Current approaches to the treatment of frequently recurrent urticaria.

The article presents summarized materials on etiology, pathogenesis, classification, clinical manifestations and treatment of chronic urticuria, The management of patients with this pathology at Dniprovsky Allergological Center was analyzed. For assessment of quality of life SKINDEX-29 questionnaire was used. The questionnaire includes three sections: symptoms, emotions and functions. Physical symptoms include six points: tenderness, heartburn or tingling, itching unpleasant sensations when cotacting with water, skin irritation, sensitivity. The emotional sphere is characterized by such ten points as: concern about the condition of the skin; deppression; feeling of shame; concern that scars can remain after skin disease; feelings about worsening of the skin; anxious mood; embarrassment, feeling of humiliation; skin irritation; rejection of oneself. “Features” section has twelve items: sleep quality; work and hobbies; social activity; sex life; solitude; fatigue; unwillingness to leave home; limiting intimacy with others; complexity in carrying out daily activities; difficulty in expressing feelings; obstruction to create relationships with others; limiting close communication with relatives. Gastrointestinal system was also examined: fibrogastroduodenoscopy with determination of Helicobacter Pylori, ultrasound diagnosis of abdominal organs, the intensity of clinical symptoms was determined on a UAS7 scale. Fifteen patients (including eight women and seven men) were successfully treated with omalizumab. The mean age was 39.1 ± 3.6 years. The average duration of the disease in patients was 5.1 ± 0.9 years. The intensity of symptoms was determined before treatment after the first and second injection of Omalizumab. After the first injection, there was a positive trend. The clinical effect occurred in seventy-two hours. Statistical processing of the study results was performed using Statistica v.6.1® software. (StatSoft, USA). The inclusion of omalizumab is an effective treatment for chronic urticaria in the absence of an effect from antihistamines

Efficacy of combination of antihistaminic agents and blocker of leukotriene receptors in the treatment of pollinosis exacerbation with bronchial asthma attacks.

We have been observing 60 pollinosis patients at the age of 19 to 64 years with clinical manifestations of rhinitis, conjunctivitis, bronchial asthma. The study was conducted in the design of parallel groups. All patients were divided into 2 clinical groups (main and control), depending on the treatment regimen. The main group included 40 patients who received a combined drug Glencet Advance 1 tab. in the evening for 1 month. 20 patients included in the control group received symptomatic local therapy (eye drops, IGCC), β2-short-acting agonists. Results: integral assessment of symptoms in the main group before treatment was 11.50±0.13 and significantly decreased after treatment to 0.68±0.14 (p<0.001). In the control group differences were much less expressed from 11.15±0.22 before treatment to 3.05±0.29 (p<0.001) after treatment. FEV1 (%) in the main group has been improving more intensively (from 55.5±1.14 to 90.7±1.31 (p<0.01). PEF has been improving from 187.5±4.34 l/sec to 406.3±10.73 (p<0.001). In the control group these changes are less expressed for FEV1 (%) from 56.2±1.72 to 78.5±2.18 (p<0.001). PEF l/sec – (from 195.0±6.75 to 320.0±12.50 (p<0.01)). The histamine level decrease (ng/ml) in the main group was reliable – from 4.29±0.52 to 1.40±0.3 (p<0.5). In the control group – from 3.00±0.33 to 2.82±0.31 (there is no veracious data). Change of the total IgE level in serum: veracious decrease from 487.2 to 367.8 in the main group, no veracious decrease in the control group. Conclusions: the use of combined therapy with antihistamines and antileukotriene drugs in patients with pollinosis gives a good clinical effect, which is confirmed by a veracious decrease of histamine and total IgE levels in blood serum, as well as by veracious improvement in FEV1 and PEF

Current approaches to the treatment of frequently recurrent urticaria.

The article presents summarized materials on etiology, pathogenesis, classification, clinical manifestations and treatment of chronic urticuria, The management of patients with this pathology at Dniprovsky Allergological Center was analyzed. For assessment of quality of life SKINDEX-29 questionnaire was used. The questionnaire includes three sections: symptoms, emotions and functions. Physical symptoms include six points: tenderness, heartburn or tingling, itching unpleasant sensations when cotacting with water, skin irritation, sensitivity. The emotional sphere is characterized by such ten points as: concern about the condition of the skin; deppression; feeling of shame; concern that scars can remain after skin disease; feelings about worsening of the skin; anxious mood; embarrassment, feeling of humiliation; skin irritation; rejection of oneself. “Features” section has twelve items: sleep quality; work and hobbies; social activity; sex life; solitude; fatigue; unwillingness to leave home; limiting intimacy with others; complexity in carrying out daily activities; difficulty in expressing feelings; obstruction to create relationships with others; limiting close communication with relatives. Gastrointestinal system was also examined: fibrogastroduodenoscopy with determination of Helicobacter Pylori, ultrasound diagnosis of abdominal organs, the intensity of clinical symptoms was determined on a UAS7 scale. Fifteen patients (including eight women and seven men) were successfully treated with omalizumab. The mean age was 39.1 ± 3.6 years. The average duration of the disease in patients was 5.1 ± 0.9 years. The intensity of symptoms was determined before treatment after the first and second injection of Omalizumab. After the first injection, there was a positive trend. The clinical effect occurred in seventy-two hours. Statistical processing of the study results was performed using Statistica v.6.1® software. (StatSoft, USA). The inclusion of omalizumab is an effective treatment for chronic urticaria in the absence of an effect from antihistamines

Current approaches to the treatment of frequently recurrent urticaria.

The article presents summarized materials on etiology, pathogenesis, classification, clinical manifestations and treatment of chronic urticuria, The management of patients with this pathology at Dniprovsky Allergological Center was analyzed. For assessment of quality of life SKINDEX-29 questionnaire was used. The questionnaire includes three sections: symptoms, emotions and functions. Physical symptoms include six points: tenderness, heartburn or tingling, itching unpleasant sensations when cotacting with water, skin irritation, sensitivity. The emotional sphere is characterized by such ten points as: concern about the condition of the skin; deppression; feeling of shame; concern that scars can remain after skin disease; feelings about worsening of the skin; anxious mood; embarrassment, feeling of humiliation; skin irritation; rejection of oneself. “Features” section has twelve items: sleep quality; work and hobbies; social activity; sex life; solitude; fatigue; unwillingness to leave home; limiting intimacy with others; complexity in carrying out daily activities; difficulty in expressing feelings; obstruction to create relationships with others; limiting close communication with relatives. Gastrointestinal system was also examined: fibrogastroduodenoscopy with determination of Helicobacter Pylori, ultrasound diagnosis of abdominal organs, the intensity of clinical symptoms was determined on a UAS7 scale. Fifteen patients (including eight women and seven men) were successfully treated with omalizumab. The mean age was 39.1 ± 3.6 years. The average duration of the disease in patients was 5.1 ± 0.9 years. The intensity of symptoms was determined before treatment after the first and second injection of Omalizumab. After the first injection, there was a positive trend. The clinical effect occurred in seventy-two hours. Statistical processing of the study results was performed using Statistica v.6.1® software. (StatSoft, USA). The inclusion of omalizumab is an effective treatment for chronic urticaria in the absence of an effect from antihistamines

On strong causal binomial approximation for stochastic processes

This paper considers binomial approximation of continuous time stochastic processes. It is shown that, under some mild integrability conditions, a process can be approximated in mean square sense and in other strong metrics by binomial processes, i.e., by processes with fixed size binary increments at sampling points. Moreover, this approximation can be causal, i.e., at every time it requires only past historical values of the underlying process. In addition, possibility of approximation of solutions of stochastic differential equations by solutions of ordinary equations with binary noise is established. Some consequences for the financial modelling and options pricing models are discussed

On limit periodicity of discrete time stochastic processes

We consider a discrete time dynamic system described by a difference equation with periodic coefficients and with additive stochastic noise. We investigate the possibility of the periodicity of the solution. In particular, we established sufficient conditions for convergence of the solution in mean square or almost surely to some stochastic periodic process

Sensitivity of <i>Streptococcus</i> <i>viridans</i> to antibacterial agents in HIV-positive patients coupled to respiratory diseases

The streptococcus group consists of multiple species of globular Gram-positive facultative anaerobic bacteria, the classification of which is based on assessing their capacity to erythrocyte hemolysis. The viridans group streptococci produce a green coloration being a part of normal microflora in the oral cavity. However, in case of developing immunodeficiency states, oncology, and neutropenia, this pathogen can cause diseases such as bacteremia, sepsis, endocarditis, as well as pneumonia in some cases. Respiratory diseases commonly require medical assistance in HIV-infected patient cohort. The role of commensal S. viridans in development of bacterial diseases in HIV-infected patients remains poorly examined. A potential association between S. viridans and other bacterial communities, including pathogenic microorganisms is obscure. In addition, it might be worth evaluating sensitivity of S. viridans to antibacterial agents in regions with high HIV infection incidence. The aim of the study was to evaluate sensitivity to antibiotics in sputum viridans group streptococci collected from HIV-infected patients with symptomatic pneumonia. Materials and methods. The data on sputum microbiological study conducted within the 01.01.2012—01.01.2019 interval were collected from all HIV-infected patients with suspected pneumonia (n = 684) and analyzed at the Infectious Clinical Hospital No. 1 named after D.M. Dalmatov, among which S. viridans was detected in 193 patients (28.2%). Bacteriological examination of patient samples was conducted to isolate pure bacterial culture by using standard methods. Next, S. viridans was assessed for sensitivity to antibacterial agents (n = 78) according to the 2018 clinical recommendations. Initially, antibiotic resistance was assessed by disk-diffusion method as a routine approach broadly used in clinical laboratory. After that, the minimal inhibitory concentration was measured by using AutoScan 4 Microscan analyzer (bacteriological semi-automatic analyzer, Beckman Coulter, USA) to identify and determine antibacterial sensitivity. Results. A disk-diffusion method allowed to find in sputum samples streptococci resistant to penicillin in 28.2% cases, ampicillin — in 42.3% and cefazolin — in 43.6%. While assessing the minimal inhibitory concentration for antibacterial agents, similar data were obtained. Good sensitivity was found for cefotaxime, ceftriaxone, cefepime, fluoroquinolones and vancomycin

Розробка системи кондиціювання з рекуперацією видаляємого повітря з метою забезпечення оптимальних параметрів мікроклімату в приміщеннях будівель

Abstract. Ensuring microclimate parameters is possible with the help of air conditioning systems, which are large consumers of traditional energy sources (coal, oil, gas). Combustion of these forms of energy leads to environmental pollution. Atmospheric air is one of the main natural environment vital elements. Currently, in many countries, air pollution has exceeded the allowed level of adaptation of living organisms, including the human body. In most developed countries have already developed a program to protect the atmosphere, based on long-term forecasts of air pollution, as well as on the national concept of the protection of the atmosphere. Much attention is paid to this issue, and Ukraine. Reducing the environmental impact on the environment is possible through the development of technologies environmentally friendly life-support systems that use renewable energy sources. The quality of maintenance of microclimate parameters should not deteriorate as it would lead to reduced efficiency and human health. Therefore, today is the actual development of efficient life-support systems, to ensure reduction of emissions into the environment. Purpose. The aim of this work is to develop a conditioning system with heat recovery exhaust air to ensure optimum microclimate in the buildings. Findings. Let us consider each of the building life-support system alone, namely, the heating, ventilation and air conditioning, it was found that the provision of optimal parameters of the microclimate in the buildings is not possible without the work of these complex systems. The heating system is able to maintain a given level of internal temperature of the air that meets the conditions of thermal comfort and process requirements. The ventilation system is able to ensure the maintenance of the required level of a wide set of air parameters: temperature (in all cases), mobility (speed), relative humidity (not in all cases), dust, concentration of harmful substances. The air conditioning system, as opposed to the ventilation, not only provides the necessary air change in the room, but also automatically maintains the set conditions it is not dependent on external climatic factors and the internal mode in the room. Practical value. The air conditioning system with heat recovery exhaust air will improve the microclimate in the buildings, as well as improve productivity of man.Аннотация. Обеспечение параметров микроклимата возможно с помощью систем кондиционирования воздуха, которые являются большими потребителями традиционных видов энергии (уголь, мазут, газ). Сжигание этих видов энергии приводит к загрязнению окружающей среды. Атмосферный воздух является одним из основных жизненно важных элементов окружающей природной среды. В настоящее время во многих странах загрязнение воздушного бассейна уже превысило возможный уровень адаптации живых организмов, в том числе, организма человека. В наиболее развитых странах уже разработана программа защиты атмосферы, базирующаяся на долгосрочных прогнозах загрязнения воздуха, а так же на общегосударственной концепции защиты атмосферы. Большое внимание этой проблеме уделяется и на Украине. Снижение экологической нагрузки на окружающую среду возможно путем разработки технологий экологически чистых систем жизнеобеспечения, в которых используются возобновляемые источники энергии. При этом качество поддержания параметров микроклимата не должно ухудшаться, так как это приведет к снижению работоспособности и самочувствия человека. Следовательно, на сегодняшний день актуальным является разработка эффективных систем жизнеобеспечения, обеспечивающих снижение выбросов в окружающую среду. Цель. Целью данной работы является разработка системы кондиционирования с рекуперацией удаляемого воздуха с целью обеспечения оптимальных параметров микроклимата в помещениях зданий. Результаты. Рассмотрев каждую систему жизнеобеспечения здания в отдельности, а именно системы отопления, вентиляции и кондиционирования воздуха, установлено, что обеспечение оптимальных параметров микроклимата в помещениях зданий не возможно без комплексной работы этих систем. Система отопления способна поддерживать на заданном уровне температуру внутреннего воздуха, отвечающую условиям теплового комфорта и требованиям технологического процесса. Система вентиляции способна обеспечить поддержание на требуемом уровне широкого набора параметров воздуха: температура (не во всех случаях), подвижность (скорость), относительная влажность (не во всех случаях), запыленность, концентрация вредных веществ. Система кондиционирования воздуха, в отличие от приточно-вытяжной вентиляции, обеспечивает не только необходимую смену воздуха в помещении, но и автоматически поддерживает заданные условия в нем не зависимо от внешних климатических факторов и внутреннего режима работы в помещении. Практическая значимость. Система кондиционирования с рекуперацией удаляемого воздуха позволит улучшить микроклимат в помещениях зданий, а также повысить производительность труда человека.Анотація. Забезпечення параметрів мікроклімату можливо за допомогою систем кондиціювання повітря, які є великими споживачами традиційних видів енергії (вугілля, мазут, газ). Спалювання цих видів енергії призводить до забруднення навколишнього середовища. Атмосферне повітря є одним з основних життєво важливих елементів навколишнього природного середовища. В даний час в багатьох країнах забруднення повітряного басейну вже перевищило можливий рівень адаптації живих організмів, в тому числі, організму людини. У найбільш розвинених країнах вже розроблена програма захисту атмосфери, що базується на довгострокових прогнозах забруднення повітря, а так само на загальнодержавній концепції захисту атмосфери. Велика увага цій проблемі приділяється і на Україні. Зниження екологічного навантаження на навколишнє середовище можливо шляхом розробки технологій екологічно чистих систем життєзабезпечення, в яких використовуються поновлювані джерела енергії. При цьому якість підтримки параметрів мікроклімату не повинно погіршуватися, так як це призведе до зниження працездатності та самопочуття людини. Отже, на сьогоднішній день актуальним є розробка ефективних систем життєзабезпечення, що забезпечують зниження викидів в навколишнє середовище. Мета. Метою даної роботи є розробка системи кондиціювання з рекуперацією видаляємого повітря з метою забезпечення оптимальних параметрів мікроклімату в приміщеннях будівель. Результати. Розглянувши кожну систему життєзабезпечення будівлі окремо, а саме системи опалення, вентиляції та кондиціонування повітря, встановлено, що забезпечення оптимальних параметрів мікроклімату в приміщеннях будівель неможливо без комплексної роботи цих систем. Система опалення здатна підтримувати на заданому рівні температуру внутрішнього повітря, що відповідає умовам теплового комфорту і вимогам технологічного процесу. Система вентиляції здатна забезпечити підтримку на необхідному рівні широкого набору параметрів повітря: температура (не у всіх випадках), рухливість (швидкість), відносна вологість (не у всіх випадках), запиленість, концентрація шкідливих речовин. Система кондиціювання повітря, на відміну від припливно-витяжної вентиляції, забезпечує не тільки необхідну зміну повітря в приміщенні, але і автоматично підтримує задані умови в ньому не залежно від зовнішніх кліматичних факторів і внутрішнього режиму роботи в приміщенні. Практична значимість. Система кондиціювання з рекуперацією видаляємого повітря дозволить поліпшити мікроклімат в приміщеннях будівель, а також підвищити продуктивність праці людини

Current Approaches to the Treatment of Frequently Recurrent Urticaria.

The article presents summarized materials on etiology, pathogenesis, classification, clinical manifestations and treatment of chronic urticuria, The management of patients with this pathology at Dniprovsky Allergological Center was analyzed. For assessment of quality of life SKINDEX-29 questionnaire was used. The questionnaire includes three sections: symptoms, emotions and functions. Physical symptoms include six points: tenderness, heartburn or tingling, itching unpleasant sensations when cotacting with water, skin irritation, sensitivity. The emotional sphere is characterized by such ten points as: concern about the condition of the skin; deppression; feeling of shame; concern that scars can remain after skin disease; feelings about worsening of the skin; anxious mood; embarrassment, feeling of humiliation; skin irritation; rejection of oneself. “Features” section has twelve items: sleep quality; work and hobbies; social activity; sex life; solitude; fatigue; unwillingness to leave home; limiting intimacy with others; complexity in carrying out daily activities; difficulty in expressing feelings; obstruction to create relationships with others; limiting close communication with relatives. Gastrointestinal system was also examined: fibrogastroduodenoscopy with determination of Helicobacter Pylori, ultrasound diagnosis of abdominal organs, the intensity of clinical symptoms was determined on a UAS7 scale. Fifteen patients (including eight women and seven men) were successfully treated with omalizumab. The mean age was 39.1 ± 3.6 years. The average duration of the disease in patients was 5.1 ± 0.9 years. The intensity of symptoms was determined before treatment after the first and second injection of Omalizumab. After the first injection, there was a positive trend. The clinical effect occurred in seventy-two hours. Statistical processing of the study results was performed using Statistica v.6.1® software. (StatSoft, USA). The inclusion of omalizumab is an effective treatment for chronic urticaria in the absence of an effect from antihistamines