The Fougueux (1785-1805): prototype of an 18th–19th century French construction method

The 74-gun French ship Fougueux (1785-1805) belonged to the Spanish-French fleet that faced the British in the Battle of Trafalgar on 21 October 1805. This warship was lost off the coast of Sancti Petri after the battle. About two centuries later, an array of iron cannons and wooden remains were studied at this site by the Underwater Archaeology Centre of Andalusia. This paper presents the results of the analysis of the ship’s construction method, whose particularities place it within the tradition of French naval construction between the late 18th century and early 19th century.Le navire français de 74 canons Le Fougueux (1785-1805) appartenait à la flotte franco-espagnole qui affronta les Britanniques lors de la bataille de Trafalgar le 21 octobre 1805. Ce navire de guerre fut perdu au large de Sancti Petri après la bataille. Environ deux siècles plus tard, un ensemble de canons de fer et de vestiges en bois ont été étudiés sur ce site par le Centre d’archéologie sousmarine d’Andalousie. Cet article présente les résultats de l’analyse des méthodes de construction du navire, que ses particularités placent dans la tradition de la construction navale française entre la fin du xviiie et le début du xixe siècle.Fil: Rodríguez Mariscal, Nuria E.. Centro de Arqueología Subacuática de Andalucía; EspañaFil: Ciarlo, Nicolás Carlos. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Arqueología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alzaga García, Milagros. Centro de Arqueología Subacuática de Andalucía; EspañaFil: Rieth, Eric. Servicio de Patrimonio Histórico-artístico y Museo; EspañaFil: Izaguirre Lacoste, Manuel. Universite de Paris. Museum National D´historie Naturelle. Centre National de la Recherche Scientifique; Franci

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

El Fougueux, anaàlisis del sistema constructivo de un navío de línea de la armada imperial de Napoléon Bonaparte

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