A three-dimensional view of the remnant of Nova Persei 1901 (GK Per)

We present a kinematical study of the optical ejecta of GK Per. It is based on proper motions measurements of 282 knots from ~20 images spanning 25 years. Doppler-shifts are also computed for 217 knots. The combination of proper motions and radial velocities allows a unique 3-D view of the ejecta to be obtained. The main results are: (1) the outflow is a thick shell in which knots expand with a significant range of velocities, mostly between 600 and 1000 km/s; (2) kinematical ages indicate that knots have suffered only a modest deceleration since their ejection a century ago; (3) no evidence for anisotropy in the expansion rate is found; (4) velocity vectors are generally aligned along the radial direction but a symmetric pattern of non-radial velocities is also observed at specific directions; (5) the total Halpha+[NII] flux has been linearly decreasing at a rate of 2.6 % per year in the last decade. The Eastern nebular side is fading at a slower rate than the Western one. Some of the knots displayed a rapid change of brightness during the 2004-2011 period. Over a longer timescale, a progressive circularization and homogenization of the nebula is taking place; (6) a kinematic distance of 400+-30 pc is determined. These results raise some problems to the previous interpretations of the evolution of GK Per. In particular, the idea of a strong interaction of the outflow with the surrounding medium in the Southwest quadrant is not supported by our data.Comment: Accepted for publication in The Astrophysical Journal (19 pages, 17 figures). Higher resolution version of this article (2.5 MB) is available at http://www.aai.ee/~sinope/ApJ89291_liimets.pd

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer

BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC). METHODS: Herein we have overexpressed LKB1 in human hepatoma cells and by using histidine pull-down assay we have investigated the role of the hypoxia-related post-translational modification of Small Ubiquitin-related Modifier (SUMO)ylation in the regulation of LKB1 oncogenic role. Molecular modelling between LKB1 and its interactors, involved in regulation of LKB1 nucleocytoplasmic shuttling and LKB1 activity, was performed. Finally, high affinity SUMO binding entities-based technology were used to validate our findings in a pre-clinical mouse model and in clinical HCC. FINDINGS: We found that in human hepatoma cells under hypoxic stress, LKB1 overexpression increases cell viability and aggressiveness in association with changes in LKB1 cellular localization. Moreover, by using site-directed mutagenesis, we have shown that LKB1 is SUMOylated by SUMO-2 at Lys178 hampering LKB1 nucleocytoplasmic shuttling and fueling hepatoma cell growth. Molecular modelling of SUMO modified LKB1 further confirmed steric impedance between SUMOylated LKB1 and the STe20-Related ADaptor cofactor (STRADα), involved in LKB1 export from the nucleus. Finally, we provide evidence that endogenous LKB1 is modified by SUMO in pre-clinical mouse models of HCC and clinical HCC, where LKB1 SUMOylation is higher in fast growing tumors. INTERPRETATION: Overall, SUMO-2 modification of LKB1 at Lys178 mediates LKB1 cellular localization and its oncogenic role in liver cancer. FUND: This work was supported by grants from NIH (US Department of Health and Human services)-R01AR001576-11A1 (J.M.M and M.L.M-C.), Gobierno Vasco-Departamento de Salud 2013111114 (to M.L.M.-C), ELKARTEK 2016, Departamento de Industria del Gobierno Vasco (to M.L.M.-C), MINECO: SAF2017-87301-R and SAF2014-52097-R integrado en el Plan Estatal de Investigación Cientifica y Técnica y Innovación 2013-2016 cofinanciado con Fondos FEDER (to M.L.M.-C and J.M.M., respectively), BFU2015-71017/BMC MINECO/FEDER, EU (to A.D.Q. and I.D.M.), BIOEF (Basque Foundation for Innovation and Health Research): EITB Maratoia BIO15/CA/014; Instituto de Salud Carlos III:PIE14/00031, integrado en el Plan Estatal de Investigación Cientifica y Técnica y Innovacion 2013-2016 cofinanciado con Fondos FEDER (to M.L.M.-C and J.M.M), Asociación Española contra el Cáncer (T.C.D, P·F-T and M.L.M-C), Daniel Alagille award from EASL (to T.C.D), Fundación Científica de la Asociación Española Contra el Cancer (AECC Scientific Foundation) Rare Tumor Calls 2017 (to M.L.M and M.A), La Caixa Foundation Program (to M.L.M), Programma di Ricerca Regione-Università 2007-2009 and 2011-2012, Regione Emilia-Romagna (to E.V.), Ramón Areces Foundation and the Andalusian Government (BIO-198) (A.D.Q. and I.D.M.), ayudas para apoyar grupos de investigación del sistema Universitario Vasco IT971-16 (P.A.), MINECO:SAF2015-64352-R (P.A.), Institut National du Cancer, FRANCE, INCa grant PLBIO16-251 (M.S.R.), MINECO - BFU2016-76872-R to (E.B.). Work produced with the support of a 2017 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation (M.V-R). Finally, Ciberehd_ISCIII_MINECO is funded by the Instituto de Salud Carlos III. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644). Funding sources had no involvement in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication

Una aproximación práctica para el diseño de un proceso de reciclado de polímeros mediante disolución

La cantidad de residuos plásticos producidos en los últimos años se ha visto incrementada debido a la variedad de usos y las buenas propiedades que estos presentan. Por este motivo, es necesario ofrecer soluciones que permitan un reciclaje adecuado a cada tipo de residuo, siguiendo con las normativas vigentes. Entre las alternativas desarrolladas se encuentran el reciclado mecánico, químico y la incineración, sin embargo, estos metodos cuentan con determinados inconvenientes que dificultan su aplicación. Para solventar estos, se propone el tratamiento de los residuos mediante disolución, lo que implica la seleccion adecuada del mejor disolvente, con el objetivo de tratar la máxima cantidad de plástico posible. Esta selección se desarrolla siguiendo una serie de modelos teóricos que permiten el cálculo del parametro de solubilidad (d), y su interpretación a traves de distintos metodos gráficos que permiten seleccionar de manera sencilla los disolventes más adecuados. Por último, tambíen se muestran estrategias de cálculo para conocer las condiciones de operación que vienen definidas por una concentración y temperatura críticas, que limitan la región en la que la disolución permanece estable, y por tanto, es posible realizar el proceso de reciclado

Study of the kinetic parameters of thermal and oxidative degradation of various residual materials

The thermal decomposition of three biomass residues was studied in this work: cork powder, paper sludge and sewage sludge. Firstly, characterization of the materials was carried out by elemental and proximate analysis and FT-IR spectroscopy. Experiments were carried out in a thermobalance to obtain thermogravimetric curves (TG) and differential thermogravimetric curves (DTG). Two different types of atmosphere were investigated: pyrolysis (100% N2) and combustion (80% N2 20% O2). The effect of the heating rate (5 K min−1, 10 K min−1 and 20 K min−1) was also investigated. Moreover, important combustion parameters were calculated, namely ignition and burnout temperatures and calorific value. A model was proposed for each of the materials and atmospheres in order to calculate the kinetic parameters. The proposed model fitted adequately to the obtained experimental data in all cases, giving and R2 higher than 0.995 and 0.9858 in TG and DTG curves respectively.We gratefully acknowledge the technical and human support provided by CICT of Universidad de Jaén and University of Granada. This research was conducted as part of the SmartMats (MAT2015-70034-R) Project, “Smart materials for sustainable construction”, funded by the Spanish Ministry of Economy and Competitiveness and FEDER. (MINECO-FEDER). The authors gratefully acknowledge this support. The author Irene Iáñez-Rodríguez acknowledges the financial support provided by the Ministry of Education (Spain) through Research Grant FPU16/00223

A Multi-signal Variant for the GPU-based Parallelization of Growing Self-Organizing Networks

Among the many possible approaches for the parallelization of self-organizing networks, and in particular of growing self-organizing networks, perhaps the most common one is producing an optimized, parallel implementation of the standard sequential algorithms reported in the literature. In this paper we explore an alternative approach, based on a new algorithm variant specifically designed to match the features of the large-scale, fine-grained parallelism of GPUs, in which multiple input signals are processed at once. Comparative tests have been performed, using both parallel and sequential implementations of the new algorithm variant, in particular for a growing self-organizing network that reconstructs surfaces from point clouds. The experimental results show that this approach allows harnessing in a more effective way the intrinsic parallelism that the self-organizing networks algorithms seem intuitively to suggest, obtaining better performances even with networks of smaller size.Comment: 17 page