Gender differences in human immunodeficiency virus (HIV) RNA and CD4 cell counts among new entrants to HIV care

ABSTRACTClinic database extraction identified 806 new entrants to human immunodeficiency virus (HIV) care in Cleveland, OH, USA. At entry, women had higherCD4 counts and lower HIVRNAlevels than men (mean, 388 vs. 310 cells/µL, and 8.94 × 104 vs. 1.27 × 105 copies/mL, respectively), but the proportion of entrants with category C illnesses, category B conditions, sexually transmitted diseases and CD4 counts < 200 µL did not differ between genders. Hepatitis B seroprevalence was higher in men (8.7% vs. 0.6%), but there was no difference in hepatitis C prevalence. Whether women in Cleveland seek HIV care earlier, or whether early markers of HIV disease differ between the genders, remains to be determined

Frequency Tuned Planar Inverted F Antenna with L Shaped Slit Design for Wide Frequency Range.

yesA frequency tuned antenna has been designed to meet the coverage requirements of the DCS, PCS, UMTS and WLAN bands. The antenna consists of a main patch, and a planar inverted L (PIL) slot. The radiator patch is fed, and shorted, using simple feed lines with broadband characteristics. The handset represents the finite ground plane, and a varactor diode is mounted across the middle of the slot for tuning purposes. Initial tuning was obtained by placing lumped capacitors, instead of the varactor, over the radiator. Good agreement is obtained between the predicted and measured input return loss, gain and radiation pattern over the tuned frequency range.MSCR

Strategies and options for increasing and sustaining fisheries and aquaculture production to benefit poorer households in Asia [PDF in letter standard]

The last three decades have wi tnessed dramatic changes in the structure of supply and demand for fish, especially in Asia. This WorldFish research study sponsored by the Asian Development Bank focussed on nine developing countries û Bangladesh, China, India, Indonesia, Malaysia, the Philippines, Sri Lanka, Thailand, and Vietnam, all active players in the transformation of global fish supply and demand. The study, broken into five components and reported here, considered: 1) the profile of key aquaculture technologies and fishing practices; 2) analysis of policies, institutions and support services; 3) socioeconomic profile of major stakeholders in the fisheries sector; 4) projections of fish demand and supply in the nine Asian countries; and 5) formulation of national action plans based on the findings and recommendations of the study.Research, Fisheries, Economic analysis, Aquaculture, Fish consumption, Trade, Policies, Socioeconomic aspects, Technology, Fishery products, Asia, China, People's Rep., Bangladesh, India, Indonesia, Malaysia, Philippines, Malaysia, Sri Lanka, Thailand, Vietnam,

Quasilocal equilibrium condition for black ring

We use the conservation of the renormalized boundary stress-energy tensor to obtain the equilibrium condition for a general (thin or fat) black ring solution. We also investigate the role of the spatial stress in the thermodynamics of deformation within the quasilocal formalism of Brown and York and discuss the relation with other methods. In particular, we discuss the quantum statistical relation for the unbalanced black ring solution.Comment: v2: refs. added, matches the published versio

Field-induced segregation of ferromagnetic nano-domains in Pr0.5_{0.5}Sr0.5_{0.5}MnO3_3, detected by 55^{55}Mn NMR

The antiferromagnetic manganite Pr$_{0.5}$Sr$_{0.5}$MnO$_3$ was investigated at low temperature by means of magnetometry and $^{55}$Mn NMR. A field-induced transition to a ferromagnetic state is detected by magnetization measurements at a threshold field of a few tesla. NMR shows that the ferromagnetic phase develops from zero field by the nucleation of microscopic ferromagnetic domains, consisting of an inhomogeneous mixture of tilted and fully aligned parts. At the threshold the NMR spectrum changes discontinuously into that of a homogeneous, fully aligned, ferromagnetic state, suggesting a percolative origin for the ferromagnetic transition.Comment: Latex 2.09 language. 4 pages, 3 figures, 23 references. Submitted to physical Review

Pd-(L)1 inhibitors as monotherapy for the first-line treatment of non-small-cell lung cancer patients with high pd-l1 expression : A network meta-analysis

Altres ajuts: RocheProgrammed cell death-ligand 1 (PD-L1) has emerged as a potential biomarker for selec-tion of patients more likely to respond to immunotherapy and as a prognostic factor in non-small cell lung cancer (NSCLC). In this network meta-analysis, we aimed to evaluate the efficacy of first-line anti-PD-(L)1 monotherapy in advanced NSCLC patients with high PD-L1 expression (≥50%) compared to platinum-based chemotherapy. We also evaluated efficacy outcomes according to tumor mutational burden (TMB). To that end, we conducted a systematic review. Six clinical trials with 2111 patients were included. In head-to-head comparisons, immunotherapy showed a significant improvement in progression-free survival (PFS: HRpooled = 0.69, 95% CI: 0.52-0.90, p = 0.007), overall survival (OS: HRpooled = 0.69, 95% CI: 0.61-0.78; p < 0.001) and overall response rate (ORR) (Risk ratio (RR)pooled = 1.354, 95% CI: 1.04-1.762, p = 0.024). In the assessment of relative efficacy for PFS through indirect comparisons, pembrolizumab (results from KEYNOTE-024) ranked highest followed by cemiplimab and atezolizumab, with statistical significance determined for some of the drugs. In terms of OS, cemiplimab ranked highest followed by atezolizumab and pembrolizumab, although non-significant OS was determined for these drugs. In conclusion, PD-(L)1 inhibitor mon-otherapy improves efficacy outcomes in the first line setting of advanced NSCLC patients with high PD-L1 expression. Evaluations with longer follow up are still needed to determine the superiority of any specific drug

Associated production of H^{\pm} and W^{\mp} in high-energy e+e- collisions in the Minimal Supersymmetric Standard Model

We study the associated production of the charged Higgs boson and W^{\pm} gauge boson in high energy e+e- collisions in the Minimal Supersymmetric Standard Model (MSSM). This associated production, which first arises at the one loop level, offers the possibility of producing the charged Higgs boson at the e+e- collider with mass more than half the center-of-mass energy, when the charged Higgs pair production is kinematically forbidden. We present analytic and numerical results for the cross section for e+e- --> W+ H- in the full MSSM, taking into account the previously uncalculated contributions from supersymmetric (SUSY) particles. We find that the contributions of the SUSY particles enhance the cross section over most of SUSY parameter space, especially when the SUSY particles are light, ~200 GeV. With favorable SUSY parameters, at small tan beta, this process can yield more than ten W^{\pm}H^{\mp} events for m_{H^{\pm}} <~ 350 GeV in 500 fb-1 at a 500 GeV e+e- collider, or m_{H^{\pm}} <~ 600 GeV in 1000 fb-1 at a 1000 GeV collider. 80% left-handed polarization of the e- beam improves these reaches to m_{H^{\pm}} <~ 375 GeV and m_{H^{\pm}} <~ 670 GeV, respectively.Comment: v2: 21 pages, 9 figures, comments on Higgs search bounds and new references added, and minor changes; v3: 23 pages, 11 figures, review of literature moved from introduction to new Sec.5 and 2 plots added, references added, typos corrected; v4: bug fixed in nu nubar H0 cross section (Fig.11), version to appear in PR

Strategies and options for increasing and sustaining fisheries and aquaculture production to benefit poorer households in Asia

The last three decades have witnessed dramatic changes in the structure of supply and demand for fish, especially in Asia. This WorldFish research study sponsored by the Asian Development Bank focussed on nine developing countries – Bangladesh, China, India, Indonesia, Malaysia, the Philippines, Sri Lanka, Thailand, and Vietnam, all active players in the transformation of global fish supply and demand. The study, broken into five components and reported here, considered: 1) the profile of key aquaculture technologies and fishing practices; 2) analysis of policies, institutions and support services; 3) socioeconomic profile of major stakeholders in the fisheries sector; 4) projections of fish demand and supply in the nine Asian countries; and 5) formulation of national action plans based on the findings and recommendations of the study

IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals

AbstractThe IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections