Water as an economic good: a solution, or a problem ?

Water resource management / Economic aspects / Economic analysis / Irrigated farming / Water rights / Pricing / Privatization / Marginal analysis / Water market / Water policy

IMF and [Na/Fe] abundance ratios from optical and NIR Spectral Features in Early-type Galaxies

We present a joint analysis of the four most prominent sodium-sensitive features (NaD, NaI8190, NaI1.14, and NaI2.21), in the optical and Near-Infrared spectral range, of two nearby, massive (sigma~300km/s), early-type galaxies (named XSG1 and XSG2). Our analysis relies on deep VLT/X-Shooter long-slit spectra, along with newly developed stellar population models, allowing for [Na/Fe] variations, up to 1.2dex, over a wide range of age, total metallicity, and IMF slope. The new models show that the response of the Na-dependent spectral indices to [Na/Fe] is stronger when the IMF is bottom heavier. For the first time, we are able to match all four Na features in the central regions of massive early-type galaxies, finding an overabundance of [Na/Fe], in the range 0.5-0.7dex, and a bottom-heavy IMF. Therefore, individual abundance variations cannot be fully responsible for the trends of gravity-sensitive indices, strengthening the case towards a non-universal IMF. Given current limitations of theoretical atmosphere models, our [Na/Fe] estimates should be taken as upper limits. For XSG1, where line strengths are measured out to 0.8Re, the radial trend of [Na/Fe] is similar to [Mg/Fe] and [C/Fe], being constant out to 0.5Re, and decreasing by 0.2-0.3dex at 0.8Re, without any clear correlation with local metallicity. Such a result seems to be in contrast with the predicted increase of Na nucleosynthetic yields from AGB stars and TypeII SNe. For XSG1, the Na-inferred IMF radial profile is consistent, within the errors, with that derived from TiO features and the Wing-Ford band, presented in a recent paper.Comment: 22 pages, 8 figure, accepted for publication in MNRAS. The new Na-enhanced models will be available soon at http://miles.iac.es

Culture change in a professional sports team: Shaping environmental contexts and regulating power

Although high performing cultures are crucial for the enduring success of professional sport performance teams, theoretical and practical understanding of how they are established and sustained is lacking. To develop knowledge in this area, a case study was undertaken to examine the key mechanisms and processes of a successful culture change programme at English Rugby Union’s Leeds Carnegie. Exploring the change process from a 360 degree perspective, semi-structured interviews were conducted with team management, one specialist coach, six players, and the CEO. Analysed and explained through decentred theory, results revealed that culture change was effectively facilitated by team management: a) subtly and covertly shaping the physical, structural, and psychosocial context in which support staff and players made performance-impacting choices, and b) regulating the ‘to and fro’ of power which characterises professional sport performance teams. Decentred theory is also supported as an effective framework for culture change study

HIGH-LEVEL APPLICATION FRAMEWORK FOR LCLS*

each other easily. Also, many components such as Help, A framework for high level accelerator application Search, Cut, Copy and Paste are seamlessly integrated software is being developed for the Linac Coherent Light through the Eclipse framework. Source (LCLS). The framework is based on plug-in technology developed by an open source project, Eclipse. Many existing functionalities provided by Eclipse are available to high-level applications written within this framework. The framework also contains static data storage configuration and dynamic data connectivity. Because the framework is Eclipse-based, it is highly compatible with any other Eclipse plug-ins. The entire infrastructure of the software framework will be presented. Planned applications and plug-ins based on the framework are also presented

1003. Targeted Site-Specific Integration in Human Cells Using Designed Zinc Finger Nucleases

We have shown previously that human genome editing can be performed at high efficiency using designed zinc finger nucleases (ZFNs). ZFNs can be engineered to generate a double-strand break at a specific chromosomal location both in transformed and primary human cells. These breaks are repaired by the cell's own DNA repair machinery, and when a homologous extrachromosomal donor molecule is provided, a homology-directed repair process leads to highly efficient transfer of single-base-pair changes into the chromosome (Urnov et al. Nature 435: 646). ZFNs can be engineered to target virtually any chromosomal location (Pabo et al., Ann. Rev. Biochem. 70: 313), and function robustly in human hematopoietic stem cells, hence such localized gene modification may potentially be useful in the correction and treatment of certain monogenic diseases. Here we show that ZFNs can also be used for the preciseinsertion of a novel sequence into a pre-determined location in the human genome. Remarkably, this novel sequence can constitute a short patch sequence or several kilobases of one or more transgenes. We have observed ZFN-driven targeted integration into endogenous chromosomal loci in human cells of entire open reading frames and promoter-transcription units at a frequency of 5% in the absence of any selection. We also show the use of this process to disrupt with high efficiency an endogenous chromosomal locus with a selectable marker ORF. Finally, we describe our work on using ZFN-driven integration to insert a therapeutically-relevant transgene into a |[ldquo]|safe-harbor|[rdquo]| locus in the human genome, potentially avoiding the problem of insertional mutagenesis. Hence, the homology-directed repair process invoked by the ZFNs can be used to carry out high-efficiency targeted integration to potentially improve the safety and efficacy of gene therapy

Brief of Corporate Law Professors as Amici Curie in Support of Respondents

The Supreme Court has looked to the rights of corporate shareholders in determining the rights of union members and non-members to control political spending, and vice versa. The Court sometimes assumes that if shareholders disapprove of corporate political expression, they can easily sell their shares or exercise control over corporate spending. This assumption is mistaken. Because of how capital is saved and invested, most individual shareholders cannot obtain full information about corporate political activities, even after the fact, nor can they prevent their savings from being used to speak in ways with which they disagree. Individual shareholders have no “opt out” rights or practical ability to avoid subsidizing corporate political expression with which they disagree. Nor do individuals have the practical option to refrain from putting their savings into equity investments, as doing so would impose damaging economic penalties and ignore conventional financial guidance for individual investors

Ambiguous figures and the content of experience

Representationalism is the position that the phenomenal character of an experience is either identical with, or supervenes on, the content of that experience. Many representationalists hold that the relevant content of experience is nonconceptual. I propose a counterexample to this form of representationalism that arises from the phenomenon of Gestalt switching, which occurs when viewing ambiguous figures. First, I argue that one does not need to appeal to the conceptual content of experience or to judgements to account for Gestalt switching. I then argue that experiences of certain ambiguous figures are problematic because they have different phenomenal characters but that no difference in the nonconceptual content of these experiences can be identified. I consider three solutions to this problem that have been proposed by both philosophers and psychologists and conclude that none can account for all the ambiguous figures that pose the problem. I conclude that the onus is on representationalists to specify the relevant difference in content or to abandon their position

On the effects of the final state interaction in the electro-disintegration of the deuteron at intermediate and high energies

The role of the final state interactions (FSI) in the inclusive quasi-elastic disintegration of the deuteron is investigated treating the two-nucleon final state within the exact continuum solutions of the non-relativistic Schroedinger equation, as well as within the Glauber multiple scattering approach. It is shown that for values of the Bjorken scaling variable $x_{Bj}\simeq 1$ both approaches provide similar results, unless the case $x_{Bj}\gtrsim 1$, where they appreciably disagree. It is demonstrated that present experimental data, which are mostly limited to a region of four-momentum transfer ($Q^2 \lesssim 4 (GeV/c)^2$) where the Center-of-Mass energy of the final state is below the pion threshold production, can be satisfactorily reproduced by the approach based on the exact solution of the Schroedinger equation and not by the Glauber approach. It is also pointed out that the latter, unlike the former, does not satisfy the inelastic Coulomb sum rule, the violation being of the order of about 20%.Comment: 16 LaTeX pages, 10 eps-figures, 1 tabl

Small Noncoding RNA Expression in Cancer

Despite an inability to encode proteins, small noncoding RNAs (sncRNAs) have critical functions in the regulation of gene expression. They have demonstrated roles in cancer development and progression and are frequently dysregulated. Here we review the biogenesis and mechanism of action, expression patterns, and detection methods of two types of sncRNAs frequently described in cancer: miRNAs and piRNAs. Both miRNAs and piRNAs have been observed to play both oncogenic and tumor-suppressive roles, with miRNAs acting to directly regulate the mRNA of key cancer-associated genes, while piRNAs play crucial roles in maintaining the integrity of the epigenetic landscape. Elucidating these important functions of sncRNAs in normal and cancer biology relies on numerous in silico workflows and tools to profile sncRNA expression. Thus, we also discuss the key detection methods for cancer-relevant sncRNAs, including the discovery of genes that have yet to be described