13,815 research outputs found
Markov Chain Beam Randomization: a study of the impact of PLANCK beam measurement errors on cosmological parameter estimation
We introduce a new method to propagate uncertainties in the beam shapes used
to measure the cosmic microwave background to cosmological parameters
determined from those measurements. The method, which we call Markov Chain Beam
Randomization, MCBR, randomly samples from a set of templates or functions that
describe the beam uncertainties. The method is much faster than direct
numerical integration over systematic `nuisance' parameters, and is not
restricted to simple, idealized cases as is analytic marginalization. It does
not assume the data are normally distributed, and does not require Gaussian
priors on the specific systematic uncertainties. We show that MCBR properly
accounts for and provides the marginalized errors of the parameters. The method
can be generalized and used to propagate any systematic uncertainties for which
a set of templates is available. We apply the method to the Planck satellite,
and consider future experiments. Beam measurement errors should have a small
effect on cosmological parameters as long as the beam fitting is performed
after removal of 1/f noise.Comment: 17 pages, 23 figures, revised version with improved explanation of
the MCBR and overall wording. Accepted for publication in Astronomy and
Astrophysics (to appear in the Planck pre-launch special issue
Hydrophobic, Organically-Modified Silica Gels Enhance the Structure of Encapsulated Apomyoglobin
Insertion of hydrophobic groups in a silica matrix, by addition of propyl- or trifluoropropyltrimethoxysilane, leads to a surprising increase in the helical content of apomyoglobin following encapsulation by the sol–gel techniqu
Gravastars and Black Holes of Anisotropic Dark Energy
Dynamical models of prototype gravastars made of anisotropic dark energy are
constructed, in which an infinitely thin spherical shell of a perfect fluid
with the equation of state divides the whole spacetime
into two regions, the internal region filled with a dark energy fluid, and the
external Schwarzschild region. The models represent "bounded excursion" stable
gravastars, where the thin shell is oscillating between two finite radii, while
in other cases they collapse until the formation of black holes. Here we show,
for the first time in the literature, a model of gravastar and formation of
black hole with both interior and thin shell constituted exclusively of dark
energy. Besides, the sign of the parameter of anisotropy () seems to
be relevant to the gravastar formation. The formation is favored when the
tangential pressure is greater than the radial pressure, at least in the
neighborhood of the isotropic case ().Comment: 16 pages, 8 figures. Accepted for publication in Gen. Rel. Gra
Specifying and Verifying Concurrent Algorithms with Histories and Subjectivity
We present a lightweight approach to Hoare-style specifications for
fine-grained concurrency, based on a notion of time-stamped histories that
abstractly capture atomic changes in the program state. Our key observation is
that histories form a partial commutative monoid, a structure fundamental for
representation of concurrent resources. This insight provides us with a
unifying mechanism that allows us to treat histories just like heaps in
separation logic. For example, both are subject to the same assertion logic and
inference rules (e.g., the frame rule). Moreover, the notion of ownership
transfer, which usually applies to heaps, has an equivalent in histories. It
can be used to formally represent helping---an important design pattern for
concurrent algorithms whereby one thread can execute code on behalf of another.
Specifications in terms of histories naturally abstract granularity, in the
sense that sophisticated fine-grained algorithms can be given the same
specifications as their simplified coarse-grained counterparts, making them
equally convenient for client-side reasoning. We illustrate our approach on a
number of examples and validate all of them in Coq.Comment: 17 page
Non-collinear coupling between magnetic adatoms in carbon nanotubes
The long range character of the exchange coupling between localized magnetic
moments indirectly mediated by the conduction electrons of metallic hosts often
plays a significant role in determining the magnetic order of low-dimensional
structures. In addition to this indirect coupling, here we show that the direct
exchange interaction that arises when the moments are not too far apart may
induce a non-collinear magnetic order that cannot be characterized by a
Heisenberg-like interaction between the magnetic moments. We argue that this
effect can be manipulated to control the magnetization alignment of magnetic
dimers adsorbed to the walls of carbon nanotubes.Comment: 13 pages, 5 figures, submitted to PR
Von Bertalanffy's dynamics under a polynomial correction: Allee effect and big bang bifurcation
In this work we consider new one-dimensional populational discrete dynamical systems in which the growth of the population is described by a family of von Bertalanffy's functions, as a dynamical approach to von Bertalanffy's growth equation. The purpose of introducing Allee effect in those models is satisfied under a correction factor of polynomial type. We study classes of von Bertalanffy's functions with different types of Allee effect: strong and weak Allee's functions. Dependent on the variation of four parameters, von Bertalanffy's functions also includes another class of important functions: functions with no Allee effect. The complex bifurcation structures of these von Bertalanffy's functions is investigated in detail. We verified that this family of functions has particular bifurcation structures: the big bang bifurcation of the so-called "box-within-a-box" type. The big bang bifurcation is associated to the asymptotic weight or carrying capacity. This work is a contribution to the study of the big bang bifurcation analysis for continuous maps and their relationship with explosion birth and extinction phenomena.info:eu-repo/semantics/publishedVersio
HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection.
Antiviral innate host defenses against acute viral infections include suppression of host protein synthesis to restrict viral protein production. Less is known about mechanisms by which viral pathogens subvert host antiviral innate responses for establishing their replication and dissemination. We investigated early innate defense against human immunodeficiency virus (HIV) infection and viral evasion by utilizing human CD4+ T cell cultures in vitro and a simian immunodeficiency virus (SIV) model of AIDS in vivo Our data showed that early host innate defense against the viral infection involves GCN2-ATF4 signaling-mediated suppression of global protein synthesis, which is exploited by the virus for supporting its own replication during early viral infection and dissemination in the gut mucosa. Suppression of protein synthesis and induction of protein kinase GCN2-ATF4 signaling were detected in the gut during acute SIV infection. These changes diminished during chronic viral infection. HIV replication induced by serum deprivation in CD4+ T cells was linked to the induction of ATF4 that was recruited to the HIV long terminal repeat (LTR) to promote viral transcription. Experimental inhibition of GCN2-ATF4 signaling either by a specific inhibitor or by amino acid supplementation suppressed the induction of HIV expression. Enhancing ATF4 expression through selenium administration resulted in reactivation of latent HIV in vitro as well as ex vivo in the primary CD4+ T cells isolated from patients receiving suppressive antiretroviral therapy (ART). In summary, HIV/SIV exploits the early host antiviral response through GCN2-ATF4 signaling by utilizing ATF4 for activating the viral LTR transcription to establish initial viral replication and is a potential target for HIV prevention and therapy.IMPORTANCE Understanding how HIV overcomes host antiviral innate defense response in order to establish infection and dissemination is critical for developing prevention and treatment strategies. Most investigations focused on the viral pathogenic mechanisms leading to immune dysfunction following robust viral infection and dissemination. Less is known about mechanisms that enable HIV to establish its presence despite rapid onset of host antiviral innate response. Our novel findings provide insights into the viral strategy that hijacks the host innate response of the suppression of protein biosynthesis to restrict the virus production. The virus leverages transcription factor ATF4 expression during the GCN2-ATF4 signaling response and utilizes it to activate viral transcription through the LTR to support viral transcription and production in both HIV and SIV infections. This unique viral strategy is exploiting the innate response and is distinct from the mechanisms of immune dysfunction after the critical mass of viral loads is generated
Challenges to evaluation of multilingual geographic information retrieval in GeoCLEF
This is the third year of the evaluation of
geographic information retrieval (GeoCLEF)
within the Cross-Language Evaluation Forum
(CLEF). GeoCLEF 2006 presented topics and
documents in four languages (English,
German, Portuguese and Spanish). After two
years of evaluation we are beginning to
understand the challenges to both Geographic
Information Retrieval from text and of
evaluation of the results of geographic
information retrieval. This poster enumerates
some of these challenges to evaluation and
comments on the limitations encountered in the
first two evaluations
Small-Angle CMB Temperature Anisotropies Induced by Cosmic Strings
We use Nambu-Goto numerical simulations to compute the cosmic microwave
background (CMB) temperature anisotropies induced at arcminute angular scales
by a network of cosmic strings in a Friedmann-Lemaitre-Robertson-Walker (FLRW)
expanding universe. We generate 84 statistically independent maps on a 7.2
degree field of view, which we use to derive basic statistical estimators such
as the one-point distribution and two-point correlation functions. At high
multipoles, the mean angular power spectrum of string-induced CMB temperature
anisotropies can be described by a power law slowly decaying as \ell^{-p}, with
p=0.889 (+0.001,-0.090) (including only systematic errors). Such a behavior
suggests that a nonvanishing string contribution to the overall CMB
anisotropies may become the dominant source of fluctuations at small angular
scales. We therefore discuss how well the temperature gradient magnitude
operator can trace strings in the context of a typical arcminute
diffraction-limited experiment. Including both the thermal and nonlinear
kinetic Sunyaev-Zel'dovich effects, the Ostriker-Vishniac effect, and the
currently favored adiabatic primary anisotropies, we find that, on such a map,
strings should be ``eye visible,'' with at least of order ten distinctive
string features observable on a 7.2 degree gradient map, for tensions U down to
GU \simeq 2 x 10^{-7} (in Planck units). This suggests that, with upcoming
experiments such as the Atacama Cosmology Telescope (ACT), optimal
non-Gaussian, string-devoted statistical estimators applied to small-angle CMB
temperature or gradient maps may put stringent constraints on a possible cosmic
string contribution to the CMB anisotropies.Comment: 17 pages, 9 figures. v2: matches published version, minor
clarifications added, typo in Eq. (8) fixed, results unchange
Internal kinematics of spiral galaxies in distant clusters III. Velocity fields from FORS2/MXU spectroscopy
(Abridged) We study the impact of cluster environment on the evolution of
spiral galaxies by examining their structure and kinematics. Rather than
two-dimensional rotation curves, we observe complete velocity fields by placing
three adjacent and parallel FORS2 MXU slits on each object, yielding several
emission and absorption lines. The gas velocity fields are reconstructed and
decomposed into circular rotation and irregular motions using kinemetry. To
quantify irregularities in the gas kinematics, we define three parameters:
sigma_{PA} (standard deviation of the kinematic position angle), Delta phi (the
average misalignment between kinematic and photometric position angles) and
k_{3,5} (squared sum of the higher order Fourier terms). Using local,
undistorted galaxies from SINGS, these can be used to establish the regularity
of the gas velocity fields. Here we present the analysis of 22 distant galaxies
in the MS0451.6-0305 field with 11 members at z=0.54. In this sample we find
both field (4 out of 8) and cluster (3 out of 4) galaxies with velocity fields
that are both irregular and asymmetric. We show that these fractions are
underestimates of the actual number of galaxies with irregular velocity fields.
The values of the (ir)regularity parameters for cluster galaxies are not very
different from those of the field galaxies, implying that there are isolated
field galaxies that are as distorted as the cluster members. None of the
deviations in our small sample correlate with photometric/structural properties
like luminosity or disk scale length in a significant way.
Our 3D-spectroscopic method successfully maps the velocity field of distant
galaxies, enabling the importance and efficiency of cluster specific
interactions to be assessed quantitatively.Comment: accepted for publication in A&A, high resolution version available at
http://www.astro.rug.nl/~kutdemir/papers
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