Extraction and Characterization of Phenolic Compounds from Rose Hip (Rosa canina L.) Using Liquid Chromatography Coupled with Electrospray Ionization - Mass Spectrometry

Wild berry are a rich of natural compounds which provide them high antioxidant potential. The compounds which provide them these proprieties are known to be vitamins, flavonoids, anthocyanins and phenolic acids. The aim of this study was to extract and characterize bioactive compounds from rose hip (Rosa canina L.) currently found in Romania. A qualitative high-performance liquid chromatography coupled with electrospray ionization mass spectrometric (ESI-MS) detection in positive ion mode has been used to identify phenolic compounds from rose hip crude extract. The chromatograms revealed the presence of a large number of compounds (19), identified and grouped as phenolic acids and flavones/ols, flavan-3-ols and also anthocyanins. Based on obtained results these berries can be highly recommended as part of our diet. Also this finding represents a contribution to the chemical characterization of phenolic profile of rose hip

`Similar' coordinate systems and the Roche geometry. Application

A new equivalence relation, named relation of 'similarity' is defined and applied in the restricted three-body problem. Using this relation, a new class of trajectories (named 'similar' trajectories) are obtained; they have the theoretical role to give us new details in the restricted three-body problem. The 'similar' coordinate systems allow us in addition to obtain a unitary and an elegant demonstration of some analytical relations in the Roche geometry. As an example, some analytical relations published in Astrophysical Journal by Seidov in 2004 are demonstrated.Comment: 9 pages (preprint format), 9 figures, published in Astrophysics and Space Scienc

Особенности диагностики лимфом шейной области у детей

Thisarticle discusses various aspects of pediatric lymphadenopathy, focusing on Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). It outlines common etiologies, diagnostic techniques, and key characteristics of differ- ent lymphoma subtypes. HL is classified into classical HL (CHL) and nodular lymphocytic predominant HL (NLPHL), while NHL includes Burkitt lymphoma (BL), lymphoblastic lymphoma (LBL), diffuse large B-cell lymphoma (DLBCL), and anaplastic large cell lymphoma (ALCL). The text emphasizes the importance of accurate diagnosis through various tests, including imaging modalities such as positron emission tomography (PET) and computed tomography (CT). It also discusses the potential use of ctDNA as a prognostic marker and highlights genetic alterations contributing to lymphoma development. The relevance of these findings for pediatric patients and their impact on treatment strategies is emphasized throughout the text.Acest articol discută diferite aspecte ale limfadenopatiei pediatrice, concentrându-se pe limfomul Hodgkin (HL) și limfomul non-Hodgkin (NHL). Acesta prezintă etiologiile comune, tehnicile de diagnosticare și caracteristicile cheie ale diferitelor subtipuri de limfom. HL este clasificat în HL clasic (CHL) și HL predominant limfocitar nodular (NLPHL), în timp ce NHL include limfomul Burkitt (BL), limfomul limfoblastic (LBL), limfomul difuz cu celule B mari (DLB- CL) și limfomul anaplazic cu celule mari (ALCL). Textul subliniază importanța diagnosticului precis prin diverse teste, inclusiv modalități imagistice, cum ar fi tomografia cu emisie de pozitroni (PET) și tomografia computerizată (CT). De asemenea, se discută despre utilizarea potențială a ctDNA ca marker de prognostic și evidențiază modificările genetice care contribuie la dezvoltarea limfomului. Relevanța acestor constatări pentru pacienții pediatrici și impactul lor asupra strategiilor de tratament este subliniată pe tot parcursul textului.В этой статье обсуждаются различные аспекты детской лимфаденопатии, уделяя особое внимание лимфоме Ходжкина (ЛХ) и неходжкинской лимфоме (НХЛ). В нем представлены общие этиологии, методы диагностики и ключевые особенности различных подтипов лимфом. ЛХ подразделяется на классическую ЛХ (ХЛ) и узловую лимфоцитарную ЛХ (НЛФЛ), в то время как НХЛ включает лимфому Беркитта (БЛ), лимфобластную лимфому (ЛБЛ), диффузную крупноклеточную В-клеточную лимфому (ДКБКЛ) и анапластическую крупноклеточную лимфому (АККЛ)). В тексте подчеркивается важность точной диагностики с помощью различных тестов, включая такие методы визуализации, как позитронно-эмиссионная томография (ПЭТ) и компьютерная томография (КТ). В нем также обсуждается потенциальное использование ктДНК в качестве прогностического маркера и подчеркиваются генетические изменения, которые способствуют развитию лимфомы. Актуальность этих результатов для педиатрических пациентов и их влияние на стратегии лечения подчеркивается на протяжении всего текста

PLANTELE TRANSGENICE – AVANTAJE ÎN PRIVINŢA CULTIVĂRII LOR ŞI RISCURI LEGATE DE SIGURANŢA ALIMENTELOR

During the last decades the genetic modifi ed organisms (GMO) have started to “conquer”, little by little our lives. The most widely used are the trangenic plants, because they have bigger productions and they are resistant to different pests. In the beginning, the spread of the transgenic plants was controlled, but today many countries cultivate genetic modifi ed plants without any control. Among these countries Romania is ahead, starting the cultivation of the transgenic plants in 1999, very soon after their obtaining. This paper outline the effect of the food consumption obtained from this plants which may determine different effects on human body. Also, because the genetic modifi ed plants have bigger productions than the normal ones and they are more resistant, the farmers are not encouraged to declare that they are using genetic modifi ed seeds. So, in that way, the consumer does not know what kind of food he consumes.În timpul ultimelor decenii organismele modifi cate genetic (OMG) au început să ne “cucerească” vieţile. Cle mai răspândite sunt plantele transgenice, pentru că ele au produtii mai crescute şi sunt rezistente la diferite boli. La început răspândirea plantelor transgenice era controlată dar în prezent multe ţări cultivă plante transgenice fără nici un control. Printre aceste ţări România ocupă un loc de frunte, începând cultivarea plantelro transgenice încă din 1999, imediat după obţinerea lor. Această lucrare subliniază efectele consumării alimentelor obţinute din aceste plante care pot avea efecte diferite asupra corpului uman. De asemenea, deoarece plantele modifi cate genetic au producţii mai crescute comparativ cu plantele normale si, de asemenea sunt mai rezistente, fermierii nu sunt încurajaţi să declare că folosesc seminţe provenite de la plante transgenice. Astfel, în acest fel consumatorul nu mai ştie ce fel de aliment consumă

Angina pectoris ”de novo", case report

Disciplina Cardiologie, Clinica Medicală nr.3, Departamentul Medicină Internă, USMF „Nicolae Testemiţanu”Ischemic heart disease is the most common cardiac pathology. Angina pectoris (AP) "de novo" is a form of unstable AP, a clinical expression of acute coronary syndrome (ACS), which is characterized by constrictive retrosternal pain at rest or on exercise, occurring less than 30 days. AP "de novo" may evolve, depending on the structure of atherosclerotic plaque in two directions: stable AP or acute myocardial infarction (AMI). We present the clinical case of a 61 years old man with no history of ischemic heart disease, which developed an acute coronary syndrome without ST segment elevation as the result of angina pectoris "de novo". Cardiopatia ischemică este cea mai frecventă patologie cardiacă. Angina pectorală (AP) de „novo” reprezintă o formă a AP instabile, expresie clinică a sindromului coronarian acut (SCA), care se caracterizează prin dureri retrosternale constrictive în repaus sau la efort, cu debutul până la 30 de zile. AP de „novo” poate evolua, în dependenţă de structura placii aterosclerotice, în 2 direcţii: AP stabilă sau infarct miocardic acut (IMA). Prezentăm cazuclinic a unui bărbat de 61 ani, fără antecedente de cardiopatie ischemică, care a dezvoltat un sindrom coronarian acut fără supradenivelare de segment ST, ca urmare a anginei pectorale ”de novo”

Tachyarrhythmias in pregnancy, case report

Disciplina Cardiologie, Clinica Medicală nr.3, Departamentul Medicină Internă, Catedra Obstetrică şi Ginecologie FCMF USMF „Nicolae Testemiţanu”,IMSP Institutul Mamei şi CopiluluiSinus tachycardia (TS) is a heart rhythm disorder characterized by the acceleration of sinusal rhythm, 100 beats / minute. TS is a physiological response to effort, stress, pregnancy, and in diseases: hyperthyroidism, myocardial infarction, pulmonary artery thromboembolism, infections, anemia, bleeding, neuroses, etc.. During pregnancy the heart rate increases by 25%, thus TS, especially in the third trimester, reaches an incidence of 50% (non-sustained arrhythmia) and sustained tachycardias have a lower frequency – 2 - 3 to 1000 pregnant. We present the clinical case of a pregnant of 28 years with sinus tachycardia clinically and electrocardiographicaly manifested, with adequate response to treatment. Tahicardia sinusală (TS) este o tulburare de ritm cardiac caracterizată prin accelerarea ritmului sinusal, peste 100 bătăi/minut. TS se declanşează ca răspuns fiziologic la efort, stres, sarcină, dar şi în patologii: hipertiroidism, infarct miocardic, trombembolia arterei pulmonare, infecţii, anemie, hemoragii, nevroze etc. La gravide ritmul cardiac creşte cu peste 25%, astfel, TS, în special în al treilea trimestru, atinge o incidenţă de peste 50% (aritmie non-durabilă), iar tahicardia susţinută are o frecvenţă mai joasă – 2 - 3 la 1000 însărcinate. Prezentăm cazul clinic al parturientei de 28 ani cu TS manifestată clinic şi electrocardiografic, cu răspuns adecvat la tratament administrat

A Cryogenic Silicon Interferometer for Gravitational-wave Detection

The detection of gravitational waves from compact binary mergers by LIGO has opened the era of gravitational wave astronomy, revealing a previously hidden side of the cosmos. To maximize the reach of the existing LIGO observatory facilities, we have designed a new instrument able to detect gravitational waves at distances 5 times further away than possible with Advanced LIGO, or at greater than 100 times the event rate. Observations with this new instrument will make possible dramatic steps toward understanding the physics of the nearby Universe, as well as observing the Universe out to cosmological distances by the detection of binary black hole coalescences. This article presents the instrument design and a quantitative analysis of the anticipated noise floor

A Cryogenic Silicon Interferometer for Gravitational-wave Detection

The detection of gravitational waves from compact binary mergers by LIGO has opened the era of gravitational wave astronomy, revealing a previously hidden side of the cosmos. To maximize the reach of the existing LIGO observatory facilities, we have designed a new instrument that will have 5 times the range of Advanced LIGO, or greater than 100 times the event rate. Observations with this new instrument will make possible dramatic steps toward understanding the physics of the nearby universe, as well as observing the universe out to cosmological distances by the detection of binary black hole coalescences. This article presents the instrument design and a quantitative analysis of the anticipated noise floor

A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings

BackgroundA composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data.MethodsWe assembled a data set of 14-day CGM tracings from 225 insulin-treated adults with diabetes. Using a balanced incomplete block design, 330 clinicians who were highly experienced with CGM analysis and interpretation ranked the CGM tracings from best to worst quality of glycemia. We used principal component analysis and multiple regressions to develop a model to predict the clinician ranking based on seven standard metrics in an Ambulatory Glucose Profile: very low-glucose and low-glucose hypoglycemia; very high-glucose and high-glucose hyperglycemia; time in range; mean glucose; and coefficient of variation.ResultsThe analysis showed that clinician rankings depend on two components, one related to hypoglycemia that gives more weight to very low-glucose than to low-glucose and the other related to hyperglycemia that likewise gives greater weight to very high-glucose than to high-glucose. These two components should be calculated and displayed separately, but they can also be combined into a single Glycemia Risk Index (GRI) that corresponds closely to the clinician rankings of the overall quality of glycemia (r = 0.95). The GRI can be displayed graphically on a GRI Grid with the hypoglycemia component on the horizontal axis and the hyperglycemia component on the vertical axis. Diagonal lines divide the graph into five zones (quintiles) corresponding to the best (0th to 20th percentile) to worst (81st to 100th percentile) overall quality of glycemia. The GRI Grid enables users to track sequential changes within an individual over time and compare groups of individuals.ConclusionThe GRI is a single-number summary of the quality of glycemia. Its hypoglycemia and hyperglycemia components provide actionable scores and a graphical display (the GRI Grid) that can be used by clinicians and researchers to determine the glycemic effects of prescribed and investigational treatments