PyMes: las grandes organizaciones del mañana, ¿ISO la solución del hoy?.

Resumen: En este articulo abordaremos el tema de la importancia que es para las empresas desarrollarse a la par de sus competidores, así como de las posibles exigencias de sus clientes, buscando las mejores herramientas de acuerdo a sus posibilidades financieras, enfocando este análisis a las PyMes (Pequeñas y Medianas Empresas). Esto se debe a que las empresas que buscan crecer dependen del compromiso de sus empleados, así como del desarrollo de sus procesos buscando su disminuir la variación. Este artículo enunciará las opciones de crecimiento de las Pymes, al buscar la certificación, estandarización y la implementación de sus procesos, con la ayuda de normas de estandarización, como la ISO 9000. Todo esto tomando en cuenta el compromiso total de su personal en todos los niveles, dado que no existir tal compromiso, para la organización solo será tomado tal proceso como un gasto innecesario y no como una inversión de crecimiento de la misma

Gamification and entrepreneurial intentions

Purpose – The purpose of this paper is to investigate how gamification can influence entrepreneurial intentions (EI) of a group of users of an online platform provided by a private company.Design/methodology/approach – A quantitative research strategy was used with a sample of 220 respondents. These respondents were tested before and after the gamification experience.Findings – Main findings support literature suggesting a clear effect of attitudes towards behaviour and perceived behavioural control on EI, in line with the theory of planned behaviour (TPB). Once the basic assumptions of TPB were confirmed, the authors tested the effects of gamification comparing before and after results. Main findings highlight an increase of these effects after the gamification experience, aligned with the self-determination theory.Practical implications – These findings suggest that gamification is able to influence entrepreneurial behaviours. This contributes to both companies and educators’ knowledge on training for EI with gamification and the use of online platforms to this effect. Recommendations are provided.Originality/value – This is the first study that investigates the impact of gamification on EI and howgamification can influence the different relationships between the antecedents of EI

Servitization strategies from customers’ perspective: the moderating role of co-creation

© 2018, Emerald Publishing Limited. Purpose: This paper aims to investigate the moderating role of co-creation in the implementation of servitization strategies in the pharmaceutical industry in a business-to-business (B-to-B) context. More specifically, this investigation explores the impact of different levels of services (base, intermediate and advanced) on servitization and on performance by using co-creation as a moderating factor. Design/methodology/approach: A research framework was developed and empirically tested in the pharmaceutical sector. Data collection was conducted through the online distribution of questionnaires. The final sample included 219 pharmacy stores, and the data were analysed using structural equation modelling. Findings: Main findings suggest that when the level of co-creation of the design of services is high, there are significant effects of servitization on firm performance. The moderating effect of co-creation is illustrated in regard to intermediate and advanced services, but results referring to the impact of intermediate services on servitization appear non-significant with a low degree of co-creation. No significant effects could be found for the impact of base services on performance and servitization for both high and low degrees of co-creation. Findings show an impact of advanced services on performance through the mediating effect of servitization when the degree of co-creation is high. Originality/value: Most research concerning servitization has been done from the perspective of manufacturers and service providers. This study adds value to the literature because it was designed from a customer’s perspective. Moreover, it contributes towards the conceptualization of the servitization research strategy and business models in a B2B context. This is accomplished through the investigation of the moderating effect of co-creation on the impact of the different levels of services on servitization and on performance

1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death

1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death L Manterola 1,12 , M Hernando-Rodr ı ́ guez 2,12 , A Ruiz 3,4 , A Apraiz 5 , O Arrizabalaga 5 , L Vello ́ n 6 , E Alberdi 3,4 , F Cavaliere 3,4 , HM Lacerda 7 , S Jimenez 8,9 , LA Parada 10 , C Matute 3,4 and JL Zugaza 4,5,11 1–42 b -Amyloid (A b 1–42 ) peptide is a key molecule involved in the development of Alzheimer’s disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve loss of neurites due to cytoskeleton alterations. However, the mechanism of A b 1–42 peptide activation of the neurodegenerative program is still poorly understood. Here, A b 1–42 peptide-induced transduction of cellular death signals through the phosphatidylinositol 3-kinase (PI3K)/ phosphoinositol-dependent kinase (PDK)/novel protein kinase C (nPKC)/Rac 1 axis is described. Furthermore, pharmacological inhibition of PDK1 and nPKC activities blocks Rac 1 activation and neuronal cell death. Our results provide insights into an unsuspected connection between PDK1, nPKCs and Rac 1 in the same signal-transduction pathway and points out nPKCs and Rac 1 as potential therapeutic targets to block the toxic effects of A b 1–42 peptide in neurons

SEU Tests Performed on the Digital Communication System for LHC Cryogenic Instrumentation

The future LHC particle accelerator will use a large number of cryogenic sensors and actuators, most of which are located inside the machine tunnel and therefore in a radiation environment. These elements will communicate through a fieldbus. This paper reports the irradiation study carried out on WorldFIP fieldbus communication system. A digital communication system based on WorldFIP fieldbus protocol has been implemented and Single Event Effects (SEE) and Total Ionizing Dose (TID) radiation tests have been performed on it

Constraints on Left-Right Symmetric and E6E_6 Superstring Models from the Number of Light Neutrino Species

Using the experimental value for the rate $R^{LEP} _{exp}=\Gamma_{inv}/\Gamma_{l\bar l}=5.942\pm 0.016$, we derive constraints on the number of light neutrino species with the invisible width method in the framework of a left-right symmetric model (LRSM) and a $E_6$ superstring model as a function of their respective mixing angles for the neutral vector gauge bosons. Using the above LEP result we get the constraints $-1.6\times 10^{-3}\leq\phi \leq 1.1\times 10^{-3}$ and $-1.3\times 10^{-2}\leq\phi_{E_6} \leq 0.4\times 10^{-2}$, which are stronger than those obtained in previous studies of these models.Comment: 9 pages, 4 figures, Submit to Modern Physics Letter

Enzymatic hydrolysis of hidrothermally pretreated agave bagasse

info:eu-repo/semantics/publishedVersio

P29 274. Indicaciones de la válvula aórtica ats 3f enable® sin sutura

La válvula ATS 3f Enable® (Medtronic) es una prótesis biológica de pericardio, diseñada como una válvula tubular para optimizar sus características hemodinámicas y disminuir el estrés.ObjetivosDescripción de las posibles indicaciones de la válvula aórtica 3f Enable® sin sutura seg?estra experiencia.Material y métodosDesde mayo de 2010 se han implantado 10 válvulas 3f Enable®, eligiendo pacientes con anillo aórtico pequeño (< 21mm) e índice de masa corporal (IMC) igual o superior a 30 o con estenosis protésica de 19mm. El tamaño de los implantes fue: 19mm: 5, 21mm: 4, y 23mm: 1. Perfil clínico de los pacientes: edad media: 72 años. Estenosis aórtica protésica: 2 pacientes. EuroSCORE medio: 6,3. El IMC medio de los pacientes con estenosis nativa: 32. En tres pacientes se realizaron injertos concomitantes.ResultadosTodos los implantes se realizaron con éxito. En dos pacientes fue necesaria la recolocación de la prótesis por insuficiencia antes de descontinuar la circulación extracorpórea. El tiempo medio de isquemia fue de 61 min, con un rango de 22–81 min. Los gradientes pico obtenidos fueron 21±6mmHg y los gradientes medios de 11±3mmHg. Un paciente requirió reintervención por insuficiencia grave debido a inframedición de la prótesis.ConclusionesLa prótesis 3f Enable® presenta un excelente comportamiento hemodinámico en pacientes con anillo aórtico pequeño y con un IMC igual o superior a 30 y consiguiente riesgo de mismatch. La estenosis protésica de 19mm también se podría considerar como indicación de implante de esta válvula

Time--Evolving Statistics of Chaotic Orbits of Conservative Maps in the Context of the Central Limit Theorem

We study chaotic orbits of conservative low--dimensional maps and present numerical results showing that the probability density functions (pdfs) of the sum of $N$ iterates in the large $N$ limit exhibit very interesting time-evolving statistics. In some cases where the chaotic layers are thin and the (positive) maximal Lyapunov exponent is small, long--lasting quasi--stationary states (QSS) are found, whose pdfs appear to converge to $q$--Gaussians associated with nonextensive statistical mechanics. More generally, however, as $N$ increases, the pdfs describe a sequence of QSS that pass from a $q$--Gaussian to an exponential shape and ultimately tend to a true Gaussian, as orbits diffuse to larger chaotic domains and the phase space dynamics becomes more uniformly ergodic.Comment: 15 pages, 14 figures, accepted for publication as a Regular Paper in the International Journal of Bifurcation and Chaos, on Jun 21, 201