, RTILs (such as chloro-aluminates and alkylammonium nitrates).(10-14) The situation has changed dramatically in the 2000s after the discovery of new moisture- and temperature-stable RTILs.(15, 16) These days, the “later generation” RTILs attracted wide attention within the electrochemical community.(17-31) Indeed, RTILs, as a class of compounds, possess a unique combination of properties (high charge density, electrochemical stability, low/negligible volatility, tunable polarity, etc.) that make them very attractive substances from fundamental and application points of view.(32-38) Most importantly, they can mix with each other in “cocktails” of one’s choice to acquire the desired properties (e.g., wider temperature range of the liquid phase(39, 40)) and can serve as almost “universal” solvents.(37, 41, 42) It is worth noting here one of the advantages of RTILs as compared to their high-temperature molten salt (HTMS)(43) “sister-systems”.(44) In RTILs the dissolved molecules are not imbedded in a harsh high temperature environment which could be destructive for many classes of fragile (organic) molecules

Binary orbit and disks properties of the RW Aur system using ALMA observations

The dynamical interactions between young binaries can perturb the material distribution of their circumstellar disks, and modify the planet formation process. In order to constrain the impact and nature of the binary interaction in the RW Aur system (bound or unbound), we analyzed the circumstellar material at 1.3 mm wavelengths, as observed at multiple epochs by ALMA. We analyzed the disk properties through parametric visibility modeling, and we used this information to constrain the dust morphology and the binary orbital period. We imaged the dust continuum emission of RW Aur with a resolution of 3 au, and we find that the radius enclosing 90% of the flux (R90%) is 19 au and 14 au for RW Aur A and B, respectively. By modeling the relative distance of the disks at each epoch, we find a consistent trend of movement for the disk of RW Aur B moving away from the disk of RW Aur A at an approximate rate of 3 mas/yr (about 0.5 au/yr in sky-projected distance). By combining ALMA astrometry, historical astrometry, and the dynamical masses of each star, we constrain the RW Aur binary stars to be most likely in a high-eccentricity elliptical orbit with a clockwise prograde orientation relative to RW Aur A, although low-eccentricity hyperbolic orbits are not ruled out by the astrometry. Our analysis does not exclude the possibility of a disk collision during the last interaction, which occurred $295_{-74}^{+21}$ yr ago relative to beginning of 2024. Evidence for the close interaction is found in a tentative warp of 6 deg in the inner 3 au of the disk of RW Aur A, in the brightness temperature of both disks, and in the morphology of the gas emission. A narrow ring that peaks at 6 au around RW Aur B is suggestive of captured material from the disk around RW Aur A.Accepted in A&A. All self-calibrated data and products are publicly available in https://doi.org/10.5281/zenodo.12825068 . Short video summary in https://youtu.be/IOjEW8Vrj9

Human genetic selection on the MTHFR 677C>T polymorphism

<p>Abstract</p> <p>Background</p> <p>The prevalence of genotypes of the 677C>T polymorphism for the MTHFR gene varies among humans. In previous studies, we found changes in the genotypic frequencies of this polymorphism in populations of different ages, suggesting that this could be caused by an increase in the intake of folate and multivitamins by women during the periconceptional period. The aim was to analyze changes in the allelic frequencies of this polymorphism in a Spanish population, including samples from spontaneous abortions (SA).</p> <p>Methods</p> <p>A total of 1305 subjects born in the 20th century were genotyped for the 677C>T polymorphism using allele specific real-time PCR with Taqman^®probes. A section of our population (n = 276) born in 1980–1989 was compared with fetal samples (n = 344) from SA of unknown etiology from the same period.</p> <p>Results</p> <p>An increase in the frequency of the T allele (0.38 vs 0.47; p < 0.001) and of the TT genotype (0.14 vs 0.24; p < 0.001) in subjects born in the last quarter of the century was observed. In the 1980–1989 period, the results show that the frequency of the wild type genotype (CC) is about tenfold lower in the SA samples than in the controls (0.03 vs 0.33; p < 0.001) and that the frequency of the TT genotype increases in the controls (0.19 to 0.27) and in the SA samples (0.20 to 0.33 (p < 0.01)); r = 0.98.</p> <p>Conclusion</p> <p>Selection in favor of the T allele has been detected. This selection could be due to the increased fetal viability in early stages of embryonic development, as is deduced by the increase of mutants in both living and SA populations.</p

The ALMA Survey of Gas Evolution of PROtoplanetary Disks (AGE-PRO). IV. Dust and Gas Disk Properties in the Upper Scorpius Star-forming Region

The Atacama Large Millimeter/submillimeter Array (ALMA) large program AGE-PRO explores protoplanetary disk evolution by studying gas and dust across various ages. This work focuses on 10 evolved disks in Upper Scorpius, observed in dust continuum emission, CO and its isotopologues, and N2H+ with ALMA Bands 6 and 7. Disk radii, from the radial location enclosing 68% of the flux, are comparable to those in the younger Lupus region for both gas and dust tracers. However, solid masses are about an order of magnitude below those in Lupus and Ophiuchus, while the dust spectral index suggests some level of dust evolution. These empirical findings align with a combination of radial drift, dust trapping, and grain growth into larger bodies. A moderate correlation between CO and continuum fluxes suggests a link between gas and dust content, through the increased scatter compared to younger regions, possibly due to age variations, gas-to-dust ratio differences, or CO depletion. Additionally, the correlation between C18O and N2H+ fluxes observed in Lupus persists in Upper Scorpius, indicating a relatively stable CO gas abundance over the Class II stage of disk evolution. In conclusion, the AGE-PRO survey of Upper Scorpius disks reveals intriguing trends in disk evolution. The findings point toward potential gas evolution and the presence of dust traps in these older disks. Future high-resolution observations are needed to confirm these possibilities and further refine our understanding of disk evolution and planet formation in older environments

The ALMA Survey of Gas Evolution of PROtoplanetary Disks (AGE-PRO). III. Dust and Gas Disk Properties in the Lupus Star-forming Region

We present Band 6 and Band 7 observations of 10 Lupus disks around M3-K6 stars from the Atacama Large Millimeter/submillimeter Array survey of Gas Evolution in PROtoplanetary disks (AGE-PRO) Large Program. In addition to continuum emission in both bands, our Band 6 setup covers the 12CO, 13CO, and C18O J = 2–1 lines, while our Band 7 setup covers the N2H+ J = 3–2 line. All of our sources are detected in 12CO and 13CO; seven out of ten are detected in C18O; and three are detected in N2H+. We find strong correlations between the CO isotopologue line fluxes and the continuum flux densities. With the exception of one disk, we also identify a strong correlation between the C18O J = 2–1 and N2H+ J = 3–2 fluxes, indicating similar CO abundances across this sample. For the two sources with well-resolved continuum and 12CO J = 2–1 images, we find that their gas-to-dust size ratio is consistent with the median value of ∼2 inferred from a larger sample of Lupus disks. We derive dust disk masses from continuum flux densities. We estimate gas disk masses by comparing C18O J = 2–1 line fluxes with those predicted by the limited grid of self-consistent disk models of M. Ruaud et al. A comparison of these mass estimates with those derived by L. Trapman et al., using a combination of CO isotopologue and N2H+ line emission, shows that the masses are consistent with each other. Some discrepancies appear for small and faint disks, but they are still within the uncertainties. Both methods find gas disk masses increase with dust disk masses, and gas-to-dust mass ratios are between 10 and 100 in the AGE-PRO Lupus sample

Emery-Dreifuss muscular dystrophy Type 1 is associated with a high risk of malignant ventricular arrhythmias and end-stage heart failure

\ua9 2023 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology.Background and Aims: Emery-Dreifuss muscular dystrophy (EDMD) is caused by variants in EMD (EDMD1) and LMNA (EDMD2). Cardiac conduction defects and atrial arrhythmia are common to both, but LMNA variants also cause end-stage heart failure (ESHF) and malignant ventricular arrhythmia (MVA). This study aimed to better characterize the cardiac complications of EMD variants. Methods: Consecutively referred EMD variant-carriers were retrospectively recruited from 12 international cardiomyopathy units. MVA and ESHF incidences in male and female variant-carriers were determined. Male EMD variant-carriers with a cardiac phenotype at baseline (EMDCARDIAC) were compared with consecutively recruited male LMNA variant-carriers with a cardiac phenotype at baseline (LMNACARDIAC). Results: Longitudinal follow-up data were available for 38 male and 21 female EMD variant-carriers [mean (SD) ages 33.4 (13.3) and 43.3 (16.8) years, respectively]. Nine (23.7%) males developed MVA and five (13.2%) developed ESHF during a median (inter-quartile range) follow-up of 65.0 (24.3-109.5) months. No female EMD variant-carrier had MVA or ESHF, but nine (42.8%) developed a cardiac phenotype at a median (inter-quartile range) age of 58.6 (53.2-60.4) years. Incidence rates for MVA were similar for EMDCARDIAC and LMNACARDIAC (4.8 and 6.6 per 100 person-years, respectively; log-rank P =. 49). Incidence rates for ESHF were 2.4 and 5.9 per 100 person-years for EMDCARDIAC and LMNACARDIAC, respectively (log-rank P =. 09). Conclusions: Male EMD variant-carriers have a risk of progressive heart failure and ventricular arrhythmias similar to that of male LMNA variant-carriers. Early implantable cardioverter defibrillator implantation and heart failure drug therapy should be considered in male EMD variant-carriers with cardiac disease